Luis G. Palma (@luigalpal.bsky.social)

Thanks everyone involved in the work (@GayathriKartha, Arnau, Jessica, Patricia). Special thanks also to our amazing team of collaborators: @mercedesbarrero @PayerLab @Menendez_Lab It’s been a pleasure to work with you all!!

Thrilled to share with you the latest work from my PhD in @BigSpinLab @HMar_research @CarrerasIJC published in @BloodPortfolio We’ve programmed blood stem cells from PSCs using CRISPRa screen and found a new “bloody” cocktail #CRISPR #HSCs #StemCells kwnsfk27.r.eu-west-1.awstrack.me/L0/https:%2F%2…

Very happy to have our latest work on how IκBα regulates stemness independently from NF-κB. It has been a terrific collaborative work led by Lluís Espinosa (@BigSpinLab) and Daniel Alvarez-Villanueva (@Dani_AlvVill) @HMar_research #nfkb #ikb #inflammation #stemcells

How stem cells respond to infection, inflammation and ageing bit.ly/4lINKS2

Optical pooled screening is enhanced by amplification of barcodes before in situ sequencing go.nature.com/3ZVzqOi rdcu.be/exfh0

Proteomic aging signatures across mouse organs and life stages embopress.org/doi/full/10.10…

We’re @BlaineyLab sharing a major update to CROPseq-multi, our versatile system for CRISPR screens that is compatible with individual and combinatorial perturbations, diverse SpCas9-based technologies, and multiple high-content, single-cell readouts. biorxiv.org/content/10.110…

A method for synthesis and assembly of megabase-scale DNA, along with an approach to deliver it into mouse embryos, offers a valuable tool for investigating de novo epigenetic regulation. nature.com/articles/s4159…

DiffMethylTools: a toolbox of the detection, annotation and visualization of differential DNA methylation biorxiv.org/content/10.110… the github link is dead, though..

Happy to share our recent review as part of the @CellStemCell Hallmarks series, co-authored with friends/colleagues/collaborators, Anne Brunet (@BrunetLab) and Peggy Goodell (@Goodell_lab) Hallmarks of stem cell aging: Cell Stem Cell cell.com/cell-stem-cell…

The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states dlvr.it/TLCFdR

Online Now: The RNA-stability-independent role of the RNA m6A reader YTHDF2 in promoting protein translation to confer tumor chemotherapy resistance dlvr.it/TLBW76

A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions nature.com/articles/s4358…

Programmable RNA acetylation with CRISPR–Cas13 nature.com/articles/s4158…

An atlas of TF driven gene programs across human cells biorxiv.org/content/10.110…

Metabolic engineering is a powerful tool to reprogramme cells to produce value-added chemicals. This article discusses autonomous dynamic regulation, that is, responses triggered directly by a stimulus, and its application to metabolic engineering: bit.ly/4kDPYS2

"Programmable gene insertion in human cells with a laboratory-evolved CRISPR-associated transposase" Witte IP, Lampe GD, Eitzinger S [..] Sternberg SH, Liu DR. Science. 2025-05-15. science.org/doi/10.1126/sc…

.@HMar_research Un paso más cerca de la producción fiable de células madre sanguíneas para la medicina regenerativa biotech-spain.com/es/articles/un…

Happy that @Biotech_Spain share my PhD work!!

Precision epigenetic editing: Technological advances, enduring challenges, and therapeutic applications. A review by @stanleyqilab @Stanford_ChEMH @bioe_stanford @Stanford in @CellChemicalBiology #ASGCT2025 hubs.li/Q03mxm5f0