Michael Fischbach
@mfgrp
Liu (Liao) Family Professor of Bioengineering, ChEM-H @Stanford.
The Weill Cancer Hub is fostering groundbreaking @UCSF–@Stanford collaborations to develop transformative cancer therapies. I’m grateful to co-lead one of the selected teams with @mfgrp to advance next-generation in vivo CAR T cell therapy!
Backed by a $100M gift from Joan and Sandy Weill, UCSF and @StanfordMed @StanfordCancer are launching Weill Cancer Hub West, a $200M initiative in team science to accelerate cancer research and improve care over the next decade. tiny.ucsf.edu/ppVRqt
I’ve been busy this week… 👀 Passed my PhD defense! Insanely grateful for @mfgrp. Truly epic scientist and human.
What an amazing story that was such a blast to collaborate on with @mfgrp lab!!! Phenomenal work led by @DjenetBousbaine and all co-authors!! Unroll this thread and be amazed 🤯👇🏾
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
A typical project for an incoming graduate student might involve 1–2 weeks of planning and 2–5 years of execution, [yet] the problem you choose will influence the impact of your work just as much as the quality of your execution. – Michael Fischbach buzzsprout.com/1744020/episod… @mfgrp
@SU2C Scientific Advisory Committee member @mfgrp published a paper in @Nature showing that immunity to a common skin bacteria involves a coordinated T and B cell response, which can be redirected against pathogens as a novel form of topical vaccination nature.com/articles/s4158…
Extremely proud to find this innovative vaccine platform from Michael Fischbach at Stanford. Imagine no more jabs! Low cost and globally deployable. thetimes.com/uk/science/art…
The skin — once thought to be a mainly passive barrier — can produce its own antibodies that fight off infections nature.com/articles/d4158…
take some time now to read this thread it explains what happens with the immune system when swabbing (no entry!) a bacteria on the head of a mouse it beautifully walks us through the years-long scientific journey and is exemplifies how our competitors are in fact our friends❤️
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
imo this is one of the most exciting lines of immunology research in recent years
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
wow 😮 🦠
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
Big leap forward in our understanding of interactions between our immune systems and microbiomes, and a promising path to new and better vaccines
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀 And did I say 👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀👀
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
Epic thread. Not just a very promising result, but also a good story of how research is done.
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from transgene expression and real-time…
This is a very important discovery and a brilliant example of engineering a resident skin bacterium to elicit powerful immune responses! This approach has the potential to lead to highly potent vaccines that can be administered as a simple skin cream. Very exciting!
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
Incredible study and great thread!
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
Biology is wild. Very cool results from a grantee, suggesting prospect for vaccines that could be administered as a topical cream.
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
Very interesting work @mfgrp team, and appreciate the clear educational thread!
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
Check out our last pub. from @mfgrp lab! We discovered that skin commensal microbes induce systemic and local B cell responses upon colonization and took advantage of this knowledge to create topical vaccines using engineered skin microbes. Please read the thread for details.
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
Beautiful work with @DjenetBousbaine @kdbauman_ @mfgrp @BelkaidLab - skin commensal colonization generates re-directable and potent antibody responses!
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55