Jason Liang

Thanks from my deep heart to @puigserver_lab @PpuigserverB, Kai Wucherpfennig, Hans Widlund, Jean Zhao, and everyone at @DFCI_CancerBio and @harvardmed for your mentorship and support. Excited for what’s ahead!

Thrilled to share that I’ll be starting my new position as a tenure-track assistant professor at the @OSU Comprehensive Cancer Center on July 1st! And to continue my journey to conquer cancer through the lens of metabolism and immunity.

New studies from our lab published in @CellChemBiol designing anti-diabetic metabolic routes using novel small molecules (SR-18292) that re-direct lactate and gluconeogenic carbon substrates to mitochondrial oxidation cell.com/cell-chemical-…

Excited to share our latest preprint by postdoc @platorremuro in collaboration with @vivekvivsharma and #LiaoLab. We combined #physiology and #cryoem to determine respiratory supercomplex adaptation in brown adipocytes in response to cold environments: biorxiv.org/content/10.110…

New studies from @puigserver_lab at @DFCI_CancerBio @HarvardCellBio finding Mitoribosome Quality Control as protective mechanism against pathogenic human mitochondrial disease mutations, published @emboreports embopress.org/doi/full/10.15…

New studies from @puigserver_lab published in @Cell_Metabolism show that liver mitochondrial cristae architecture protects against diet-induced obesity increasing energy expenditure and locoomotion sciencedirect.com/science/articl… @DFCI_CancerBio @HarvardCellBio @BanksLab @GygiLab

Our latest studies published now in Nature Communications, in collaboration with Steve Gygi's and Widlund Hans' labs. Vulnerabilities of BRAFi-resistant melanomas to HMGCR statin inhibitors.nature.com/articles/s4146…

Our latest paper published now in @NatureComms: Epigenetic suppression of PGC1α can sensitize BRAFi-resistant melanomas to HMGCR inhibitors, check it out! nature.com/articles/s4146… @DFCI_CancerBio @HarvardCellBio @GygiLab @bwhdermatology

We are looking for strong candidates with backgrounds in cell biology, biochemistry, metabolism, immunology, cancer biology, chemical biology or structural biology. More information about us can be found on our website: puigserver.dfci.harvard.edu 2/2

We are hiring! Our lab has several openings for #postdoc fellows in projects looking at mechanisms of mitochondrial disease and cancer immunology in a great research environment. Direct inquiries to [email protected]. Please RT! @HarvardCellBio @mitojobs 1/2

Three cells going through cell division videoed through a microscope. Left to right: Control, Myosin IIA depletion, and Myosin IIB depletion. This data screamed, "Study membrane blebs!" So we did.... #CellBiology #Biology #Science cell.com/cell-reports/f…

2-Deoxy-D-glucose couples mitochondrial DNA replication with mitochondrial fitness and promotes the selection of wild-type over mutant mitochondrial DNA | Nature Communications nature.com/articles/s4146…

Beautiful lion mane

CDK8 selectively promotes the growth of colon cancer metastases in the liver by regulating gene expression of TIMP3 and matrix metalloproteinases. - PubMed - NCBI ncbi.nlm.nih.gov/pubmed/30185549