Junedh M. Amrute

In ⁦@Nature⁩ we use single cell multiomics, fibroblast fate tracing, and in vivo models to characterize immune fibroblast crosstalk in heart failure with ⁦@LavineLab⁩ ⁦@washumedicine⁩, ⁦⁦@Amgen⁩ , and ⁦@ImmunoFibHF⁩ nature.com/articles/s4158…

Single cell omics, initially conceived as a research tool, will have more impact in clinical medicine than was ever envisioned cell.com/cell/fulltext/…

Great victory for India at Edgbaston. Fearless and kept pushing England to the wall. Brilliantly led by Shubhman with the bat and in the field and impactful performances from everyone. Special mention to Siraj and Akash for the way they bowled on this pitch. 👏🇮🇳 @ShubmanGill…

Our Spatial Transcriptomics study of human #aortic full thickness punches shows smooth muscle cell clusters in early atherosclerotic #plaque, and an iron-driven macrophage-like cell state that can be targeted to prevent progression @10xGenomics @TheFooLab biorxiv.org/content/10.110…

Very glad to see our recent work in press at @CircAHA . Alternatively activated macrophages driven by IL-4 signaling sustain a parainflammatory response in the failing heart. Kudos to @QiongxinWang for her tireless work on this study

Scientists have found that C/EBP⍺ activates an IRF8 #enhancer, driving its expression in early myeloid progenitors and specifying type I conventional #DendriticCell lineage. @washu_pathology @JingNeticist Read more in Science #Immunology: scim.ag/3EUH8jF

Murphy Lab Bay #2: proving that science and chaotic shenanigans can coexist. 🙌 @SunnyKimNov2016

Sicklinger & colleagues developed a new #ultrasound-guided method to induce #HeartAttacks in mice, allowing precise control & real-time monitoring without the need for invasive surgery. Learn more at ahajrnls.org/42R7ZGs @volkersmirko @junedh_amrute @rkramann

What constitutes the parainflammatory response in heart failure? Our latest work shows the importance of alternatively activated macrophages in driving heart failure ahajournals.org/doi/10.1161/CI… #cardioimmunology @QiongxinWang

Amazing…Tumor-Infiltrating Clonal Hematopoiesis | New England Journal of Medicine nejm.org/doi/full/10.10…

In @Circres we describe a novel Echocardiography-Guided Method for Induction of Myocardial Ischemia/Reperfusion. Check out the full study here: doi.org/10.1161/CIRCRE… Great collaborative effort with @leuschnerlab, @lavinelab, @jacksonlab @rkramann @dzhk_germany @ImmunoFibHF

Rational discovery of VHL molecular glues. New Preprint from @Amgen Induced Proximity group led by postdoc Jonathan Bushman reports the discovery of a VHL molecular glue degrader of GEMIN3 by Picowell RNA-seq. Read on for details. 🧵1/7 biorxiv.org/content/10.110…

JCI - Maintenance of graft tissue-resident Foxp3+ cells is necessary for lung transplant tolerance in mice jci.org/articles/view/…

Excited to see our first-in-human Phase 1 data presented to the cardiovascular community for the first time at ACC 2025. Important step on the way to bringing macrophage checkpoint inhibitors to the clinic! Way to go Alex and team!

Excited to share this work from the Garcia Lab out today in @NatureComms! We engineer "cytokine adaptors", molecular switches that simultaneously block a target cytokine while inducing local activation of alternative cytokine receptors. rdcu.be/ec7GS

It was a really great week for human genetics, multiomics, and precision medicine. Some interesting reads and incredible resources🧵 1⃣From a GWAS in dogs to the discovery of a new obesity target in humans! Variants in DENND1B were the strongest GWAS signal for obesity in 241…

Online now! @pottslab @Amgen demonstrate proof-of-concept of disease-specific targeted degradation by redirecting virally encoded E3 ubiquitin ligases with VIPER-TACs. dlvr.it/TJMyVF #chembiol

We show that graft TREM1/3 signaling within CCR2+ donor macrophages enhances alloimmunity after heart transplantation with Yuriko Terada, Wenjun Li, Amir Bery from Kory Lavine and Dan Kreisel sciencedirect.com/science/articl…