Corey

Update on the floating 3D printed proteins I was hoping to have a store to ship 3D printed proteins to customers but the print farm cannot print the structures reliably so the models need more work Going to put that project on hold to build other stuff!

World's first floating 3D printed protein I chose GFP because of it's amazing beta barrel structure and how we can make it glow with the LED like it does in nature Really happy with how this turned out, I'm going to keep this spinning 24/7 on my desk kit from @BambulabGlobal

🏆How we made an EGFR binder 8X better than the benchmark in 30 mins (while sipping kombucha) — and won the @adaptyvbio competition

Super cool protein engineering tournament, just registered!

Ginkgo cloud labs when? I’m curious what’s holding this back? Costs, market size? Seems like the infra is already there PPI affinity measurements and simple plate based enzymatic assays seem like low hanging fruit I’d love to see the AWS of biotech

There goes the rest of my day…

Time to build some sweet 0 calorie de novo protein binders 🍭 While sweet proteins already exist, see @ooblifoods, with de novo design we could make sweeter, smaller, and more stable versions

Who’s building this app?

sci-hub.se/10.1126/scienc… For those who want to read about dino protein sequences but are stuck behind the paywall

This is awesome, engineered natural competence in the world’s fastest growing bug, speeding up cloning and expression cycles, eventually will be accessible through Seb’s online store. Sign me up! @ATinyGreenCell any plans to make it inducible?

Here’s the LOV2 domain from Oat, with bound FMN ligand This 3D print was more challenging due to the supports and the balance is off for floating so it needs improvement Still looks cool and good to know the bound ligand is possible Setting up a shop for GFP and Nanoluc

Here’s Nanoluc, the world’s brightest luciferase enzyme Send me PDB ID’s of your favorite protein and I’ll try to 3D print a few more! Let me know if you’d be interested in buying a floating 3D printed protein kit, if there's enough interest I’ll work out how I can sell these

V1 of the floating protein structure I need to modify it so the magnet is held in place better, but I’m happy how it came out without extra supports I decided to go with GFP because it’s an iconic protein and also the levitating magnet has a light so we can make it glow.

Progress towards floating proteins: Just received the levitation kit, now time to 3D print some protein structures Tried it out with one of my kids toys, and the kids were blown away!

Just submitted my greenhouse gas removal grant proposal to @HomeworldBio to engineer and evolve E. coli into the worlds first synthetic methanotroph Excited to see other projects proposals and ideas submitted!

I just ordered this magnetic levitation kit, going to attempt to make floating 3d printed protein structures. NIH has a really cool resource of ready to print structures - 3d.nih.gov/discover?sort=… ca.store.bambulab.com/products/magne…

Excited to test this

This pretty much settles it: we're entering the era of low-cost, on-demand binders for everything Excited to see what people build now that "inject a llama with some junk and bleed it a month later" is no longer the cutting-edge tech nature.com/articles/s4158…

Amazing: skin uses a commensal bacteria as a vaccine and loading new proteins on the commensals makes for new topical vaccines. Congratulations @mfgrp and team!

We updated our BindCraft preprint with lots of new exciting results! We release all our binder sequences and models, include more in silico analysis, novel design targets, and present AAV retargeting to specific cell types using de novo binders! biorxiv.org/content/10.110…