Alex Federation
@afederation
Co-founder, CEO of Talus Bio illuminating the regulome | controlling the genome | drugging the 'undruggable' #proteomics, #teammassspec, #chembio
I just ran the first n=1 dynamic regulome experiment. On myself. A 72-hour fast where we tracked all 4,000+ components of the genome regulatory 'software' to see how they respond And over 30% changed, most never mentioned in fasting literature Why does this matter? Well, why…
Founders: at the start, you don’t need to convince the world. You just need to convince a small group of people who care deeply.
See you in Seattle!
We're coming to Stanford, Berkeley, UW, Caltech to help more scientists start companies.
Another gem from @hodgeshc and team β-catenin isn’t just a Wnt effector, here it’s acting as a molecular adapter to link BAF remodelers to other key TFs Happens through structured IDR contacts This is probably just scratching the surface to untangle these complex…
Excited to share our new Molecular Cell paper! We show that β-catenin is an adaptor that links canonical BAF (cBAF) with binding partners via IDR-domain interactions. (1/7) cell.com/molecular-cell…
NIH won’t fund grants with ideas “substantially developed by AI” USPTO won’t recognize AI as an inventor But we’re building autonomous systems to train foundation models of genome regulation What happens when the models discover new biology/drugs without any human input?
I can’t get this line out of my head since reading it at the end of the abstract for this paper: “Sleep, like aging, may be an inescapable consequence of aerobic metabolism.” nature.com/articles/s4158…
Latest regulome self-experiment aborted. 7 miles into a marathon Wife’s water broke More to come soon
Me in my 20s: Biotech should empower more people in their 20s. Me in my 40s: Biotech should empower more people in their 20s.
How high-resolution do we need/want aging clocks to be? Hours? Days? Months? We're starting to explore this by measuring the transcription factors that orchestrate epigenetic machinery. These change on the order of hours-days
Two take-aways from David Furman's talk during day 1 of @LongevityDublin : (1) Trajectories of change in "aging clocks" are likely more informative than absolute age-estimates during normative aging (2) Microgravity accelerates many phenotypes of aging - perhaps accelerates…
Genes set ~7 % of our lifespan ceiling. Calico’s 400 M-person pedigree study found that once you correct for who marries whom, DNA’s share of longevity drops to single digits. The other 93 % rides on how we interact with the world.
Do most transcription factors already have an off-switch? Map of degrons across every human TF from Fia Larsen, @CagiadaMatteo, @_amelie_rocks + team Could be new handles to design precise gene circuits and leveraged for the 'undruggable' drug hunt. biorxiv.org/content/10.110…