Julian Mutz

We just published a new preprint on biological ageing in individuals with mental and behavioural disorders 🧵Using data from >225,000 @uk_biobank participants, we investigated differences in metabolomic ageing associated with 45 mental disorders

Even small amounts of exercise are associated with a significant reduction in depression.

They played Hans Zimmer’s Interstellar soundtrack in Cologne Cathedral. Surreal.

Lifetime risk and projected burden of dementia 👉The lifetime risk of dementia after age 55 years was 42% nature.com/articles/s4159…

Victoria Station, London, 1960s.

Pleased to be able to contribute to this huge international effort led by @RikOssenkoppele and colleagues @biofinder_study exploring tau PET in n=12,048 individuals *open access* paper here: nature.com/articles/s4159…

People with low grip strength have up to 3× higher mortality risk —Lancet, 2015

When the weather gets hot, mortality risk skyrockets for Europeans, but not Americans. This is likely because more than 90% of Americans have air conditioning, compared to just under 20% of Europeans. Europe should adopt A/C.

The immune system and brain are uniquely associated with healthspan and longevity, the latest insights from organ clock proteomics @NatureMedicine @wysscoray nature.com/articles/s4159…

That .8 at the end would change my life

2025 is 50% complete.

New paper from Julian Mutz extending his metabolic aging clocks to examine whether people with mental disorders show differences in metabolomic ageing.

Alzheimer's disease (AD) risk at various polygenic score (PGS) percentiles compared to median group (40-60%). In addition to APOE, other risk variants as well contribute significantly to AD risk, independent of APOE (but clearly APOE is the single most important risk factor in…

Type 2 diabetes affects up to 14% of the global population. This Review discusses the diagnosis, treatment, and prognosis of adults with type 2 diabetes. ja.ma/3TQ3Z3m @ADA_DiabetesPro