Jessica Andreani
@jessica_compbio
Researcher in comp bio Prot-prot & prot-RNA interactions, struct & evol Also mum Personal account @[email protected] @jessicaandreani.bsky.social
New preprint 🚨 We investigated how protein-RNA interface structure evolves by thoroughly analyzing the conservation of contacts among 2022 pairs of homologous interfaces. Work with Ikram Mahmoudi, Chloé Quignot, Carla Martins @I2BCParisSaclay @CEA_Joliot
Structural comparison of protein-RNA homologous interfaces reveals widespread overall conservation contrasted with versatility in ... biorxiv.org/cgi/content/sh… #biorxiv_bioinfo
OUT NOW in @Nature: A bacterial immunity protein directly senses two disparate phage proteins By Tong Zhang, Abel Garcia-Pino, Michael Laub & colleagues. @michael_laub8 nature.com/articles/s4158…
🧬 Comprendre les interactions protéine-ARN pour ouvrir la voie à de nouvelles approches thérapeutiques. Le projet ESPRINet, mené par des scientifiques de l’@I2BCParisSaclay, vise à élucider les mécanismes moléculaires sous-jacents de ces interactions. ▶ lejournal.cnrs.fr/nos-blogs/focu…
L’I2BC quitte Twitter. Retrouvez-nous sur Bluesky @i2bcparissaclay.bsky.social pour suivre nos actualités scientifiques @CEAParisSaclay,@CNRSbiologie,@UnivParisSaclay
We’re so exited about the community’s use of Boltz-1 already! We’ve just released a new update to of the Boltz-1 repo, which now automatically generates MSA’s for users in seconds using the amazing Colabfold MMseqs server. Test it out here: github.com/jwohlwend/boltz
The Evo 1 paper is now published!
A new Science study presents “Evo”—a machine learning model capable of decoding and designing DNA, RNA, and protein sequences, from molecular to genome scale, with unparalleled accuracy. Evo’s ability to predict, generate, and engineer entire genomic sequences could change the…
A couple years ago I tried to get structural biology people to migrate to 🦋 by handing out invites which were in short supply. It worked for a bit but there wasn't much engagement there. Everything has changed in the last week. So please join us there.
Today we report in @NatureBiotech a system for the laboratory evolution of engineered virus-like particles (eVLPs) that enables the discovery of eVLP variants with desired properties, including improved production and delivery potency. 1/13 PDF: drive.google.com/file/d/1E6Nr86…
Protenix - Yet another reproduction of AF3 github.com/bytedance/Prot…
Protenix: Protein + X | ByteDance - A trainable PyTorch reproduction of AlphaFold 3 GitHub: github.com/bytedance/Prot…
Remember Golden Gate Claude? @etowah0 and I have been working on applying the same mechanistic interpretability techniques to protein language models. We found lots of features and they’re... pretty weird? 🧵
This could be a good time to remind those that may have not seen it before, that the @reactome database at @emblebi also has a library of open access icons reactome.org/icon-lib
🚨 New preprint alert! 🚨 We're excited to share our latest work: "Towards a complete phage tail fiber structure atlas" 🦠🔬 of first author @VKleinSousa We developed #RBPseg for segmenting and merging phage tail fibers using structural prediction tools. tinyurl.com/58cn2ew7
This is great! @NIAIDNews have launched a collection of public domain illustrations (currently 550 individual icons) bioart.niaid.nih.gov
AI has dreamt up a blizzard of new proteins. Do any of them actually work? go.nature.com/48oAeNX
Much of the success of breakthroughs, such as AlphaFold, is thanks to a database of protein structures dreamed up in the 1960s by Helen Berman go.nature.com/4hp4UCP
You still have a couple of weeks to submit an abstract for our next #LEGO meeting day in Paris! gt-lego.cnrs.fr/animation/lego…
DENSE is out! Mine your genome and highlight its de novo genes :D
De Novo Emerged Gene Search in Eukaryotes with DENSE | @scoopit sco.lt/8RJ9yS @anne__lopes @GenomeBiolEvol #denovogenes
Join us in Paris on April 8th-10th for the 2025 Symposium on the Immune System of Bacteria 🥖🍷🦠🧬. Excited to welcome these amazing speakers at @institutpasteur . Registration will open beginning of November. Abstract deadline February 28. Stay tuned.