Isabelle Zane

For years, dog scientists have known that food appears in bowls or rains from the sky, but the exact source and mechanism is unknown. Buster et al observed that barking at an intermediate volume correlates with food appearance, but only at certain times of the day. #sciart

Excited to share our work with @julie_trolle and @JefBoeke We developed a 'shotgun' method to screen millions of synthetic metabolic pathways to enable mammalian cells to grow without two essential nutrients for the first time in >500 million years! biorxiv.org/content/10.110…

Mapping the off-target effects of every FDA-approved drug in existence (EvE Bio) 6.2k words, 29 minutes reading time owlposting.com/p/mapping-the-… this is a very long essay over @EvEBiotech, a data collection effort that you should know about (it's associated w/ @Convergent_FROs!)

this was really great

Today in the journal Science: BioEmu from Microsoft Research AI for Science. This generative deep learning method emulates protein equilibrium ensembles – key for understanding protein function at scale. msft.it/6010S7T8n

It’s wild to think that Sanger sequencing, which famously decoded the first 5,000-base genome of bacteriophage φX174, was invented almost half a century ago. The space has exploded with 10 companies and 37 instruments. If you factor in the different flow cell types and…

7 *insane* bio resurrections - 1. Ancient virus (Pithovirus sibericum) - from 30,000 years ago; Revived from Siberian permafrost; still infectious to amoebae 2. Prehistoric plant (Silene stenophylla) - from 32,000 years ago; Grown from Ice Age fruit tissue; fertile and flowering…

In July 1967, a section of the South Hill neighbourhood of Toronto decided to declare itself an independent republic. It elected a queen, formed an air force of 1,000 helium balloons and issued passports. This is the story of the Republic of Rathnelly! 🧵 1/9

This is so cool! Ancient proteomics can reach further back in time than ancient DNA sequencing. AFAIK dinosaur fossil proteomics has been limited to a few collagen peptides shared with modern birds but this ancient rhino study sheds meaningful light on big stretches of proteins

Beaks have grown longer and larger, and ranges have expanded to follow the feeders. Learn more: scim.ag/45BSZ0W

The proposed analogy between interpreting machine learning and biology really does not hold up at all Understanding biology is hard precisely because it doesn’t have any of the properties that make understanding machine learning models (relatively) easy - full observability, no…

The 3-decade-old competition that enabled the emergence and evaluate of AlphaFold has run out of NIH funding. The program will be terminated in weeks. This is terminating success. science.org/content/articl…

i recently went to a party, and it was very, very cold. so, after an hour of shivering around and holding a drink that i never drank, i decided to leave but on the way out, a woman collided with me, a women dressed head to toe in Rick Owens. i looked closely. her shoes were…

Our lives are limited to an unbelievable degree by our unwillingness to be temporarily low in social status. Embarrassment has been the cost of acquiring every valuable skill I have. If you design your life not to feel it, you're selling yourself short. (More below.)

Adenoviruses, despite their large cargo carrying capacity, have been beat by the much smaller AAV in the gene therapy field. I wrote a summary on why that is (link below.) (hint: having a large genome is a double edged sword in the viral vector space)