Hua Bai
@TheBaiLab
Associate Professor at Iowa State University, Studying aging and autophagy, mitochondria, Peroxisome...
New publication from the lab @pnas . With the collaboration of Dr. Ping Kang @pingkang0, we uncovered how developmental NF-kB signaling links developmental timing (time to maturity) to lifespan😊😊pnas.org/doi/10.1073/pn…
Day 50 of #WhyScience 🤪🎇 Thrilled to share the preprint from one of my most talented trainees, Jon Levinsohn: "Single-Cell Spatial Mapping of Human Kidney Development Reveals the Critical Role of the Local Microenvironment in Cell Fate Decisions" Jon built a comprehensive…
Since there appears to be no surveillance mechanism to prevent translation of mRNAs with aberrant ends, understanding how defects in translation elongation arise, are recognized, and resolved is critical for developing an integrated view of mitochondrial protein synthesis quality…
Mitochondrial protein synthesis quality control | Human Molecular Genetics | Oxford Academic academic.oup.com/hmg/advance-ar…
Now online in @NDTsocial Multifactorial chronic kidney disease 🧐 Life is long and our kidneys have to take many hits, hence, adult CKD is usually multifactorial as is atherosclerosis or dementia. RF control is key and RF vary across world regions ▶️academic.oup.com/ndt/article-ab…
I’m thrilled to share a @biorxivpreprint for my postdoc work in the @PerrimonLab🎉. Together with our collaborators, we built a tissue-specific atlas of circulating secreted proteins in Drosophila 🧬🪰🧪🗺️. Thread below🧵 1/8 biorxiv.org/content/10.110…
Wow, fatty acid oxidation in neurons! Time to update the textbooks?!
A study in @NatMetabolism shows that under glucose-depleted conditions, neurons can use fatty acids as an alternative source of energy to support synaptic function. go.nature.com/46ArR2G
A new publication from the lab. We demonstrate that age-related decline of peroxisome biogenesis is conserved in human, especially in B cells. Thanks for the hard work of my student, Jacinta. And great collaboration with Marian Kohut. doi.org/10.1093/gerona…
Delighted to share our latest, expertly led by @KatlynGabriel_ and @ChoahK: FAF2 is a bifunctional regulator of peroxisomal homeostasis and saturated lipid responses Impactful work with therapeutic potential by our @GrekaLab team at @broadinstitute! science.org/doi/10.1126/sc…
The mitochondrial methylation potential gates mitoribosome assembly | Nature Communications nature.com/articles/s4146…
holy shit, it’s here! deepmind just released AlphaGenome. an AI model that reads 1 million bases of DNA and predicts how any mutation changes molecular function not just in single genes but across the entire regulatory genome. DNA is code, and you are software 1/
Transferrin receptor controls both autophagosome formation and closure via phosphatidylinositol 3-phosphate synthesis: Developmental Cell cell.com/developmental-…
IS AGING PROGRAMMED? I recently debated this with the brilliant @aubreydegrey, moderated by @realNathanCheng at Vitalist Bay in Berkeley. Check it out! Here is a humorous trailer; the full video is linked below.
🚀Super excited to share results from our joint study w/ @OcampoLab showing brain-specific partial reprogramming ameliorating cognitive decline. More evidence for the CNS potential of reprogramming, as we saw in Alzheimer's previously! (as did Altos Labs) prnewswire.com/news-releases/…
Online Now: Hepatic micropeptide modulates mitochondrial RNA processing machinery in hepatocellular carcinoma dlvr.it/TLKJXg
Endoplasmic reticulum–mitochondria contacts are prime hotspots of phospholipid peroxidation driving ferroptosis | Nature Cell Biology nature.com/articles/s4155…
You’re right, and the Church lab has also previously found a single factor (SRSF1) to induce cellular rejuvenation: biorxiv.org/content/10.110…
I love Shift's platform & am a happy investor, but finding a single factor isn't novel. @JanineSengstack's 2022 preprint biorxiv.org/content/10.110… identified 4 single rejuv TFs. What's cool in Shift's new result is 1. works in 2 cell types 2. it's a gene not just TF 3. more…
See post from Brian Calvi below. Flybase at IU is setting up a means to support Flybase efforts in the US.
We ask for everyone’s patience as we establish a parallel U.S. + other country fee system at Flybase IU
I agree with David in seeing ageing as a software problem, namely a software design flaw. However, I see ageing as a programmatic process that results not from the corruption of the software but rather from software programs that run-on. genomebiology.biomedcentral.com/articles/10.11…
We think of aging as a software problem—one that can be reinstalled
Introducing the world's first reasoning model in biology! 🧬 BioReason enables AI to reason about genomics like a biology expert. A thread 🧵: