Guillaume Diss
@Guillaume_Diss
Group Leader @FMIscience, Basel
In a new study published in @NatureComms, researchers led by @Guillaume_Diss have provided key insights into how protein interactions are governed and how mutations influence cellular functions—work that might help advance personalized medicine. fmi.ch/news-events/ar…
The genetic architecture of protein interaction affinity and specificity nature.com/articles/s4146… by @Guillaume_Diss @AlexBendel_ + @aj4re
Our paper on deep mutagenesis of JUN’s interaction with the 54 human bZIP is now out in @NatureComms rdcu.be/dWXmn Great work from @AlexBendel_, with @aj4re and @BenLehner Thread in quoted post 👇
First paper for @AlexBendel_, together with @aj4re and @BenLehner. We measured how all mutations in JUN’s leucine zipper perturb it’s interaction with all 54 human bZIPs. biorxiv.org/cgi/content/sh… (1/4)
We’re looking for a postdoc with a strong background in AI, biophysics, modeling or related. Please forward to potential candidates and RT 🙏 More details below 👇
Postdoc Opportunity👉Join @Guillaume_Diss' group to study how the sequence of a protein determines its function! In this role, you'll leverage large datasets to train generative models to predict protein-protein interaction affinity from sequence. Apply at fmi.ch/education-care…
We will be hiring 👇 - apply if you are interested in understanding mechanisms of developmental timing using genomics, genetics, molecular biology, quantitative time lapse imaging, modelling, ...
Still a few week left to apply to our PhD and MD-PhD programs! Join us if you want to do cutting-edge research in the life sciences while enjoying a vibrant, international and supportive environment 👇🏽
Really proud of my first PhD student @AlexBendel_ for winning the award for the best thesis of 2023 at @FMIscience!!!
The Ed Fischer Prize is awarded to @AlexBendel_ for investigating how proteins interact with each other, using advanced methods to study millions of these interactions. The committee was impressed by the research complexity and Bendel's strong leadership in the project.
The Ed Fischer Prize is awarded to @AlexBendel_ for investigating how proteins interact with each other, using advanced methods to study millions of these interactions. The committee was impressed by the research complexity and Bendel's strong leadership in the project.
Our paper on functional discovery of protein degradation and stabilization effectors with proteome-scale induced proximity screens is out in its final version! 1/ nature.com/articles/s4158… rdcu.be/dBUju
📢We're now accepting applications for our #PhD and #MDPhD programs! 🧬Join us in Basel, Europe's top hub for the #lifesciences, and unleash your potential in a vibrant, international and supportive environment 📅Apply by May 1 at bit.ly/FMIspring2024 #AcademicTwitter
🔥Cell biology meets structuromics🔥 1000s of proteins assemble co-translationally but we don't know why🤷♂️ @Robb_Mallik found it’s all about protein 🧩structure🧩, with implications for #gene_expression, #proteostasis, #evolution & #mRNAlocalization 🧵👇 biorxiv.org/content/10.110…
New preprint from @aj4re @CRGenomica @sangerinstitute MoCHI: neural networks to fit interpretable models and quantify energies, energetic couplings, epistasis and allostery from deep mutational scanning data biorxiv.org/content/10.110…
Junior Group Leader position in Genome Biology @CRGenomica. pls RT. Very open call. Quantitative and AI approaches particularly encouraged. recruitment.crg.eu/content/jobs/p…
Extremely simple biophysical models do surprisingly good genetic prediction in sequence spaces >10^10, suggesting that vogue deep learning models may be unnecessarily complex. New work + scientific debut for Aina Martí-Aranda w/ @cristonah & @BenLehner biorxiv.org/content/10.110…
The genetic architecture of protein interaction affinity and specificity @AlexBendel_ + @Guillaume_Diss + @aj4re quantified how mutations alter binding of a protein to all its possible interaction partners to understand specificity encoding biorxiv.org/content/10.110…
Start the engines!
We are thrilled to launch our new programme, Generative and Synthetic Genomics! 🎉 Led by @BenLehner, we’ll use big #data & #AI to understand & predict the effects of mutations, and engineer biological systems 🧬 With support from @wellcometrust sanger.ac.uk/news_item/pred…
Our latest paper exploring how MYC-MAX and CLOCK-BMAL1 engage with chromatinized E-boxes is out @Nature: rdcu.be/df8qh. We thank all the collaborators for their valuable contributions! @jsmenet @partchlab @Beatfierz @SchubelerLab @johannes_zuber, Becker lab & Liu lab