Joshua Meier
@joshim5
Co-Founder at Chai Discovery
I've been working on variants of this problem for my entire career, and have only dreamed of designing molecules on the computer with success rates this high. Proud of @chaidiscovery for pulling this off, and doing it with the speed, rigor and grace that was only imaginable ✨
We’re excited to introduce Chai-2, a major breakthrough in molecular design. Chai-2 enables zero-shot antibody discovery in a 24-well plate, exceeding previous SOTA by >100x. Thread👇
🎉 Congratulations to @ZhuoranQ for winning the Chen Institute and @ScienceMagazine AI Prize, recognizing his groundbreaking AI research in biochemistry. We’re honored to have him on the @chaidiscovery team!
Congratulations to the winners of the 2024 Chen Institute and @ScienceMagazine AI Prize! Winners share $50,000 in cash awards and their research essays will be published in Science. Learn more about grand prize winner @ZhuoranQ and finalists @Roobaert_Alizee and @neuronair here:…
Chai-2 is now up on BioRxiv: biorxiv.org/content/10.110…
Zero-shot antibody design in a 24-well plate @chaidiscovery 1. Researchers have introduced Chai-2, a multimodal generative model that marks a significant leap in de novo antibody and miniprotein design. This platform achieves an impressive 16% hit rate in de novo antibody…
Thank you for having us on the show! I've been a long time listener of @NoPriorsPod. It was fun to catch up with @saranormous and @_jackdent to talk more about Chai-2 and what's coming next.
🆕!! AI and atomic-level structure prediction are accelerating drug discovery — turning a slow, empirical search process into something closer to molecular engineering. @joshim5 @_jackdent co-founders @chaidiscovery chat their new bio foundation model, Chai-2. It enables…
This is a massive understatement. @Mattmcpartlon1’s brilliance is unparalleled. But he’s also an incredibly thoughtful, disciplined and caring leader. Every day working with @Mattmcpartlon1 challenges me & the company to think bigger, work harder, and show up stronger. 🖤
Mark my words, @Mattmcpartlon1 will go down as alec radford/noam shazeer of Bio x AI, he's just built different. Congrats to the team! I don't think people outside the field realize how much progress has accelerated in the last 2 years. Vibes are different.
I appreciate Chai’s hard work to ensure my predictions are accurate.
We’re excited to introduce Chai-2, a major breakthrough in molecular design. Chai-2 enables zero-shot antibody discovery in a 24-well plate, exceeding previous SOTA by >100x. Thread👇
We've just passed the Singularity moment for molecular engineering. This might be the most important thing you read today. Chai-2 can design an antibody in seconds that previously took researchers months or years, with ~20% zero shot success rate. Congratulations to the team!
We’re excited to introduce Chai-2, a major breakthrough in molecular design. Chai-2 enables zero-shot antibody discovery in a 24-well plate, exceeding previous SOTA by >100x. Thread👇
THIS is what gets me excited about AI! Using generative techniques to solves previously computationally intractable problems is the real superintelligence. When this is more mature it'll give us unprecedented control over our biology. So cool.
We’re excited to introduce Chai-2, a major breakthrough in molecular design. Chai-2 enables zero-shot antibody discovery in a 24-well plate, exceeding previous SOTA by >100x. Thread👇
NEW: The OpenAI-backed biotech startup Chai Discovery announced a new suite of AI models today, called Chai-2 The main result: making de novo antibodies with a 19% hit rate on average, which @zavaindar called "fucking killer" endpoints.news/openai-backed-…
Some use cases are cooler than others, and it's safe to say zero-shot antibody design is one of them. Congrats on launching Chai-2!🧬
Big thank you to stellar engineering team at @modal_labs, who provided some critical infrastructure for this effort. They are a joy to work with.
I'll be going on @tbpn at 1:30pm PST today to talk about Chai-2 and what's next for us @chaidiscovery. Make sure to tune in!
Morning. Here are our guest call-ins today: – @willccbb (Prime Intellect) – @willobri (Ulysses) – @joshim5 (Chai Discovery) – @john__glasgow (Campfire) See you all on the stream.
Congratulations to @chaidiscovery on this incredible milestone. We are proud to have partnered with the Chai team on some of the extensive experimental validation in the linked paper.
We’re excited to introduce Chai-2, a major breakthrough in molecular design. Chai-2 enables zero-shot antibody discovery in a 24-well plate, exceeding previous SOTA by >100x. Thread👇
Chai Discovery just released their new model Chai-2, validated on Adaptyv! Chai-2 enables generation of de novo proteins and epitope-specific antibodies using a multimodal generative architecture that integrates all-atom structure prediction and generative modeling. Chai…
We’re excited to introduce Chai-2, a major breakthrough in molecular design. Chai-2 enables zero-shot antibody discovery in a 24-well plate, exceeding previous SOTA by >100x. Thread👇
We're excited to partner with the UK Government on OpenBind, an effort to create the largest open dataset of drug-protein interactions in history. More data → smarter AI models → better medicines gov.uk/government/new…
Welcome to the team, Zhuoran! @ZhuoranQ is an AI-bio legend, having led the development of NeuralPlexer1-3. I've been following Zhuoran's work for a long time and it's great pleasure to now work together at @chaidiscovery. Welcome aboard! 🚀
Life update - I have joined Chai Discovery as part of the founding team earlier this year! A rather belated announcement, but I want to take the time to thank all friends, share some reflections, and talk more about things ahead that excite me most. Post: substacktools.com/sharex/EYdWWDAZ
Exciting news! 🎉You can now try Chai-1, the SOTA model for biomolecular structure prediction by @chaidiscovery, with Seqera! 👉 Check it out: github.com/seqeralabs/nf-…
Excited to announce the general availability of Chai-1 in SAMSON! Like AlphaFold 3, Chai-1 is a state-of-the-art foundation model for biomolecular structure prediction which handles proteins, small molecules, DNA, RNA, glycosylations, etc. One particularly exciting feature is the…