Alex Strudwick Young
@AlexTISYoung
Asst. Prof. @ UCLA Human Genetics. Statistical geneticist. Mendelian inheritance is the most important natural experiment. Formerly Oxford and deCODE.
See our No-Spin report on the Baby’s First Years RCT, studying the effects of providing unconditional cash transfers to low-income, new mothers in the US. In brief: This high-quality RCT found no impact on any of the study’s primary child development outcomes at 4y follow-up.🧵
Short Sleep Variants Do Not Replicate In March Kristjan Moore from deCODE genetics emailed me urging me to stop working on short sleep. I read paper in question since Jan, but was still hoping/coping that maybe NPSR1 variant (not included in the paper) would replicate.
On IMO P6 (without going into too much detail about our setup), the model "knew" it didn't have a correct solution. The model knowing when it didn't know was one of the early signs of life that made us excited about the underlying research direction!
One piece of info that seems important to me in terms of forecasting usefulness of new AI models for mathematics: did the gold-medal-winning models, which did not solve IMO problem 6, submit incorrect answers for it? 🧵
With AIs getting IMO gold, my mind went back to a conversation I had with Augie Kong in June. Augie thought that being a successful scientist in his mold was more about high-level conceptualization of problems and seeing things that others don't than about raw mathematical…
With Augustine Kong - my postdoc supervisor, inventor of long range phasing, and originator of 'genetic nurture', among many other scientific and statistical contributions - at Le Manoir aux Quat’Saisons.
New preprint! We unveil the profound connection between the Ancestral Recombination Graph and Linear Mixed Models. Guess what? Random effects are merely a consequence of mutations running on a fixed genealogy. biorxiv.org/content/10.110…
Eight healthy babies born after IVF using mitochondrial DNA from third person #mitochondrialdonation nejm.org/doi/full/10.10…
We're investigating how much of the FrontierMath gain is attributable to web search. Two problems went from never being solved before to >80% success rate among the 16 parallel evals. For those two, it was clearly the web access that made the difference.
Don't have access yet but intrigued by the improved math benchmarks. Curious how much is an improved underlying model capabilities in math and how much is improved ability to look stuff up online.
More fear mongering. Is there any documented case of a regular innocent person having suffered anything whatsoever by doing 23andMe or indeed any sort of consumer genetic test? washingtonpost.com/technology/202…
Wow! LCT doesn’t affect your height today, but in the past lactose persistence would make you taller. Makes me think of those “got milk?” ads. Amazing paper! Congrats Samantha Cox and @mathiesoniain !!!
Effects of ancestry, agriculture, and lactase persistence on the stature of prehistoric Europeans biorxiv.org/content/10.110…
New preprint with Guy Sella on the question: what is polygenicity? biorxiv.org/content/10.110…
3,800 years old intact warrior Kurgan found in Azerbaijan. The interred warrior (estimated to have been over 2 meters (6'6) tall,) was buried in a semi-flexed position. Its probably associated with the Trialeti Vanadzor culture. popular-archaeology.com/article/a-3800…
Good idea. They should sequence the parents too.
I missed this news, but it's really exciting: Parents in Florida will now be able to get a free whole-genome sequence for their newborns.
I missed this news, but it's really exciting: Parents in Florida will now be able to get a free whole-genome sequence for their newborns.
Cancer is back. My latest scan (a PET-CT) revealed a 1cm lesion in a lymph node of my liver. Unfortunately, it is not in a favorable position for surgical resection or standard ablation because of its proximity to an artery. They're starting me on infusions of irinotecan and…
In March last year, at the age of 35, I was diagnosed with advanced stage III rectal cancer with a metastasis in my liver. This was a shock: I had no family history, and none of the doctors suspected it. In fact, I'd had a negative occult blood test when I went to ER with severe…
As someone who's lived in the UK, EU, and US, it's pretty obvious that most Americans have a very poor mental model of Europe and vice versa. Much online Europe vs America discourse is therefore very dumb.
Without saying anything, show me how long you’ve been on the internet
Without saying anything, show me how long you’ve been on the internet
A more complete understanding of human genetics starts with accurate, high-quality reference genomes. HPRC is building a reference that reflects the breadth of human genetic variation, supporting better prediction, diagnosis, and treatment. Learn more: humanpangenome.org/samples/
Proteomics on fossils > 20 million years old. Absolutely incredible!!!
nature.com/articles/s4158…
Staff scientist position (computational): I am looking for a computational scientist to join my genomics lab at Stanford. They should have an outstanding skillset in ML/statistical methods for genomic applications, postdoc experience and a strong publication record. #sciencejobs