Ignasi Toledano
@IgnasiToledano
Collaborative PhD with @BenLehner and @GenomeDataLab; playing around with tons of mutations, RNA and translation
A much improved version of this, today out in @NatureGenet ! with @BenLehner and @FranSupek nature.com/articles/s4158…
Time to share my PhD work where we quantified the translational readthrough of thousands of pathogenic stop codons and trained predictive models to predict drug-induced readthrough of any stop codon. With the priceless guidance from @FranSupek +@BenLehner! biorxiv.org/content/10.110…
At @ALLOXbio we now have 3 computational positions available! 📌Structural Bioinformatics Scientist 👉 tinyurl.com/3rs46j4t 📌Platform Bioinformatician 👉 tinyurl.com/nyvazbke 📌Computational Chemist 👉 tinyurl.com/5n6vpem3 Apply or repost to help us spread the word 🙏
🔥PhD student & postdoc opportunity @GenomeDataLab! Are you keen on: - driving cutting-edge science @ interface of #AI and cancer #genomics? - working in a dynamic & supportive environment of @UCPH_BRIC? - joining the U of Copenhagen, top-3 ranked uni in EU? Apply below👇
The genetic architecture of protein stability by @aj4re @ainamartiaranda @cristonah @ToniBeltran13 @JoernSchmiedel nature.com/articles/s4158… @CRGenomica @sangerinstitute @ALLOXbio
We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. biorxiv.org/content/10.110…
Investigadors catalans desenvolupen un algoritme "detectiu" per predir els millors fàrmacs contra trastorns greus, com malalties degeneratives i alguns tipus de càncer ccma.cat/324/desenvolup…
(1/2) The #BISTIgnite Programme is open for applications! An opportunity for #BISTCommunity researchers & postdocs to Ignite new interdisciplinary research collaborations No preliminary results are needed in the seed phase, just an idea + a team bist.eu/research/ignit…
Thrilled to announce we just got funded by @novonordiskfond Research Leader program!! We will explore the mechanisms behind islet cell maturation using human pluripotent stem cells. Recruiting PostDocs and PhD students really soon, get in touch ;) @STEMMProgram @helsinkiuni
Introducing the Domainome... Site saturation mutagenesis of 500 human protein domains reveals the contribution of protein destabilization to genetic disease by @ToniBeltran13 @CRGenomica @sangerinstitute @BGI_Genomics biorxiv.org/content/10.110…
Our randomisation of hydrophobic protein cores is out @bioRxiv! With Gesa Voigt, @aj4re and @BenLehner we learned that pervasive allostery constrains evolution beyond stability and that this is indeed simple to model despite limited epistasis we identify biorxiv.org/content/10.110…
I’m super happy to finally share what I have been up to the last few years at the @BenLehner lab in Barcelona! We made lots of double mutants on the kinase domain of Src to study allosteric communication.
The allosteric landscape of the Src kinase. Amazing work from @ToniBeltran13 with @aj4re biorxiv.org/content/10.110… @CRGenomica @sangerinstitute
Honored to be among the recipients of the NWO Open Competition M1 grant! We will develop tools to improve our understanding of TCR-antigen interactions, using high-throughput screening & AI. Stay tuned for a postdoc vacancy to join this exciting project! nwo.nl/en/news/ninete…
Just out in Nature Communications. Great finish to Kotcha's thesis work and extremely productive collaboration with Bedwell lab at UAB! We define cis-acting sequences regulating translation termination & accurately predict readthrough efficiency of multiple CFTR nonsense alleles.
Excited to share my PhD journey exploring NMD efficiency's variability across tumors, tissues and individuals. Link: biorxiv.org/content/10.110… A big thank you to @FranSupek and the awesome lab @GenomeDataLab at @IRBBarcelona 1/7🧵👇
What if we could build complete maps of allosteric sites for entire proteins? Now we can. Super excited to see this heroic effort by @WengChenchun @BenLehner @AlbertIltirda finally published. nature.com/articles/s4158…
🇩🇰My lab at @UCPH_BRIC Uni of Copenhagen, Denmark is recruiting 💻 #bioinformatics and ⚗ wet-lab #postdocs and 🧑🔬#research assistants Cancer evolution, genome instability, artificial intelligence for DNA analysis. #ERC & NNF projects 👇Positions listed below. Please RT! (RX?)
Extremely simple biophysical models do surprisingly good genetic prediction in sequence spaces >10^10, suggesting that vogue deep learning models may be unnecessarily complex. New work + scientific debut for Aina Martí-Aranda w/ @cristonah & @BenLehner biorxiv.org/content/10.110…
Excited to finally share some of my PhD work on quantifying the effects of indel mutations on protein stability and function using deep mutational scanning. From sunny @CRGenomica together with @ToniBeltran13 and guidance from @BenLehner biorxiv.org/content/10.110…
New chapter in our ongoing RNA Review Series: @JavierFCaceres1 et al discuss #mRNA quality control mechanisms including non-stop and no-go mRNA decay pathways and the nonsense-mediated mRNA decay pathway Translation-coupled mRNA quality control mechanisms embopress.org/doi/full/10.15…