Andre Faure @ajfaure.bsky.social

🎲 Our paper on the genetics, energetics, and allostery in proteins with randomized cores and surfaces is out today @ScienceMagazine! 🧬 By charting a protein’s sequence universe, we could rationalize which versions were kept through evolution – and why many stable ones were not.

“Every government should be there,” says @FranceskAlbs. On 15 July, South Africa and Colombia will convene states from around the world to coordinate measures to halt the Gaza genocide. Listen to Francesca Albanese, and learn more about the conference: thehaguegroup.org

Alzheimer’s disease 🧠starts with a molecular domino effect - but what triggers the first piece to fall? In our new study we cracked open the black box of early protein aggregation, and the findings could reshape how we fight neurodegeneration. 🧵👇 science.org/doi/10.1126/sc…

The European Commission has just made it clear that the rigid constraints they had placed on public finance were totally artificial. They have now lifted them to enable massive military production. The EC could have done the same thing to achieve rapid decarbonization and…

Applications for our Bootcamp for Scientist Founders program BSF13 close on Jan 27 👀 We started BSF @wilbe_science to enable the most effective transition from scientist to founder. 12 cohorts, 250 BSF Fellows, 4 years in and some incredible companies in the making, here's…

Introducing Human Domainome v1, the largest and most comprehensive library of human protein variants to date, which maps the effects of +500K mutations across 522 domains. The study by @BenLehner and Toni Beltran @mutatoni is out in @Nature. ✍️ Illustration by @QueraltTolosa

Thrilled to announce Boltz-1, the first open-source and commercially available model to achieve AlphaFold3-level accuracy on biomolecular structure prediction! An exciting collaboration with @jeremyWohlwend, @pas_saro and an amazing team at MIT and Genesis Therapeutics. A thread!

CLIMATE PROTESTORS NEED TO STOP BLOCKING ROADS!!

what’s most frustrating about Trump is that we’re wasting our last few good years before full climate collapse dealing with the dumbest Hitler of all time

This unconscionable law against #UNRWA is an outright attack on the rights of Palestinian refugees. It is clearly designed to make it impossible for the agency to operate in the Occupied Palestinian Territory by forcing the closure of the UNRWA headquarters in East Jerusalem and…

🧪 Are you passionate about molecular cloning? 🧬 Are you interested in applying ingenious methods for generating mutant libraries? 💊 Are you excited to join an exceptional team of scientists committed to revolutionising drug discovery? If so, here is a new job opportunity 👇

The genetic architecture of protein interaction affinity and specificity nature.com/articles/s4146… by @Guillaume_Diss @AlexBendel_ + @aj4re

Our paper on deep mutagenesis of JUN’s interaction with the 54 human bZIP is now out in @NatureComms rdcu.be/dWXmn Great work from @AlexBendel_, with @aj4re and @BenLehner Thread in quoted post 👇

With more variations of a small protein than atoms in the universe, how can scientists possibly predict mutation effects? 🌌 With simple maths, finds new research This could speed up our understanding of diseases and drug design sanger.ac.uk/news_item/prot…

Leaving no one behind is how to unlock lenacapavir’s full potential, fulfil Gilead’s promise, protect a generation from HIV and bring forward the end of the AIDS pandemic. #endAIDSby2030 @katlay @Guardian @MohgaKamalYanni @UNAIDS @PeoplesMeds theguardian.com/global-develop…

The genetic architecture of protein stability by @aj4re @ainamartiaranda @cristonah @ToniBeltran13 @JoernSchmiedel nature.com/articles/s4158… @CRGenomica @sangerinstitute @ALLOXbio

A much improved version of this, today out in @NatureGenet ! with @BenLehner and @FranSupek nature.com/articles/s4158…

“The price of anything is the amount of life you exchange for it” — Henry David Thoreau, Walden