Brett Heimlich
@brettheimlich
Cardiovascular Medicine Fellow, and @VUMC_MedPSTP at @VUMC_Heart. Post doc in @AlexBickMDPhD lab. Former @VUMCMedicineres and @NIH_Fogarty fellow.
We are excited to share our work on "closing the loop" 🔄 - a framework enabling single-cell foundation models (scFMs) to learn from experimental validation and dramatically improve their predictive accuracy! (1/n)
New preprint: teaching single-cell foundation models to learn from perturbations in collaboration with @madduri & @RUNX1Research supported by @cziscience. Closing the loop identified a target for RUNX1-FPD now in Ph2 trials 🔗biorxiv.org/content/10.110… 🧵by @yash_persh👇
We are excited to share our work on "closing the loop" 🔄 - a framework enabling single-cell foundation models (scFMs) to learn from experimental validation and dramatically improve their predictive accuracy! (1/n)
This is a remarkable feat on so many levels. *Massive* congrats to @kiranmusunuru (former @Circ_Gen EiC & @skathire lab co-alum) @Sarah_Grand @AhrensNicklas & team! nejm.org/doi/full/10.10… @NEJM (coverage nytimes.com/2025/05/15/hea… @nytimes by @ginakolata)
Our latest review, spearheaded by @AmandaDoranLab, on the Bone Marrow Niche in Cardiometabolic Disease is out in @CircRes @AHA_Research @IUSMDeptMed @VUMCResearch @HHP_UH @CVimmunology @HeatherCaslin @brettheimlich @JonathanBrownMD @FerrellLabVUMC ahajournals.org/doi/10.1161/CI…
Two VUMC physician-scientists named to medical honor society news.vumc.org/2025/01/14/two… Congrats to @AlexBickMDPhD and @VUMC_MedPSTP alum @JKropski on this well-deserved honor!
Just how many diseases can you identify with a good old 12-lead #ECG? NEW @npjDigitalMed, co-led w/ @lucidtronix, @RVpacing & @xwang, we use an autoencoder to map ECG to phenome, finding associations btwn ECG & >600 conditions @broadinstitute @broad_ml4h @MGHHeartHealth LINK⬇️
Alex Reiner @fredhutch, @AlexBickMDPhD, and I are excited to share our new preprint, “Correlates and Consequences of Clonal Hematopoiesis Expansion Rate: A 15-Year Longitudinal Study of 6,986 Women” doi.org/10.1101/2025.0… 1/n
Congratulations to @statnews 2024 wunderkind @DrFlashHeart! Caitlyn has authored more than two dozen papers with our group in the past two years on #CHIP, firmly establishing it as a risk factor for kidney disease and beyond. @VUMCgenetics statnews.com/meet-the-2024-…
.@AlexBickMDPhD, a physician-scientist at Vanderbilt University Medical Center who is known for his research on the genetics of blood disorders, has been named director of the Division of Genetic Medicine. Congrats, Dr. Bick! @VUMCgenetics @VUMC_Medicine bit.ly/3TRcY53
We are excited to share our new preprint “Variance quantitative trait loci reveal gene-gene interactions which alter blood traits”! medrxiv.org/content/10.110…. Thread below 🧵 1/n
Congratulations to @alyssa_c_parker from our group on receiving the 2024 Basic Sciences Dean's Award!
🎉 Congratulations to the 2024 Basic Sciences Dean's Award winners who were recognized for their high academic and scientific achievement and for the originality, significance, and rigor of their dissertation research. 🌟🔬 Learn more 👉 medschool.vanderbilt.edu/basic-sciences…
Congratulations Dr. @taralynn_mack on a spectacular PhD defense! Your science, mentorship and leadership in the lab and across campus is an inspiration. It has been such a privilege to learn together the past 3 years. @VUMCgenetics @VUBasicSciences @VUmedicine @VUMCDiscoveries
Excited to share our paper @Laventaobare @tecla_temu @VUMC_heart @VUMC_MedPSTP @VI4Research , "Inflammation in HIV and Its Impact on Atherosclerotic Cardiovascular Disease" now published in @CircRes ahajournals.org/doi/10.1161/CI…
CHIP stands for clonal hematopoiesis of indeterminate potential. But it's no longer "indeterminate," as exemplified by this report, and needs a new abbreviation @NatureMedicine by @DrFlashHeart @AlexBickMDPhD and colleagues nature.com/articles/s4159…