Celeste Karch
@karchlab
Professor. Washington University School of Medicine. Genomics, stem cell models, molecular mechanisms of AD and other tauopathies. She/her. 🦋Karchlab
A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies: Stem Cell Reports cell.com/stem-cell-repo…
Online now! @RowanSaloner et al. used large-scale CSF proteomics to uncover molecular signatures in frontotemporal dementia, revealing RNA splicing and synaptic protein candidate markers for genetic and sporadic disease progression. @UCSFmac @allftd doi.org/10.1038/s43587…
Deliriously excited to share our new Neuron Perspective on transformative neuropathology—a roadmap to accelerate brain health discoveries through broader support of brain banks with tech-enabled, team-science approaches to tissue. 🧠 Perspective article: cell.com/neuron/fulltex……
A new study from the lab @NatureMedicine Over 6,000 proteins, more than 10,500 individuals. #Alzheimers, #Parkinsons, and #FTD. @Ali_bioinformtx maps the shared and disease-specific plasma proteomic landscape of neurodegeneration @WashUNeurology nature.com/articles/s4159…
With 40,000 blood and CSF samples, the GNPC’s neurodegeneration proteomics dataset is the largest disease-specific effort yet. #alzheimersdisease @_neuroproteome ow.ly/s0Ks50WhQbs
Our new study by @DuSiling reveals how CSF1R mutations in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) disrupt glial homeostasis. Key roles for oligodendrocytes, astrocytes & STAT3 signaling. nature.com/articles/s4159…
The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway: @ImmunityCP cell.com/immunity/fullt…
Neurons are cool, but do you work with something cooler and understudied like the Blood-Brain Barrier? As a Guest Editor, I invite you to submit manuscripts in the Brain-Immune-Vascular interface for NPJ Dementia! More info at: nature.com/collections/ih… #Neuroscience #Alzheimer
The @karchlab demonstrate that MAPT mRNA and tau protein are expressed in microglia in human brains and in hiPSC-derived #microglia like cells. 🧠 💡Learn more in their new @molpsychiatry study: go.nature.com/447xVwS
Decoding extracellular matrix–lysosome cross-talk and its implications for neurodegenerative diseases | Science Signaling science.org/doi/10.1126/sc…
Excited to share a new preprint out from the lab (biorxiv.org/content/10.110…) by 1st-author @brittany_hemmer , a newly minted PhD from the lab! A brief thread on what we found (1/n):
WashU Medicine continues to unite the world’s most innovative researchers. We’re proud to introduce Jennifer Phillips-Cremins, PhD, to our team — a global leader in 3D genome structure and its role in brain development and healthy function. source.washu.edu/2025/06/philli…
Microglial STING is a central safeguard against neurological decline with age: Cell Reports cell.com/cell-reports/f…
Do you care about #Alzheimer disease research (or research on human diseases generally)? Some of the best scientists in the field are at universities that have received no NIH funding since April, with no end in sight. grant-watch.us/posts/trends-i…
Should PIs at institutions where NIH funds have been frozen still agree to participate in NIH study sections?
Pre-print alert on #tangle maturity in #Alzheimers ✅ 15 #tau antibodies ✅ human #hippocampus ✅ manual tangle maturity scale ✅ #pathomics approach to automate ✅ neuritic and tangle-bearing tau biorxiv.org/content/10.110… If you have not checked out @Google's @NotebookLM ,…
🎉 New paper alert! Congrats Courtney Lane-Donovan and team on the latest publication in Alzheimer’s & Dementia: "Tau phosphorylation at Alzheimer's disease biomarker sites impairs its cleavage by lysosomal proteases" 🧠🧪alz-journals.onlinelibrary.wiley.com/doi/10.1002/al… #Neuroscience #CWOW
New TYP lab publication led by PhD student @alexlish47 out today in @CellReports! We present a reproducible neuron-astrocyte-microglia tri-culture model to study intercellular interactions in Alzheimer's disease. Read more here: cell.com/cell-reports/f…
Lemborexant, a dual orexin receptor antagonist, ameliorates tau-mediated sleep loss and neurodegeneration in males in a mouse model of tauopathy nature.com/articles/s4159…