Chen Liao
@cliao345
Incoming Assistant Professor @GeiselMed @DMS_MicroImmuno. We study microbial metabolism in human gut microbiome. @BIOENGatIL, @ustc alumni.
My lab at @GeiselMed has an open postdoc position in fungal metabolomics. We will combine isotope tracing, mass spectrometry data analysis, and mathematical modeling to understand metabolic rewiring in fungal cells. Research question depends on your interest. Please RT and apply!
Towards the #AI virtual cell, which would represent one the most extraordinary achievements in life science cell.com/cell/fulltext/… @CellCellPress @StephenQuake @czi @cziscience @_bunnech
1) Since there is a lot of confusion about the reduction of the overhead rate on NIH grants to 15% (see here: grants.nih.gov/grants/guide/n…) I'll do a little tweetorial (or X-torial?) about it.
Pls share: The BioMT Core facility at Dartmouth is hiring! Come join a great scientific community. Biochemistry Core Director: apply.interfolio.com/154316 Protein Biochemist – Research Scientist: apply.interfolio.com/161499
The PhD application deadline for the Quantitative Biomedical Sciences program at Dartmouth (geiselmed.dartmouth.edu/qbs/) is this coming Sunday (Dec 1). If you like bioinformatics, including translational or data structure research, QBS is a great addition to your application list.
⏰ There is only one month left to apply to join us in MCB at Dartmouth! Learn more about MCB and the application process here 🧬🔬: graduate.dartmouth.edu/mcb/admissions… @DartGRAD @DartmouthBCB @MsbDartmouth @DMS_MicroImmuno
Big thank you to @TrendsMicrobiol, @FlorentMorio, @NicolasPapon49 and Anais Herivaux for highlighting our recent story on undetected heteroresistance causing failure of antifungal prophylaxis. @tmhohl71 @BingZhai @cliao345 Joao Xavier nature.com/articles/s4159…
Heteroresistance: a hidden cause behind antifungal prophylaxis failure dlvr.it/TDwzFh
I trained a LLM for single cell RNAseq generation recently. Terabytes of data. Megawatts of GPU usage. Lights in houses dimmed all throughout silicon valley. In the end, it learned to predict cell type. As in, the predictions were only slightly better than the mean expression!
A CABBI #Conversion team at @UofIllinois developed a mathematical framework to explore proteome allocation in E. coli microorganisms, providing insights into quantitative microbial physiology and the design of synthetic gene networks. 📰 @ACSSynBio: pubs.acs.org/doi/10.1021/ac…
Bloodstream infections with Candida parapsilosis in allogeneic hematopoietic cell transplant recipients are associated with heteroresistance to the antifungal micafungin @tmhohl71, @DWeissLab, @BingZhai, @cliao345, @SidJaggavaraapu nature.com/articles/s4159…
Bloodstream infections with Candida parapsilosis in allogeneic hematopoietic cell transplant recipients are associated with heteroresistance to the antifungal micafungin @tmhohl71, @DWeissLab, @BingZhai, @cliao345, @SidJaggavaraapu nature.com/articles/s4159…
For good science, one person in the collaboration should have their feet on the ground (be an expert in the field) and the other person should have their head in the clouds (full of ideas from other fields).
Thank you @MSKCancerCenter and @EmoryUniversity for highlighting our most recent work on life-threatening fungal infections in patients. mskcc.org/news/msk-resea…
A new study from @MSKCancerCenter that explains why antifungal prophylaxis can fail and lead to life-threatening Candida infections in BMT patients. Huge congratulations to study team. #TransplantID @davidrandes @FungalDoc @GermHunterMD @PergamIC @LionakisLab @NatureMedicine
How could patients on antifungal prophylaxis still get infected by “susceptible” fungal strains? We try to crack this puzzle with a 5-year patient and mycobiome dataset from @MSKCancerCenter and 219 fungal genomes from three continents. 1/n nature.com/articles/s4159…
I knew nothing about fungi when I started this collaboration. Special thanks to @BingZhai and @tmhohl71 for the opportunity. @BingZhai has been a great collaborator and taught me so much. This work changed my career, laying the foundation for my K99 and future lab @GeiselMed.
This is a fantastic collaboration among groups of @tmhohl71 @DWeissLab @TheXavierLab and myself. Special thanks to Chen Liao @cliao345 for bringing his brilliant modeling to this study, thank @SidJaggavaraapu @T19R84 @yeastpi @EBabady and all collaborators across 🇺🇸 🇨🇳 🇪🇺 2/n
Thrilled to reunite the medical mycology and fungal immunology community in Ventura Beach in January 2025. Don't wait, go ahead and register, and submit your abstract. Link: grc.org/immunology-of-… Please RT.
Wow, @nature has retracted the 2020 Poore et al. cancer microbiome paper that we showed (journals.asm.org/doi/10.1128/mb…) was deeply flawed. The retraction date is tomorrow so I can't yet read the official notice, but I'll update when I can @RetractionWatch @ProfBootyPhD
Hypoxia limits C. albicans. Anaerobiosis limits growth of C. albicans. #Antibiotic disruption of anaerobiosis drives C. albicans bloom, which can be prevented w/probiotic bacteria that respire oxygen or pharmacological restoration of anaerobiosis @abaumler cell.com/cell-host-micr…