Mayo Florida AutoImmune Neurology Group
@Mayo_AING
Prof Sarosh Irani (Mayo Clinic, Florida & ex-Oxford: Antibodies, B & T cells in Neurology: towards treatments & causes. #encephalitis #NMO #antibody #neurology
Thanks for highlighting this work. The patients we are seeing continue to teach us so much!
🔱The reversed trident sign, with ventral spinal cord enhancement, mirrors the classic trident sign seen in neurosarcoidosis but with an atypical distribution. Unlike MS or NMOSD, which lack this pattern, it pointed toward spinal cord sarcoidosis. doi.org/10.1212/WNL.00…
At least it recognised your expertise!
Got head-hunted today by email. This is when I know that AI might have to get a little more sophisticated, or else someone is trying to tell me something important
Big welcome from your recently immigrated neighbours! Looking forward to welcoming you and the team
Big changes, new! After an incredible journey @UCSFmac, we’ve officially moved to @MayoClinic in Jacksonville, FL. The renovated lab is ready, and we’re excited to inaugurate it this Monday. Grateful to this amazing team—onward! @gowoon_son @MayoPathology
🇨🇦 Happy #CanadaDay! S/O to TSF Canada Ambassadors who have been illuminating #NMOSD, #MOGAD, #AE and other rare neuroimmune disorders. To get in touch with a member of TSF Canada, please email [email protected]
So thrilled that I successful passed my DPhil viva “Encephalitis in Vietnamese Children” at University of Oxford! Deep gratitude to be supervised by @Le_Van_Tan, @Mayo_AING, @hugocturner, @drleighannjones, @OUCRU_Programme!
Great meeting - thank you to the organisers, all the speakers and students who presented such cool data
Heading back from the SYNABS & Generate Symposium - beautiful venue, friendly atmosphere. Big thanks to the organizers Christian Geis, Frank Leypoldt, and their teams for making it such a wonderful event. #autoimmunity
Great study 🥳 Clinical practice has convinced me that this remains an under-recognised phenotype. And you pull in lymphocytes! Who can ask for more!! @albertaboseif @EoinFlanagan14 @mayoneurores @MayoClinic @TheSumairaFDN @MayoClinicNeuro
Happy to share @albertaboseif et al multicenter study showing 4% of #MOGAD with meningitis ➡️ Frequent misdiagnosis as infection ➡️ Updates in criteria could incorporate this phenotype ➡️ Path had meningeal T & B cells, microglia & cortical myelin loss👇 jamanetwork.com/journals/jaman…
Also,🚨 kidney dysfunction (eGFR <45 mL/min/1.73 m2) was associated with higher p-tau217 (i.e., false positive results). To ensure accurate interpretation, we recommend measuring creatinine (and eGFR) together with p-tau217.
Heard it before??? It’s not stridor but an inspiratory noise which myself and @dubeydiv observed in patients with #iglon5 #antibodies
Stridor is a common and presenting feature of IgLON5-antibody disease. This Research Letter describes an additional inspiratory noise distinct from stridor, in three patients, observed independently across two centers. ja.ma/3HkZD1y
My Editorial is out on actively immunised mouse model in NMDAR. Hope you enjoy! academic.oup.com/brain/article/…
Beware commercial tissue based assays (TBAs) to detect cell surface autoantibodies in neurology. TBAs are often used as screening tests and are reader dependent. Bottom line: please think clinically when diagnosing autoimmune neurological syndromes pubmed.ncbi.nlm.nih.gov/40393020/
Thank you for sharing such an insightful case. We're all learning thanks to your work.
This is very useful. Question is how we now improve the models? Ideas?
It's not the models, it's the data! We show that a substantial proportion of a widely used TCR-pMHC database does not functionally validate, causing underestimation of performance of TCR-pMHC prediction models.🧵 biorxiv.org/content/10.110…
Read more 👇 ndcn.ox.ac.uk/news/oxford-le…
The inaugural #Mayo #clinic Autoimmune Neurology conference @MayoClinicNeuro @MayoClinic Dr Gregory Day speaking about trials and treatments in #autoimmune #encephalitis
Many congratulations to Professor Irani and all co-authors for winning the prestigious 2024 PNAS Cozzarelli Prize in Biomedical Science. 👏🧠 The winning paper was a collaboration between NDCN, The Department of Statistics, and the Mayo Clinic in Florida.