Andrew Savinov
@bioSavinov
Biophysicist using single-molecule & high-throughput methods to interrogate sequence-structure-funct. K99 @MIT w/ @GeneWeiLiLab & Stan Fields; PhD: Steve Block.
Happy to announce that our paper on systematically discovering peptides to inhibit protein-protein interactions in living cells is out now @PNASNews: pnas.org/doi/10.1073/pn…. @MITBiology @ScienceMIT @HHMINews See quoted thread on the updated preprint for details:
Excited to share our updated manuscript on FragFold, the massively parallel AlphaFold-based approach we’ve developed to discover protein fragment inhibitors at scale -- w/ @SassSeabass, @keating_lab, and @GeneWeiLiLab. biorxiv.org/content/10.110… (1/n)
More functional protein fragments! Further evidence of their important roles in physiology and disease.
A new study finds that fragments of viral proteins, including SARS-CoV-2 spike peptides, can bind and either inhibit or activate human formyl peptide receptors (FPR1, FPR2, FPR3) which influences innate immune responses like neutrophil migration and NETosis. 1/
Super exciting work from @GallowayLabMIT
MIT engineers have figured out how to turn skin cells directly into neurons — skipping the stem cell stage entirely. This could fast-track therapies for spinal cord injuries, ALS, and more. news.mit.edu/2025/mit-engin…
We were thrilled to see our co-founder @Micro_Yunha speak at @BostonBacterial Meeting yesterday on a panel about how AI is reshaping biological research. Thank you to the BBM team for putting together such a thoughtful event! One clear takeaway: there’s a real sense of…
BioEmu 1.1 predicts functionally relevant conformational changes, including large-scale domain motions and local unfolding events + an increased success rate in predicting the formation of “cryptic” binding pockets.
How Harvard Medical School and industry scientists revolutionized cancer treatment
In the nucleus, many intrinsically disordered proteins (IDPs) form condensates. What IDP sequence features drive this behavior? We developed CondenSeq, a high-throughput method to measure nuclear condensate formation & applied it to ~14000 IDPs to find out rdcu.be/eq975
Congratulations to Barbara Imperiali, the Class of 1922 Professor of Chemistry and Biology, who has been elected as a Fellow of the Royal Society, the United Kingdom’s national academy of sciences. chemistry.mit.edu/chemistry-news…
Daša Lipovšek expanding today's discussion to include miniprotein radioconjugates, which link target-binding proteins with radioisotopes that can kill cells or be detected with imaging devices. This facilitates greater targeting and functionality. @kochinstitute #KIsymposium
Delighted to bring gene circuits into a wide array of primary cells where they can be used for safe, effective gene therapies. 🧵 (1/n) Tremendous work by lead author @kaseyslove to dig into the details of these systems and figure out how to get these to work well! Original…
Loss of gene expression can compromise cellular fitness. In the case of such haploinsufficiency, replacement of the gene supplementation could rescue cell health. But what if you need a very precise dosage? Try ComMAND! 🧵 (1/n) Link: doi.org/10.1101/2024.0…
Whitehead Institute and Harvard researchers have developed Perturb-Multi, a powerful new approach that simultaneously measures how genetic changes, such as turning off individual genes, affect both gene expression and cell structure in intact tissue.
Congratulations to Elçin Ünal on her promotion to MCB Professor of Genetics, Genomics, Evolution, and Development! 👏🎉 mcb.berkeley.edu/news-and-event…
We are excited to share our new preprint, “An improved model for prediction of de novo designed proteins with diverse geometries”. (1/9) biorxiv.org/content/10.110…
quick reminder to join us at @MIT tonight for a great #RNA talk by @silvirouskin!
Protein isn't the only amazing macromolecule that folds into 3D shapes - come see @silvirouskin in Room 181, Building 68 @MIT on Wednesday, June 11th at 7pm EDT to learn more about #RNA structure design and modeling! "RNA Function, Design, and Modeling" bpdmc.org
Excited to be at the @BostonBacteria Meeting this year! I'll be a panelist at the AI in biology breakout session on Tuesday 6/10 after lunch, in Hall A -- together with @Micro_Yunha and M.S. Suryateja Jammalamadaka. Come join us for what should be a great discussion!
Excited to unveil Boltz-2, our new model capable not only of predicting structures but also binding affinities! Boltz-2 is the first AI model to approach the performance of FEP simulations while being more than 1000x faster! All open-sourced under MIT license! A thread… 🤗🚀
Congratulations to the @gilliardgroup members graduating from @MIT! Proud of you and what you have accomplished!
In a medical milestone, a customized base editor was developed, characterized in human and mouse cells, tested in mice, studied for safety in non-human primates, cleared by @US_FDA for clinical trial use, manufactured as a complex with an LNP, and dosed into a baby with a severe,…
A baby named KJ, who was born with a rare genetic disorder – CPS1 deficiency – is healed thanks to doctors at the @ChildrensPhila who administered the world’s first personalized gene-editing treatment. The research team used base editing, a gene-editing method invented by HHMI…