Dr Aditya Gudheniya

Why is Venereal Disease Research Laboratory (VDRL) test positive in patients with antiphospholipid syndrome? The VDRL test measures antibodies against negatively charged phospholipids, such as cardiolipin. Antibodies recognising negatively charged phospholipids can cause…

Sunday feels like a joke when you’re a resident with a seminar coming up

Lactase, the enzyme that digests milk sugar (lactose), is present in the small intestine during infancy but decreases with age in most adults, this is called acquired lactase deficiency and is the most common cause of lactose intolerance. Around 70% of adults globally, including…

India has one of the world’s highest Helicobacter pylori infection rates , estimated between 50-90%, often acquired in early childhood. In contrast, Japan’s H. pylori prevalence is around 55%. Yet, India reports a much lower incidence of gastric cancer (~4.5 per 100,000)…

Nausea and vomiting are neurophysiologically distinct phenomena. 👇 Why does ondansetron stop vomiting but not always nausea? ▪️ Vomiting is mediated by brainstem centers (area postrema, NTS) and responds well to 5-HT₃ antagonists like ondansetron. ▪️ Nausea requires intact…

Stool consistency depends on two key things: 1. The amount of water in the stool, and 2. The ability of solids (like undigested fibre and bacterial matter) to bind that water. In steatorrhea, excess fat in the stool interferes with this water-binding process. So even if the…

Acute decompensation. Non-acute decompensation. Further Decompensation. Recompensation. Pre-ACLF. ACLF. Reversal Of ACLF. Regression of cirrhosis. #MedTwitter

Ondansetron reduces postprandial urgency in IBS-D by blocking serotonin-mediated gut reflexes. #MedTwitter

Aspirin came from willow bark. But that doesn’t mean chewing willow bark is medicine. The active ingredient ‘salicin’ was isolated, purified, studied in trials, and precisely dosed for safety and effect. In herbal preparations: No standard dose No toxicity data No controlled…

You’re not “just” a medical student. You’re someone’s first listener, first comfort, first hope. Don’t underestimate what you carry. #MedTwitter

Squatting is a more physiological posture for defecation than sitting. Because : -Relaxes puborectalis → straightens rectoanal angle -Enables faster, complete evacuation -Reduces straining → protects pelvic nerves.

In chronic pancreatitis, reduction in pain over time is not a marker of clinical improvement. With progressive fibrosis, destruction of intrapancreatic nerves leads to decreased nociception a phenomenon termed “burnout.” This phase typically coincides with worsening endocrine…

Gastritis is not always about spicy food or stress. In India, H. pylori infection is rampant. Chronic infection can cause pangastritis, ulcers, even cancer. If reflux-like symptoms are persistent, test and treat for H. pylori.

During a case presentation today on cholestatic jaundice, my consultant asked me to state Courvoisier’s law. I quoted it as written in some older papers, but he interrupted me and said that a law should be quoted in exact wording. I tried to explain that the original paper was…

Minimal Hepatic Encephalopathy affects work performance, employment, and finances especially for blue-collar workers. Nearly 60% with minimal HE (Blue Collar ) are unfit to work, compared to 20% of white-collar workers as verbal intelligence is preserved in these patients.

What is Glycogenic Hepatopathy? A reversible liver injury from glycogen overload , it is seen in poorly controlled Type 1 DM. -Suspect it in: Recurrent DKA + tender hepatomegaly + ALT > AST (200–800) -Mimics: Autoimmune hepatitis, NAFLD, ischemic or drug-induced hepatitis…

Just as cluster headaches can trigger suicidal thoughts due to unbearable pain, Hyperemesis gravidarum (HG) can do the same because of relentless vomiting, dehydration, and starvation. ➤ 15–27% report suicidal ideation ➤ Over 50% consider abortion ➤ 10–20% terminate wanted…

High-dose oral vitamin B12 (≥1000 mcg/day) is effective even in cases of malabsorption, including pernicious anemia, post-gastrectomy states, and celiac disease, due to passive diffusion mechanisms that bypass intrinsic factor. Parenteral B12 (IM injections) is not routinely…

Heartbroken . No words are enough. Prayers and strength to the families. May the departed rest in peace. #AI171