Sidi Chen

@sidichen

Gene editing. Technology. Cancer. Immunology. Cell and gene therapy. Antibody. mRNA vaccine. @ Yale Genetics & Systems Biology. ## CRISPR in vivo ##

New Haven, CT

Joined December 2010

246Following

1KFollowers

Sidi Chen@sidichen · Jul 18

Proud to present our work at #KCRS25 on CAR-T screens, cell therapy and kidney cancer from @YaleMed @YaleGenetics @YaleWestCampus @YaleCancer Honored to be in session with Drs. Chuck Drake at JnJ, Nadal Rios at Hutch & Patrick Ott at Farber, hosted by David Braun &Hans Hammers.

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Sidi Chen Retweeted

KidneyCAN@kidneycan · Jul 18

#KCRS25 Session 6 highlighted how researchers are pushing the boundaries of what immunotherapy can do for kidney cancer patients. Engaging Native Immunity with ENPP3 with Chuck Drake TCR-Engineered Cell Therapy with @RosaNadalrios Next Generation T-Cell Engineering with…

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Sidi Chen Retweeted

Cancer Research Institute@CancerResearch · Jul 17

🎉 CRI is proud to announce the 2025 CLIP and Technology Impact Award projects, a new class of high‑potential studies and tools designed to push cancer immunotherapy further and faster! Explore: bit.ly/4lzfuZi #Immunotherapy #CancerResearch #CancerResearcher

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Sidi Chen@sidichen · Jun 17

Organizing an AI symposium on 6/20 with SAPA-CT at Yale. Please check it out and all are welcome to register/attend! @YaleWestCampus

sidichen's tweet image. Organizing an AI symposium on 6/20 with SAPA-CT at Yale. Please check it out and all are welcome to register/attend! @YaleWestCampus

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Sidi Chen@sidichen · May 15

Excited to present our new work on multiplex immune gene therapies for cancer @ASGCT 2025 @NOLA @YaleMed @YaleCancer @YaleGenetics @YaleWestCampus

sidichen's tweet image. Excited to present our new work on multiplex immune gene therapies for cancer @ASGCT 2025 @NOLA @YaleMed @YaleCancer @YaleGenetics @YaleWestCampus

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Sidi Chen Retweeted

Yale Cancer Center@YaleCancer · Apr 29

.@sidichen co-chairs a symposium highlighting the transformative field of adoptive cell therapies for #cancer treatment #AACR25 with Dr. Daniel Powell @PennMedicine @AACR @SmilowCancer @YaleWestCampus @YaleGenetics

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Sidi Chen@sidichen · Mar 20

Our lab generated 4 new lines of Cas12a transgenic mice and demonstrated utility in immune engineering, tumor modeling, and genetic disease treatment. Around to share w the field & community! @YaleMed @YaleWest @YaleGenetics @YaleData Also @LabWinslow nature.com/articles/s4155…

sidichen's tweet card. Nature Biomedical Engineering - Knock-in mice conditionally or constitutively expressing Cas12 variants enable a wide range of ex vivo and in vivo applications requiring multiplexed genome...

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Sidi Chen@sidichen · Jan 16

Our new “MUCIG” therapy @FF Zhang ⁦@ScienceChow⁩ @GW ⁩ ⁦@YaleCancer⁩ ⁦@YaleGenetics⁩ ⁦@YaleWestCampus⁩ Multiplexed inhibition of immunosuppressive genes with Cas13d for combinatorial cancer immunotherapy | Nature Biotechnology nature.com/articles/s4158…

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Sidi Chen@sidichen · Jan 16

Our team’s new work “MUCIG” cancer therapy - Multi-target approach counters tumor growth in several cancers | Yale News @Feifei Zhang ⁦@ScienceChow⁩ @Guangchuan Wang ⁦@Yale⁩ ⁦@YaleCancer⁩ ⁦@YaleGenetics⁩ ⁦@YaleWestCampus⁩ news.yale.edu/2025/01/16/mul…

sidichen's tweet card. Yale scientists have developed a treatment approach that simultaneously targets multiple immune-suppressing genes and inhibits growth in four types of cancer.

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Sidi Chen@sidichen · Jul 10, 2024

Honored to serve on the panel of #AI for drug discovery in biomedicine at #AIME 2024 Utah. Very stimulating discussions on future of medicine, challenges etc, with experts and audience. @YaleData @yaledatascience @YaleGenetics @YaleCancer @Yale_Ventures

sidichen's tweet image. Honored to serve on the panel of #AI for drug discovery in biomedicine at #AIME 2024 Utah. Very stimulating discussions on future of medicine, challenges etc, with experts and audience. @YaleData @yaledatascience @YaleGenetics @YaleCancer @Yale_Ventures

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Sidi Chen@sidichen · Jun 25, 2024

Our first in vivo primary NK screen that discovered new NK cellular checkpoints. Kudos for team for their 5 years of work. nature.com/articles/s4158… @YaleGenetics @YaleMed @YaleWestCampus @YaleCancer @YaleData

sidichen's tweet card. Nature Biotechnology - The antitumor efficacy of chimeric antigen receptor natural killer cells is enhanced by genetic engineering.

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Sidi Chen Retweeted

MIT Jameel Clinic for AI & Health@AIHealthMIT · Jun 24, 2024

“Building a community and paying attention to that community is the essence of getting things done.” Today #JameelClinic Advisory Board Chair and Nobel laureate Phil Sharp celebrated the 50th anniversary of his lab, “The Sharpies” — half a century of sharp minds!

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Sidi Chen@sidichen · Mar 17, 2024

Our new high fidelity enhanced AsCas12a/Cpf1 transgenic mice after five years of work. Generated by Matt Dong and colleagues here in lab at @YaleGenetics @YaleCancer @YaleMed @YaleWestCampus Anyone who want to try them out feel free to please contact us. biorxiv.org/content/10.110…

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Sidi Chen@sidichen · Mar 14, 2024

Congrats for Ariel Xiaoyu Zhou my postdoc in @YaleCancer @YaleGenetics @YaleMed @YaleWestCampus @YaleData getting an NIH/NCI K99/R00 award starting this month to study T cells and engineer next generation CAR-T cell therapy for cancer!

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Sidi Chen@sidichen · Sep 15, 2023

🤩🤩 Beautiful cover art @NatureBiotech depicting new paper led by Xiaoyun Dai @sidichen lab 👇🏽👇🏿👇

NNature Biotechnology@NatureBiotech · Sep 13, 2023

The September issue is live nature.com/nbt/volumes/41… On the cover, Dai et al. screen a large pool of differentially mutated CAR-T cells for genetic perturbations that enhance function go.nature.com/3WPqyEM

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Sidi Chen Retweeted

Frontiers in Genome Editing@FrontGenEditing · Sep 25, 2023

We are thrilled to announce the official launch of Genome Editing in Cancer and Immunology, a specialty section journal led by Prof. @sidichen of @YaleMed. Ready to receive your submissions. Discover more here: fro.ntiers.in/GECancerandImm…

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Sidi Chen@sidichen · Jul 27, 2023

Our work at Nature Immunology on a new way of cell therapy engineering. Proud of 1st author Ariel & team. Special Tx to Dr. Levchenko. @Yale @YaleGenetics @YaleCancer @YaleWestCampus @YaleData @YaleMed nature.com/articles/s4159…

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Sidi Chen Retweeted

Yale West Campus@YaleWestCampus · Jul 10, 2023

Scientists at Yale's Systems Biology Institute have developed a ‘MAJESTIC’ gene delivery and immune cell engineering technology with the potential to advance cell therapies for cancer and other diseases bit.ly/Chen-majestic @sidichen @yale @YaleMed @natBME

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