FrezzaLab

This is a topic I am very passionate about, and something I am learning every day. I hope you will enjoy the read, and you will find it useful. Happy to hear your views about the topic. The mindful scientist network.febs.org/posts/the-mind… #FEBSnet

Today we are publishing 2 MANUSCRIPTS in @NatureComms 1. @NataliaPardoL discovers the role of nuclear MTHFD2 in centromere stability 2. Espinar and Garcia-Cao reveal the role of nuclear IMPDH2 in the DNA damage response. Nuclear Metabolism is on 🔥

New study from us: science.org/doi/10.1126/sc… High mtDNA copy number promotes lung cancer growth in the mouse, whereas mtDNA depletion in tumor cells reduces tumor growth. This tumor-intrinsic role for mtDNA can be exploited for development of future lung cancer therapies.

💡Exciting news! Our latest study, in collaboration with Prof. Mirela Kuka’s lab, is out now—uncovering how T cell–derived IFN-γ can suppress T follicular helper (TFH) cells and limit antibody responses. 🚀🧵(1/10) embopress.org/doi/full/10.10… 🔬Approach: We used a subcutaneous LCMV…

This is a huge decision from the Guardian. I believe too that X has become a polarised political platform that has lost its purpose and sadly, I no longer support it, despite its initial good intention. I will move my activity to @frezzalab.bsky.social theguardian.com/media/2024/nov…

#Circadian disruption in #cancer hallmarks: Novel insight into the molecular mechanisms of tumorigenesis and cancer treatment sciencedirect.com/science/articl…

🥳 Happy to share our new preprint where we describe the molecular machinery regulating iron transport between lysosomes and mitochondria, how it controls the melanoma drug tolerant persister state and the consequences of its perturbation on ferroptosis 👉 researchsquare.com/article/rs-534…

Today in @CellCellPress we report a new pathway of ketone metabolism. This BHB shunt generates an orphan family of anorexigenic ketone metabolites that are chemical cousins of exercise-inducible Lac-Phe. Congratulations @mariadolores_mg @Stanford_ChEMH cell.com/cell/fulltext/…

Fantastic opportunity to work with a great mentor on a very fascinating topic! 🔥🔥🔥

🔬 FEBS Open Bio Webinar: Mitochondrial Biogenesis: An in-depth look into the beating heart of the eukaryotic cell 🗓️19th November at 16:00 CET ➡️zoom.us/webinar/regist… ➡️ network.febs.org/posts/upcoming… #mitochondria #webinar #FEBSOpenBio #YoungFEBS #FEBS_JS #febsjuniorsection

Last week's papers on #glutamine #cancer and #metabolism via @Bims_BiomedNews biomed.news/bims-glucam/20… Top pick: Glutamine modulates neutrophil recruitment and effector functions during sterile inflammation pubmed.ncbi.nlm.nih.gov/39504570/

ICYMI. The #hallmarks of #cancer #immunoevasion. After the 3 Es, the #3Cs, a new framework from @ClaudiaGalassi9 @IlioVitale @GeneCollector and co. On the cover of @cancer_cell Beatiful design by Cris Iribarren offtwitter. Available at cell.com/cancer-cell/fu… @FoxChaseCancer

📢Last two weeks of #immunometabolism discoveries @Bims_BiomedNews ⬇️⬇️⬇️ biomed.news/bims-imicid/20… biomed.news/bims-imicid/20…

Out today @NatureAging ! Life stress can accelerate aging and shorten lifespan, but how remains unclear. We identify that hippocampal/cortical neurons acquire features of p16-dependent #senescence and DNA damage in mice exposed to chronic social stress. nature.com/articles/s4358…

If your world feels ripped apart and research seems suddenly pointless, see this week’s Science Without Anguish post! 🧪 ‘Healing the wounds: why science and research culture matter more than ever now’ sciencewithoutanguish.com/blog/healing-t… Please tell colleagues, on or off social media.

In academia, we often hear about the importance of networking, but the focus is usually on professional connections. Here, I present a different angle of networking, one that is often overlooked but equally important (if not even more important): your network of support. The…

I was born in 90s and my brother 2010s. This is so accurate lmao

🇨🇭Happy Sunday from Switzerland! This week's #MicrogliaResearch in Health and Disease edition, supported by @Bims_BiomedNews, is now available! As a scientist passionate about Microglia, I’m excited to share my curated selection of publication highlights with you each week.…

This week selection of papers in myeloid leukemia biology and therapy is out. Enjoy it and thanks as always @Bims_BiomedNews biomed.news/bims-tremyl/20…

It's Sunday again and a new issue of #cebooc is out! Pick your favourite paper on #oocyte cell #biology here: biomed.news/bims-cebooc/20… This week's highlight is @abalboula1 work on DNA damage and autophagy in oocytes: pubmed.ncbi.nlm.nih.gov/39487138/ Thanks to @Bims_BiomedNews for…