Sherwood Lab
@SherwoodLab
We develop technologies @harvardmed that combine #stem_cell biology, #CRISPR_Cas9 genome editing screens, and #computational_biology to understand gene function
(1/8) Excited to share our latest preprint introducing ACCESS-ATAC, a high-resolution approach to measure chromatin accessibility and transcription factor binding: biorxiv.org/content/10.110…
We are very happy to see that our manuscript, 'Joint Genotypic and Phenotypic Outcome Modeling Improves Base Editing Variant Effect Quantification,' is now published in @NatureGenet . Congratulations @JayoungR
Absolutely thrilled to share this incredible work led by @JayoungR ! A huge shoutout to the collaborative efforts with @SherwoodLab, @ccassa, their teams and several key collaborators. Check out her excellent twettorial for a summary and link to the preprint!#CRISPR #BEAN 🧬🌟☕️
Absolutely thrilled to share this incredible work led by @JayoungR ! A huge shoutout to the collaborative efforts with @SherwoodLab, @ccassa, their teams and several key collaborators. Check out her excellent twettorial for a summary and link to the preprint!#CRISPR #BEAN 🧬🌟☕️
Excited to share our work introducing BEAN🫘, a pipeline that greatly improves the power of CRISPR base editing screens🚀! BEAN utilizes surrogate per-gRNA editing outcomes, identifying coding & noncoding variants impacting LDL cholesterol uptake. 📰medrxiv.org/content/10.110… (1/)
‼️⚠️Registration Deadline TODAY!⚠️‼️ Register now for the 'From Genetic Discoveries to Gene Function in Human Diseases' Conference to secure your slot and join us in Portugal from 13 - 16 July 2024 #GWAS24☀️🏌️ 🔗➡️bit.ly/4bnHuu6
Excited to share our work introducing BEAN🫘, a pipeline that greatly improves the power of CRISPR base editing screens🚀! BEAN utilizes surrogate per-gRNA editing outcomes, identifying coding & noncoding variants impacting LDL cholesterol uptake. 📰medrxiv.org/content/10.110… (1/)
I’m excited to share REGatta, a project by @James_D_Fife from @CassaLabBWH which uses biobank data to estimate the clinical risk of rare variants within regions of established disease genes – Open access link @AJHGNews authors.elsevier.com/a/1h8Og_4GsWeU0 🧵