Roshni Patel
@RoshniAPatel
postdoc at USC with @DocEdge85. previously at Stanford with @jkpritch. pop gen, stat gen, complex traits, ELSI. she/they. 🏳️🌈
Excited to share the last paper from my PhD, advised by @spence_jeffrey_ and @jkpritch! We explore a new way to study selection on complex traits that circumvents some of the most troublesome limitations of GWAS biorxiv.org/content/10.110… (1/9)
Hiring Eleanor would be like hiring a -senior- postdoc. Don't pass up this opportunity to convince her to work with you!
I will present my poster Wed afternoon about single cell eQTL mapping using scalable count models. I m also looking for post doc lab. Happy to chat! 😊
I'm thrilled to share that I'll be joining the Department of Genetics at UGA as an Assistant Professor in January! @uga_genetics @universityofga
In #GENETICS, @RoshniAPatel, @spence_jeffrey_, @jkpritch, and colleagues explored the use of conditional frequency spectra to study selection on complex traits that circumvent some of the limitations of #GWAS. From our new Biobanks Series, read more: bit.ly/4gXsc1x
New paper with @smishra677 ! Maybe it will bring you some joy given all this (waves arms around). "Estimating recombination using only the allele frequency spectrum" 1/2 biorxiv.org/content/10.110…
Super excited to share my first grad school paper! It was so much fun working on this collaborative project from day one as a rotation student in the Curtis lab! Such a joy to work on with Katie, @LiseMangiante, @CrisISotomayor, @cncurtis and @caswell_jin & thanks to the lab!
The Curtis Lab’s latest study on the genomic architecture of breast cancer from the pre-invasive to metastatic setting is now out in Nature! nature.com/articles/s4158…
Have a little new piece in @NatureHumBehav: "Ethics of genomic research on occupational status" nature.com/articles/s4156…
Specificity, length, and luck: How genes are prioritized by rare and common variant association studies biorxiv.org/cgi/content/sh… #biorxiv_genomic
In a new preprint led by @TheNikhilMilind, we explored a fascinating paradox: For many traits the number of duplications or loss-of-function (LoF) mutations is correlated with phenotype. Curiously, for most traits, the AVERAGE direction of LoFs and Dups is the SAME. Why?
Course content can be found here: stanford-genethics.github.io And their publication on the course can be found here: cell.com/cell-genomics/…
was truly so much fun chatting with two of my personal role models - thanks @jpflores_31 for having us!!
In this episode, I interviewed Dr. Roshni Patel (@RoshniAPatel) & Dr. Rachel Ungar (@raungar), former students (now postdocs!) that developed the course "Introduction to Genetics, Ethics, & Society" @Stanford. I'm so lucky to learn from and know them!
For many traits there is a correlation between the number of duplications or loss-of-function (LoF) mutations someone carries, and their phenotype. Curiously, for most traits, these effects are aligned in the SAME direction. Why?
I am looking for a postdoc to work in theoretical population genetics. We focus on theory and methods for inferring demographic histories and selection using modern and ancient genomic data. Come join our amazing community in Chicago. More info here: steinrueckenlab.uchicago.edu/files/2024/11/…
NBC News projects: Angela Alsobrooks (D) wins Maryland Senate. Earlier, Lisa Blunt Rochester won her Senate race in Delaware. That means — for the first time ever — the Senate is about to have two Black women serving at the same time.
1/n New preprint alert! 🚨🧬✨ The question we asked; is the genetic architecture of a complex trait different at the extreme ends of the distribution (i.e. tails) or similar to that in the main part of the trait distribution? #ASHG2024 #ASHG24 --> check out poster 4051T! 🧵👇🏾
Stabilising selection enriches the tails of complex traits with rare alleles of large effect biorxiv.org/cgi/content/sh… #biorxiv_genetic
Heading to #ASHG24 and looking for a postdoc position? Interested in genetic epidemiology, specifically gene x environment in diverse pediatric cohorts? I'll be here all week so find me to talk about opportunities with myself and @priya4genes at @jhugeneticepi in Baltimore!
I want to try something new at #ASHG24 this year: I'm going to block some time on Friday afternoon to meet with any trainees who would be interested to chat on any topic.
And here's where it gets really interesting: rather than thinking of Pando as a single "individual", we should probably view it as a long-term evolving clonal population - similar to bacteria in @RELenski's Long Term Evolution Experiment (LTEE). 18/30
New preprint up! We sequenced hundreds of samples from across one of Earth's oldest living organisms - the Pando aspen clone - to understand how mutations accumulate and spread in long-lived clonal organisms. Our results were…surprising. 1/30