Mark Pimentel MD

September will be the 5th anniversary of @MASTprogram in our current location. It continues to be a privilege to work towards helping patients who suffer. We will post some of the amazing highlights from the past 5 years over the coming weeks.

Today @TheEndoSociety #ENDO2025 we are presenting data that adding Rothia mucilaginosa to the gut induces a #PCOS phenotype and the metabolic changes return to normal after stopping Rothia. @GabrielaGSLeite @RuchiMathurMD @MASTprogram @CedarsSinai

Shocking...not shocking! Bloating is #1 one and pain 3rd in IBS-D patients. That's what I hear every day. Yet the criteria don't even include bloating...ridiculous. As a result, bloating cannot be a primary or secondary endpoint for drug trials. We need to listen to patients.

Haven't done a poll in a while. If you have #IBS-diarrhea, which symptom is your most bothersome?

It now seems obvious but a great deal of work went into understanding the role of #methane and #contipation now called #IMO, setting up new drug therapy. Here we present the cause and effect evidence for methane causing constipation from @MASTprogram @CedarsSinai #theMAST5years

Interestingly, autoimmune hypothyroidism had an even stronger association with #SIBO

Small bowel sequencing technologies are moving us into a modern understanding of #SIBO and its microtypes in conditions such as #IBS. New therapeutics addressing this are about to begin trials.

⭐️Thrilled to share our latest publication! We found that GLP-1 receptor agonists, commonly used for diabetes and weight loss, are associated with the development of small intestinal bacterial overgrowth and intestinal methanogen overgrowth🦠 #GITwitter journals.sagepub.com/doi/10.1177/26…

🔥🦠 SIBO showed up in 1 in 3 patients with alcoholic hepatitis—vs just 3.4% of healthy controls, per @VVaithiyam & team @MAMC_NewDelhi. Findings could open a window to managing #alcoholichepatitis. @CureusMedical #LiverHealth #GutMicrobiome bit.ly/4nAIRMk

We are honored by those who have donated this year to our program. Nothing happens without resources and because of you, new therapies are here and getting ready for human study! Thank you on behalf of the nearly 1 billion people who suffer from the chronic intestinal illnesses…

Paper out! Methane and Hydrogen sulfide on three-gas breath test correlate with methanogens and H2S producers in the SMALL INTESTINE! M. smithii for methane and Proteus and Desulfovibrio for H2S, among others. Methane=constipation, H2S the opposite. doi.org/10.1007/s10620…

In this study, we examine the safety of drugs for #IBS. It turns out that tricyclic antidepressants are among the drugs patients are most likely to stop due to adverse events. journals.lww.com/ajg/abstract/9…

This was a great year! Just recovering from an amazing DDW and gearing up for the next academic funding cycle starting in July. As you can imagine it's different this year. Trying to continue our momentum since we now have the right drugs and targets.

🚨 We're hiring! GI motility program @CedarsSinai is looking for a Clinical Dietitian II to join our multi-disciplinary neurogastromotility team. Passionate about gut health, microbiome, nutrition, and trailblazing innovation? This role is for you. 🔗 careers.cshs.org/job/beverly-hi…

This past #DDW2025 reminded me of article showing that #IBS develops after military deployment. Extreme stress was seen in combat but was NOT the risk for IBS. It was food poisoning during combat. IBS is a post-infection event changing the gut microbiome. link.springer.com/article/10.100…

2/2 4. Transcriptomics shows the damaging effects of #SIBO, #IMO and mostly #ISO (hydrogen sulfide) on the small intestine 5. Lactulose is better than glucose for three gas breath test 6. Elemental diet is an effective option to treat #SIBO and #IMO