Sebastian López
@mdsebaslopez
Autoimmune Neurology | Neuroimmunology | Neurohospitalist at @Mayoclinic | Personal account
Happy to share Syc-Mazurek et al study of attack & remission MRI in #MOGAD vs #MS ➡️ Resolution of 1 lesion predicts #MOGAD and disappearance of ≥2 lesions separates #MOGAD completely from #MS ➡️ MRI 1 yr post #MOGAD brain/spine attack may aid diagnosis👇jnnp.bmj.com/content/early/…
Dear Neurology Residents Starting in the ED Next Month, You will frequently encounter “?GBS” or “GBS rule out” consults. Please remember to carry your reflex hammer, save this post for future reference, and read the open-access review that I share ⬇️. 🤓 Since you won’t have…
Delighted to share our new study, led by @annacgeraghty and @LehiAcosta , uncovering the cellular dysregulation underpinning cognitive impairment after CAR T cell therapy and a strategy to rescue this cellular and cognitive dysfunction in mice. 1/ cell.com/cell/fulltext/…
Delighted to share Cacciaguerra et al study ➡️ MRI guidelines in MS recommend 2 sagittal-T2 spine images but axial is optional ➡️ Here, axial-T2 found 2x more lesions vs sagittal ➡️ Thus, future guidelines should recommend both sagittal & axial images👇 link.springer.com/article/10.100…
Thanks for sharing our work on ‘CNS Tractopathies’ so nicely. This is often clinically challenging, given the broad differential diagnosis. We hope this article helps neurologists and neuroradiologists narrow down the diagnosis!
1/Do you have trouble keeping track of all the tractopathies? Wish you knew mo’ about mo’ tor neuron diseases? Read on for what you need to know in this months Radiographics review of motor neuron diseases! doi.org/10.1148/rg.240… @cookyscan1 @RadG_editor @RadioGraphics
1/Do you have trouble keeping track of all the tractopathies? Wish you knew mo’ about mo’ tor neuron diseases? Read on for what you need to know in this months Radiographics review of motor neuron diseases! doi.org/10.1148/rg.240… @cookyscan1 @RadG_editor @RadioGraphics
Happy to share @albertaboseif et al multicenter study showing 4% of #MOGAD with meningitis ➡️ Frequent misdiagnosis as infection ➡️ Updates in criteria could incorporate this phenotype ➡️ Path had meningeal T & B cells, microglia & cortical myelin loss👇 jamanetwork.com/journals/jaman…
Great time celebrating Dr. Newman — our exceptional fellow in Autoimmune Neurology!
MRI findings of genetic diseases often misdiagnosed as MS. A-D LHON B CADASIL. D CANVAS. E Krabbe disease F Cobalamin C disease. G polymerase gamma gene disease. H Alexander J/K CADASIL L Spastic paraplegia 5 with diffuse leukoencephalopathy pubmed.ncbi.nlm.nih.gov/40446704/
A 64-year-old woman presented with 18 months of progressive scalp-neck dysesthesias, left leg weakness, and urinary urgency. Read more: hubs.la/Q03hKGRg0 #NeuroTwitter #NeuroX
Thrilled to share our recent study, which highlights the risk of false AChR-IgG positivity by RIPA in clinical practice 🎯 @PaolaChessa4 @EliaSechi @damato_v 👏🏻 neurology.org/doi/10.1212/WN…
#CASPR2-#antibody diseases are provide clues to mechanisms of autoantigen-specific tolerance Here - in @ScienceAdvances - we show how central and peripheral B cell tolerance licences pathogenic CASPR2 antibody generation. science.org/doi/10.1126/sc… More below 👇🏿
In 3 months (and zero days), we have the inaugural @MayoClinic #florida #autoimmune #neurology meeting. 1.5 days of great speakers and 0.5 days to spend on the beautiful Jacksonville beach 🏖️ Please sign up now ✍️ ce.mayo.edu/neurology-and-… @MayoClinicNeuro @DoctorQMd
neurology.org/doi/10.1212/NX… Proud to share @StefanoMascio91 latest work on PLP1 antibodies in demyelinating diseases. PLP1 abs are mainly found in patients with non MS diseases with combined central and peripheral demyelination, but also in rare seronegative NMOSD
Our new CASPR2 paper is out @ANA_journals 🤩 Headlines: Patients have neuropathic pain & fatigue as their main long term complaints which determine QoL. 😰 These are NOT immunotherapy responsive. 👩🏾⚕️💊 We also report other nuggets in this thread 🧵 ⬇️ onlinelibrary.wiley.com/doi/10.1002/an…
Had a great time on the @GreenJournal Neurology Podcast chatting about CSF correction factors for traumatic LP in adults! Hopefully a valuable discussion for those using these "rules of thumb" (e.g. subtract 1 WBC for every 1000 RBC) in clinical practice: youtube.com/watch?v=lihZod…
Delighted to share @Lauz_Caccia et al #MOGAD epidemiology study: ➡️ 1st such population-based study in North America ➡️ Prevalence of 3.7/100K in Olmsted County & 2.61/100K in Martinique ➡️Trend towards increased incidence & recognition over time 👇 link.springer.com/article/10.100…
Why Choose Mayo Clinic for #MOGAD Care youtube.com/watch?v=WIkbBv… @EoinFlanagan14 @Mayo_AING @mdsebaslopez @chenmayo @MayoClinicNeuro
Delighted to share @dinoto_ale et al study on the rare cerebellar attacks in #NMOSD attacks: ➡️ Often coexist with brainstem attacks ➡️ MRIs with peduncle or dentate nucleus lesions ➡️ Should be incorporated in upcoming 2025 #NMOSD diagnostic criteria 👇 neurology.org/doi/10.1212/NX…
Quick reminder Fantastic #autoimmune #neurology course in Florida ☀️🏖️👨⚕️ 👩🏾⚕️ Come and enjoy sun, beach and great speakers….a stellar line up! ce.mayo.edu/neurology-and-… @MayoClinicNeuro @MayoFL_NeuroRes @MayoClinic @DoctorQMd @mdsebaslopez @Div_Dubey @EoinFlanagan14 @GDay_Neuro