Samuel Hume
@DrSamuelBHume
Iβm a doctor-scientist, I write about progress in medicine
Top 5 advances in medicine this week (π§΅) π. π π‘πππ₯ππ‘π² ππ’π«ππ‘π¬ ππ«π¨π¦ π¦π’ππ¨ππ‘π¨π§ππ«π’ππ₯ ππ¨π§πππ’π¨π§β£ Women with mitochondrial disease can pass the condition to their children β because mitochondria, and the DNA it carries, are exclusively passedβ¦
Ecstatic to announce that I've teamed up with @DrSamuelBHume to write on his Substack breakingground.substack.com aimed at keeping you up to date on developments in medicine! My first article is live, on a potential treatment for an incurable brain disease breakingground.substack.com/p/advances-in-β¦
A breakthrough mouse model, a first-of-its-kind therapy, and what the future might look like: @AndreasHuysman's take on microglial replacement for a fatal neurological disorder We'll keep you up to date with medicine β please subscribe! breakingground.substack.com/p/advances-in-β¦
Ivermectin is an antiparasitic drug that kills mosquitoes feeding on treated persons. In this trial in Kenya, ivermectin given once per month for 3 months led to a 26% lower incidence of malaria than albendazole. Full trial results: nej.md/4lIyNzB Editorial: Ivermectinβ¦
This is very cool: AI helped restore damaged Latin inscriptions (nature.com/articles/s4158β¦)
Probably the most promising use of proteomics in drug development is creating signatures that act as surrogates for hard endpoints in early phase trials. In a MASH trial, semaglutide showed dose-dependent effects on serum proteomic signatures of liver histology mirroring actualβ¦
Today in @CellCellPress we report the use of prime editing to correct several mutations that cause alternating hemiplegia of childhood (AHC), a rare and devastating neurodevelopmental disorder, in patient-derived cells and in two mouse models. drive.google.com/file/d/1ibC50t⦠1/10
𧡠Top 3 News + Advances in Microplastics - Bipartisan Bill to study microplastics' health effects (July 21) πΊπΈπ€πΊπΈ - Microplastic exposure leads to memory decline in mice β οΈπ§ π - Chlorella, a natural algae can remove microplastics from waters π±πͺΈπβ¨