Luca Pinello
@lucapinello
Computational methods for epigenetic, CRISPR genome editing and single-cell genomics. Associate Professor at MGH / Harvard Medical School. http://pinellolab.org
🎄 What’s the best gift under the tree for a computational biologist? 🎁 A new assay that refines our view of gene regulation: ACCESS-ATAC! #Genomics #SingleCell
(1/8) Excited to share our latest preprint introducing ACCESS-ATAC, a high-resolution approach to measure chromatin accessibility and transcription factor binding: biorxiv.org/content/10.110…
I am starting a computational lab at LIOS, Riga, Latvia, and going to recruit a few people. Please DM if you are interested in a postdoc or PhD position in my Metabolic Research Group. I can highly recommend Riga, it is a beautiful city with very good living conditions.
I'm excited to share work on a research direction my team has been advancing: connecting machine learning derived genetic variant embeddings to downstream tasks in human genetics. This work was led by the amazing @divyanshi91! biorxiv.org/content/10.110…
Excited to be at #ISMBECCB2025! I'll be presenting at RegSys on "Learning the Regulatory Genome by Destruction and Creation" (Thursday 3:15PM in Room 11BC). I'm looking forward to connecting with both new and old friends throughout the conference! 🧬 #CRISPR #Genomics #Diffusion
Great to see it finally out —such a fantastic collaboration with @BKleinstiver, @RachelSilvers11 and team!
In @nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-Cas9 enzymes, offering safer & more genome editing tools. 🧬🖥️ @RachelSilvers11 @CGM_MGH @MGH_RI @MassGeneralNews @harvardmed nature.com/articles/s4158…
In @nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-Cas9 enzymes, offering safer & more genome editing tools. 🧬🖥️ @RachelSilvers11 @CGM_MGH @MGH_RI @MassGeneralNews @harvardmed nature.com/articles/s4158…
🚨📰TWEETORIAL time📰🚨 Excited to share recent work from our lab on noncoding genomics 🔎🧬: High-resolution CRISPR mutagenesis of the MYC TAD (~3 Mb) in 6 different human cancer cell lines nature.com/articles/s4146…
We are thrilled to join the FutureHouse community, @SGRodriques @FutureHouseSF! We are seeking exceptional machine learning experts to help create predictive virtual 3D mammalian embryos and virtual scientists for advancing human health. As part of the FutureHouse community, we…
The info session for our FutureHouse fellowship is TOMORROW, Tuesday, 9:00am Pacific time. Come get all your questions answered! Details are on our website (see link below). Now for an AI generated image that we present as an offering to the Algorithms, may they Boost our Post.
Excited to be visiting @DukeU to share insights on computational methods for single-cell genomics and CRISPR genome editing! Thank you for hosting me @Wings7Spread! 🙏
Happening this week with special guest @lucapinello! Check out dmpi.duke.edu/duke-single-ce… for more information. We hope to see you all there 🧬
Amazing new assay that allows testing of multiple DNA sequences, similar to MPRA, but in an endogenous setting. Incredible potential! Congrats @JKribelbauer , @BartDeplancke and the entire team – grateful and lucky to be an early adopter. Check it out!
Finally out! We present EXTRA-seq, a new EXTended Reporter Assay to quantify endogenous enhancer-promoter communication at kb scale! biorxiv.org/content/10.110… A 🧵about what it can do: