Zubin Sharma MD

Part 1- Understanding the Equipment for Esophageal Manometry and Basics of Impedance @NGMJournal @JNMjournal youtu.be/l7VzNkGxCpY?si…

Why Do Patients Discontinue GLP-1 Medications for Obesity? Adherence Challenges ❌ 50% stop treatment within 6 months Top Reasons for Stopping 🤢 Side effects (mainly GI): 36% 🚗 Logistics (travel, time): 24% 💰 Cost & affordability: 23% dom-pubs.onlinelibrary.wiley.com/doi/full/10.11…

🆕🔥Stereoscopic quantitative analysis of #EntericNervousSystem in patients with #SlowTransitConstipation‼️ 🎯Quantifiable 3D view of #ENS🔥 ✅Reductions in both myenteric plexus density & ganglion density in STC patients👏 👉onlinelibrary.wiley.com/doi/10.1111/nm… @ANMSociety @esnm_eu

It now seems obvious but a great deal of work went into understanding the role of #methane and #contipation now called #IMO, setting up new drug therapy. Here we present the cause and effect evidence for methane causing constipation from @MASTprogram @CedarsSinai #theMAST5years

GALAXI 2 and 3 trials of guselkumab maintenance in patients with Crohns disease just published 🌟Guselkumab superior to placebo and ustekinumab @TheLancet @LancetGastroHep @geteccu @sepdigestiva @aegastro ➡️ thelancet.com/journals/lance…

New online! The global burden of inflammatory bowel disease: from 2025 to 2045 bit.ly/44AOQtc

👩‍⚕️🧑‍⚕️ Starting GI or Foregut fellowship? A solid grasp of esophageal manometry is key to preop planning for antireflux surgery. This review in @foregut_journal discusses: 🔹 Why manometry remains essential before ARS 🔹 How motility data informs surgical choice 🔹 The rationale…

Does your country's GI society support Residents this way? Indian Society of Gastroenterology probably does most for Residents 1st Year - 3 days boot camp on research and basics -YCP 2nd year- 3 day on Theory of Gastroenterology -EBG 3rd year- 3 day drilling camp with mock…

🚨Monthly anti-obesity injection? 💉 💡 A new phase 2 trial in NEJM tests maridebart cafraglutide (MariTide) — a GLP-1 agonist & GIP antagonist combo 🔬 showing promise for long-interval #obesity therapy 💪🏽 🔗 tinyurl.com/3y2y32vh #GITwitter #MedTwitter @NEJM @my_ueg

Is this what tax payers deserve ? We don’t need Disneyland,just give us CLEAN and GREEN Gurugram @MunCorpGurugram @DC_Gurugram @OfficialGMDA @NayabSainiBJP @cmohry @CAQM_Official @byadavbjp @gurgaon_live @diprogurugram1 @MeraGurgaon @GurugramTweets @TheSanjivKapoor @PMOIndia

Risk of Submucosal Invasive Cancer Based on Colon Polyp Morphology Source: Burgess NG, Hourigan LF, Zanati SA, et al. Gastroenterology. 2017;153(3): 732-742.e1.

Tirzepatide and semaglutide are both highly effective for the management of obesity. How the two drugs compare in patients with obesity but without diabetes has been unknown. Research findings from the SURMOUNT-5 phase 3b trial are summarized in a short video.…

🧵 New RCT Alert! In a multicenter trial (n=280), 57.9% of #IBS-D patients responded to #acupuncture vs. 41.4% with #sham (RR 1.40, P = .008). Pain & diarrhea improved by week 3, effects sustained for 18 weeks. Safe, well-tolerated. pubmed.ncbi.nlm.nih.gov/40441496/

GLP-1 RA & Nutritional Deficiencies In a new study of 460k people on GLP-1 RA, it was shown that: 1️⃣ Vitamin D deficiency was most common (13.6%). 2️⃣ 12.7% developed nutritional deficiencies in 6 months. 3️⃣ 22.4% within 12 months. 4️⃣ 8% of people saw a dietitian within 6…

Management of oesophageal and oropharyngeal dysphagia: 🆕 guidance from UEG and ESNM - a must read overview 📌🌟🔢 1️⃣ Causes 2️⃣ Evaluation 3️⃣ Mx of oesophageal dysphagia 4️⃣ Mx of oropharyngeal dysphagia 📸: @UEGJournal @my_ueg @esnm_eu onlinelibrary.wiley.com/doi/10.1002/ue…

Anti Obesity Medications Effect On Bone Metabolism 1️⃣ Weight loss reduces fat, but also muscle and bone. 2️⃣ GLP-1R agonists have minimal or no harmful effects on bones in humans. 3️⃣ Fracture risk remains unchanged with GLP-1R use. 4️⃣ Dual/triple incretin agonists may benefit…

🕵️‍♂️ Look at how many new obesity management medications (OMMs) are on the way! Injectables (daily, weekly, monthly), orals, duals G, triples G... GLP-1 + amylin, GLP-1 + human monoclonal antibody (not in the chart) combos. And interestingly, it’s not just the usual big names, many…

💥Immune checkpoint inhibitors save lives—but can wreak havoc on the gut. Learn how to recognize, work up, and treat immune-related diarrhea & colitis 💊🦠 Clear, practical guidance for medicine, onc & GI teams. 📄 bit.ly/ICIDIARRHEA #MedTwitter #Oncology #GI…

During a case presentation today on cholestatic jaundice, my consultant asked me to state Courvoisier’s law. I quoted it as written in some older papers, but he interrupted me and said that a law should be quoted in exact wording. I tried to explain that the original paper was…

Our group was the first to define POSED (Post-Obesity Surgery Esophageal Dysfunction), a newly recognized motility disorder that can develop in a subset of patients after metabolic bariatric surgery. In our latest @NGMJournal Neurogastroenterology & Motility study, we uncover a…

🚨Excited about our latest 📜 on #ESD techniques: #Tunnel-ESD 🏆 Highest curative rate ✅ Lowest adverse-events #Traction-ESD 🚀Fastest ⏲️ 🎯Superior en-bloc resection #Conventional-ESD 🔄Reliable baseline approach 🩺Tailor your approach Link: thieme-connect.de/products/ejour…