Álvaro Andreu-Bernabeu

Extended periods of loneliness in youth elevates schizophrenia spectrum disorder (SSD) odds. Check out our new BJPsych study: 🧵👇 | The British Journal of Psychiatry | Cambridge Core - bit.ly/3G1odnD

Congrats to my colleagues at RGC (Sheila Gaynor, @Tim_A_Thornton and team) on their new publication in @NatureGenet on value of exome vs genome sequencing in gene discovery. nature.com/articles/s4158… The message is clear: exome sequencing is more cost-effective than genome…

Inarguably the most important human genetics paper of the year, and a landmark moment in the history of neurodevelopmental disorder (NDD) genetics. Mutations in RNU4-2, encoding a small nuclear RNA (snRNA) are among the most frequent genetic causes of NDD, explaining up to 0.4%…

"Los periodos prolongados de soledad en la juventud aumentan la probabilidad de padecer Trastornos del espectro de la Esquizofrenia" Genial trabajo de @andreu_bernabeu y @gonzalez_penas @PsiqInfantil

Integrating CAL with schizophrenia polygenic scores boosts positive predictive value from ~2.8% (genetics alone) to 17% overall—and up to 22.5% in females.

Examining the sensitivity for environmental influences by conducting a GWAS on differences between identical twins - very clever design! Out now in @NatureHumBehav: nature.com/articles/s4156…

In every civilization, people end up sorted into levels of socio-economic status (SES). We explore the history, present, and future of scientific research on the complicated relationship between SES and DNA in @NatureHumBehav 💰🧬🎓 Link: rdcu.be/efacK Thread below 👇🏽

The truth is that the scientific process is horribly inefficient and wasteful. But the solution is NOT cutting funds and it’s NOT top down guidance of what should be studied. Instead, we should revolutionize how we publish and improve peer review.

Anatomy of Moncrieff's Anti-Medication Playbook @joannamoncrieff has a carefully honed 3-step strategy of attacking psychiatry, which she has used with remarkable power against the medical establishment. Step 1: Identify a narrow, technical assertion pertaining to the…

Are mental disorders extreme manifestations of continuous traits or genetically distinct entities? We present Genomic Taxometric Analysis of Continuous and Case-Control data (GTACCC) for evaluating genetic continuity of traits across the severity spectrum. Tweetorial coming soon.

Este intercambio (junto con los trabajos que citan) entre dos de las grandes figuras de la genética poblacional es un curso avanzado para cualquiera interesado

I wrote a bit about the two very interesting studies of siblings/families from last week. Tan et al. family GWAS (medrxiv.org/content/10.110…) and Sidorenko et al. sibling heritability estimates (nature.com/articles/s4158…). A few surprising findings summarized here: 🧵

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I wrote about the knowns and unknowns around polygenic embryo selection, expanding on a previous post about genetic prediction of IQ. A short 🧵:

Finally, we now know exactly which region and cell types in the brain are mediating the actions of GLP1R agonists. As many suspected, it's not the hypothalamus where the magic happens. It's brain stem, particularly a region called dorsal vagal complex (DVC). Two GLP1R…