Young-Pearse Lab

@YoungPearseLab

The Young-Pearse lab focuses on the identification of the mechanistic causes of neurodegenerative and neurodevelopmental disorders. Account run by lab members.

Boston, MA

Joined August 2012

181Following

533Followers

Young-Pearse Lab@YoungPearseLab · Jul 11

Huge congrats to Zack Murphy, selected as a 2025 Fujifilm Fellow at @harvardmed !! 🎉 The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences! Look out for big things ahead from Zack!

YoungPearseLab's tweet image. Huge congrats to Zack Murphy, selected as a 2025 Fujifilm Fellow at @harvardmed !! 🎉

The Fujifilm Fellowship Program fully funds PhD students doing groundbreaking work in the life sciences! Look out for big things ahead from Zack!

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Young-Pearse Lab@YoungPearseLab · Jun 13

Huge shoutout to our brilliant graduate student @GizemTerzioglu_ for delivering a great HMS Neurobiology Pizza Talk! 🍕🧠 She highlighted exciting insights into how SHIP1 shapes microglial function at the intersection of intracellular trafficking and immune response.

YoungPearseLab's tweet image. Huge shoutout to our brilliant graduate student @GizemTerzioglu_ for delivering a great HMS Neurobiology Pizza Talk! 🍕🧠 She highlighted exciting insights into how SHIP1 shapes microglial function at the intersection of intracellular trafficking and immune response.

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Young-Pearse Lab@YoungPearseLab · Jun 13

🧠 New study in @Brain1878, led by graduate student Courtney Benoit, uncovers how the autism-linked gene POU3F2 supports brain development by promoting neural stem cell growth via Wnt signaling and key targets like ADNP and SOX13 academic.oup.com/brain/advance-…

YoungPearseLab's tweet card. Using cellular models of human brain development, Benoit et al. investigate the role of POU3F2, a transcription factor that has been implicated in neurodev

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Young-Pearse Lab@YoungPearseLab · Jun 12

Highlights from our lab at the @KeystoneSymp Neurodegeneration meeting! @Heuerwego delivered an excellent talk on ABCA7 loss and microglial dysfunction in Alzheimer’s! @alexlish47 presented a great poster on CLU and intercellular communication in Alzheimer’s!

YoungPearseLab's tweet image. Highlights from our lab at the @KeystoneSymp Neurodegeneration meeting!

@Heuerwego delivered an excellent talk on ABCA7 loss and microglial dysfunction in Alzheimer’s!

@alexlish47 presented a great poster on CLU and intercellular communication in Alzheimer’s!

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Young-Pearse Lab@YoungPearseLab · Jun 5

New TYP lab publication led by PhD student @alexlish47 out today in @CellReports! We present a reproducible neuron-astrocyte-microglia tri-culture model to study intercellular interactions in Alzheimer's disease. Read more here: cell.com/cell-reports/f…

YoungPearseLab's tweet card. Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes, and neurons to investigate intercellular communication across different environmental and genetic contexts....

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Young-Pearse Lab@YoungPearseLab · Jun 4

Proud of our amazing postdoc @Heuerwego 👏 who gave a fantastic talk today on her work leveraging stem cell models 🧫to examine the molecular and functional consequences of Alzheimer's disease genetic risk in microglia today as part of the BWH Neuroscience Seminar Series!

YoungPearseLab's tweet image. Proud of our amazing postdoc @Heuerwego 👏 who gave a fantastic talk today on her work leveraging stem cell models 🧫to examine the molecular and functional consequences of Alzheimer's disease genetic risk in microglia today as part of the BWH Neuroscience Seminar Series!

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Young-Pearse Lab@YoungPearseLab · Jun 4

We are proud to celebrate Tracy as the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award! 🎉 Her guidance, encouragement, and dedication mean so much to all of us. Congratulations on this well-deserved honor!

YoungPearseLab's tweet image. We are proud to celebrate Tracy as the recipient of the Harvard Medical School Clifford Barger Excellence in Mentoring Award! 🎉 Her guidance, encouragement, and dedication mean so much to all of us. Congratulations on this well-deserved honor!

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Young-Pearse Lab@YoungPearseLab · Jun 3

Thrilled to celebrate our incredible undergrad Ellie Grogan, who was awarded the Harvard Hoopes Prize for her exceptional senior thesis! 🏆📖 We’re so proud of her hard work and insight, and a great time taking her out to dinner to celebrate! 🎉🍽️

YoungPearseLab's tweet image. Thrilled to celebrate our incredible undergrad Ellie Grogan, who was awarded the Harvard Hoopes Prize for her exceptional senior thesis! 🏆📖 We’re so proud of her hard work and insight, and a great time taking her out to dinner to celebrate! 🎉🍽️

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Young-Pearse Lab@YoungPearseLab · May 31

🎓Congratulations to our incredible grads! 🎉 Dr. Lish and outstanding undergrads Seohyun Kim & Ellie Grogan are officially Harvard alumni! 🥂 We’re so proud of all you’ve accomplished—and can’t wait to see what you do next! 💫 @alexlish47

YoungPearseLab's tweet image. 🎓Congratulations to our incredible grads! 🎉
Dr. Lish and outstanding undergrads Seohyun Kim &amp; Ellie Grogan are officially Harvard alumni! 🥂
We’re so proud of all you’ve accomplished—and can’t wait to see what you do next! 💫 @alexlish47

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Young-Pearse Lab@YoungPearseLab · May 30

Huge congrats to our Master’s student Emma Karp for receiving the GBM Master Prize from the Society for Biochemistry and Molecular Biology! 🏆🧬 Emma earned it for her work in Biomedical Neurosciences at TUM! 🎓🧠 🔗 gbm-online.de/de/studium-kar…

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Young-Pearse Lab Retweeted

Rush Alzheimer's Disease Center@rushalzheimers · May 21

With the support of Dr. Frank Ondrey, the RADC is pleased to present the Martha Ondrey Postdoctoral Prize to Sarah Heuer, PhD. Dr. Heuer presented on leveraging human stem cells to elucidate how polygenic risk affects cellular state transitions & communication networks in AD.

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Young-Pearse Lab@YoungPearseLab · May 21

Shoutout to our lab at the ROSMAP meeting! Thanks David and the great team at @rushalzheimers for a great meeting! 🎉 @Heuerwego gave a great talk & won the Martha Ondrey Jr. Investigator Award 🏆 🧠 @GizemTerzioglu_ crushed it with her presentation on SHIP1 & the inflammasome!

YoungPearseLab's tweet image. Shoutout to our lab at the ROSMAP meeting! Thanks David and the great team at @rushalzheimers for a great meeting!
🎉 @Heuerwego gave a great talk &amp; won the Martha Ondrey Jr. Investigator Award 🏆
🧠 @GizemTerzioglu_ crushed it with her presentation on SHIP1 &amp; the inflammasome!

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Young-Pearse Lab@YoungPearseLab · May 21

Well deserved!! We are super lucky to have an amazingly dedicated mentor. Congratulations Tracy!

BBrigham and Women's Neurology@BWHNeurology · May 21

Congratulations to Dr. Tracy Young-Pearse on receiving a 2025 A. Clifford Barger Excellence in Mentoring Award from @harvardmed @YoungPearseLab

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Young-Pearse Lab@YoungPearseLab · May 15

Excited to see our recent study featured on @alzforum! Thank you for highlighting our new study on how AD risk variants at the CLU locus lower astrocytic clusterin, disrupt neuroimmune crosstalk, and drive synapse loss. Read it here: alzforum.org/news/research-…

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Young-Pearse Lab@YoungPearseLab · May 14

A big day for the TYP lab! Master's student @emma_601_emma successfully defended her incredible thesis work today where she's been working with @GizemTerzioglu_ on studying how SHIP1 regulates lysosomal function in microglia. She will be missed!

YoungPearseLab's tweet image. A big day for the TYP lab! Master's student @emma_601_emma successfully defended her incredible thesis work today where she's been working with @GizemTerzioglu_ on studying how SHIP1 regulates lysosomal function in microglia. She will be missed!

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Young-Pearse Lab@YoungPearseLab · May 14

TYP-ers attended the BIGG meeting at UMass on Monday, and had a great time presenting talks and posters! PhD student @GizemTerzioglu_ & postdoc Kellie gave amazing short talks, Master's student @emma_601_emma & postdoc @Heuerwego got great poster traffic!

YoungPearseLab's tweet image. TYP-ers attended the BIGG meeting at UMass on Monday, and had a great time presenting talks and posters! PhD student @GizemTerzioglu_ &amp; postdoc Kellie gave amazing short talks, Master's student @emma_601_emma &amp; postdoc @Heuerwego got great poster traffic!

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Young-Pearse Lab@YoungPearseLab · May 10

Tracy gave a great talk at the 3rd Targeting Therapy of Alzheimer’s and Related Neurodegenerative Disease Conference in Chania, Crete! Huge thanks to Peter St. George-Hyslop, Li-Huei Tsai & Riqiang Yan for an incredible meeting. So many inspiring talks! #TargetAD25

YoungPearseLab's tweet image. Tracy gave a great talk at the 3rd Targeting Therapy of Alzheimer’s and Related Neurodegenerative Disease Conference in Chania, Crete! Huge thanks to Peter St. George-Hyslop, Li-Huei Tsai &amp; Riqiang Yan for an incredible meeting. So many inspiring talks! #TargetAD25

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Young-Pearse Lab Retweeted

John Lukens@LukensJohnR · Apr 30

CLU alleviates Alzheimer’s disease-relevant processes by modulating astrocyte reactivity and microglia-dependent synaptic density: @NeuroCellPress cell.com/neuron/fulltex…

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Young-Pearse Lab Retweeted

Alex Lish@alexlish47 · Apr 30

Thrilled to share my first first-author paper is out in @NeuroCellPress! We show that Alzheimer's disease protective CLU alleles upregulate CLU in response to neuropathology, dampening inflammatory signaling between microglia and astrocytes. Read here sciencedirect.com/science/articl…

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Young-Pearse Lab@YoungPearseLab · Apr 30

New TYP lab paper out today in @NeuroCellPress led by PhD student @alexlish47! We took a deep dive into the mechanisms underlying CLU in AD using innovative iPSC, mouse, and human data approaches. Be sure to give it a read! cell.com/neuron/abstrac…

YoungPearseLab's tweet card. Lish et al. reveal that AD-protective CLU alleles enhance CLU upregulation in response to accumulated neuropathology, thereby dampening inflammatory signaling between microglia and astrocytes. Using...

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