Hojong Yoon
@hojong_yoon
Assistant Professor & CPRIT Scholar @MDAndersonNews Interested in Protein degradation, Induced proximity, Small Molecule Drug discovery
My lab at @MDAndersonNews is actively seeking motivated individuals (Postdocs, RAs, Scientists) interested in TPD, induced proximity, or small molecule drug discovery. (1/6)
📢 Save the Date! The next FREE Dana-Farber TPD In-Person Event is coming soon! Join us for an afternoon of cutting-edge science, networking, and community building focused on Targeted Protein Degradation (TPD). Stay tuned for registration and speaker details.
#AACR25 Meetings Highlights session: Thanks to Cory Abate-Shen for summarizing the "fearless chemistry" including degraders and glues to drive new drug discovery efforts. Great coverage of the field also by @HartungIngo and others, much appreciated 👋 See you all at #AACR26
A powerful and personal editorial from Nobel laureate @ardemp: "I owe America my success. Today, its scientific future is in danger." Please read and share. cnn.com/2025/04/09/hea…
Excited to share my graduate work from the @EJohnWherry lab on the molecular mechanisms locking in the differentiation fate of exhausted CD8 T cells (Tex), published earlier this month in @SciImmuno. Main findings below! science.org/doi/10.1126/sc…
A small but meaningful milestone - our lab's first NIH grant NOA! Grateful for the support and excited to get to work! We're hiring! Candidates with experience in biochemistry, assay development, and structural biology are encouraged to apply!
Couldn’t recommend more highly!! @biomiko is a great scientist and mentor, as well as one of the niceaset friends I’ve ever met👍
I am excited to announce the launch of the Slabicki Lab at the Krantz Family Center for Cancer Research within the Mass General Cancer Center and the Cancer Program at the Broad Institute of MIT and Harvard! 🔗 Learn more: slabicki-lab.org
Very excited for our next seminar next week! Yuh Min Chook(@yuhminchook) at UTSW will share an intriguing allosteric mechanism of drug-induced XPO1 degradation, mediated by the CRL5-ASB8 E3 ligase complex. Join us at 12 pm EST (Feb 20th). Preprint - biorxiv.org/content/10.110…
Mind-blowing masterpiece by @brian_b_liau @LabZheng
Today in @Nature we share our back-to-back stories with @nzhenguw revealing chemical-genetic convergence between a molecular glue & E3 ligase cancer mutations. 1/6
Join us for the final TPD webinar of 2024 on 12/19. @FleurMFerguson & @eswang01 - "ZBTB11 Degraders Target Metabolic Vulnerabilities in K-Ras Inhibitor Resistant PDAC" Slava Ziegler - "Targeting IDO1 by monovalent degraders exploiting the native IDO1 degradation mechanism"
Orgchem or biochem folks! How do you manage an enzyme-catalyzed synthesis when your starting material crashes out upon mixing with your protein? It works well on a small scale, but scaling up becomes tricky. Any tips or tricks?
Can't wait!!!
We are thrilled to have @georg_e_winter @CeMM_News return to the DFCI TPD webinar this Thursday! Georg will talk about how inhibitors can supercharge endogenous degradation mechanisms. Very much looking forward! 👉Join us at 12 PM EST/ 6 pm CET (hybrid format)
A must-read! The #DepMap portal is used extensively by the research community to assess gene functions in #cancer, nominate potential therapeutic targets, and identify biomarkers of response. Read in @NatureRevCancer on the present and future of DepMap. nature.com/articles/s4156…