Longhua Guo
@longhua_guo
genetics | genomics | aging, regeneration and rejuvenation. Assistant Professor @ U of Michigan.
The summary: Aging, regeneration and whole-body rejuvenation in long-lived planarians nature.com/articles/s4358…
New publication from the lab @pnas . With the collaboration of Dr. Ping Kang @pingkang0, we uncovered how developmental NF-kB signaling links developmental timing (time to maturity) to lifespan😊😊pnas.org/doi/10.1073/pn…
Excited to share our new study in Cell—congrats to Daniel, co-authors, and our collaborators in the @PeterLyLab What began as pure curiosity led to a tool for modulating mitochondrial abundance in vitro and in vivo. A new direction for the Wu lab begins! cell.com/cell/fulltext/…
Join #CPOD, @TheSpenceLab & @longhua_guo tomorrow 5/20 at 4pm in Buhl 5915 for @KTsonis seminar! #GoBlueMed #UmichMedScience
Golden retriever picks up cat for family photo
C. elegans transgenerational avoidance of P. fluorescens is mediated by the Pfs1 sRNA and vab-1 | Science Advances science.org/doi/10.1126/sc…
Chambers et al. w/@CoryDungan @Boehringer @prof_horvath @ClockFoundation @UKYCMB @UofA_ESRC @UARKHHPR @uacoehp @UArkResearch in @AgingCell Exploring epigenetic aging, senescence, and regeneration in skeletal muscle #myotwitter onlinelibrary.wiley.com/doi/full/10.11…
Research from fellow Xiaoting Dai and the @longhua_guo lab in @UMPhysiology published in @NatureAging shows regeneration of lost tissues in older planarians led to reversal of these age-associated changes in tissues both proximal and distal to the injury. nature.com/articles/s4358…
Planarian worms can regenerate into a more youthful version of themselves, finds a new U-M study. Figuring out the secrets of their immortality could lead to insights about aging for mammals, including people michmed.org/AQYNm
Our work is now online at Nature Aging (nature.com/articles/s4358…), with exciting updates: comparison with mice/human aging; expanded number of samples for single cell analysis; molecular and cellular signatures of aging and rejuvenation; assay/discussion on global rejuvenation.
Our recent preprint addresses the challenges in studying aging in an "immortal" species, and found that the sexual planarians do get old. However, they have a way to reverse age, which is related to their whole body regenerative capacity. biorxiv.org/content/10.110…
Planarian worms do not lose adult stem cells with age and can regenerate into a more youthful version of themselves, according to a new study by Xiaoting Dai, @longhua_guo @UMich & Vadim N. Gladyshev @gladyshev_lab et al. #aging doi.org/10.1038/s43587…
Online now! Dai et al. report age-associated physiological and molecular changes in the sexual lineage of S. mediterranea, and global reversal of such changes after regeneration. @longhua_guo @Xiaoting_Dai @LabNandakumar @AFARorg @pewhealth @UM_CPOD doi.org/10.1038/s43587…
There are good, bad, and ugly Professors. This is ugly.
I'm shocked to see racism happening in academia again, at the best AI conference @NeurIPSConf. Targeting specific ethnic groups to describe misconduct is inappropriate and unacceptable. @NeurIPSConf must take a stand. We call on Rosalind Picard @MIT @medialab to retract and…
Introducing 2024 AFAR Grants for Junior Faculty recipient @Yang_Lyu of @RutgersU who will research “Motivation Reward and Longevity as Influenced by Serotonin Dopamine and Metabolism.” Learn more here: afar.org/grantee-profil… #Longevity #Protein #Metabolism
Excited to share our work on live imaging of the entire course of body regeneration in the marine flatworm Macrostomum using transgenics & advanced microscopy. We hope these tools can unlock the unique biology of this fascinating intertidal animal. cell.com/cell-reports/f…
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@MDIBL @MDIBL_LMF is looking for support running their @mesoSPIM microscope ! Reach out to @PMurawala @MarkoPende for questions! mdibl.org/careers/micros…
@UM_CPOD congratulates CPOD Members Sundeep Kalantry & @longhua_guo on their prestigious NIH awards! Read more about their research & NIH awards written by Kelly Malcom of The University Record: record.umich.edu/articles/three… #GoBlueMed