Cohesin
@Xieeee4
I am a scientist studying how epigenome regulates gene expression | https://xieeeee.github.io/
How does heart failure rewire gene regulation? 🔍 Excited to share our single-cell, multimodal epigenomic resource on human heart failure🫀: doi.org/10.1101/2025.0….
New preprint! We solve a mystery you didn't know existed. Mitotic cells lack new transcription but require ongoing translation. Interphase mRNA half life is only 2-4 hrs. So how do cells arrest in mitosis for hours without depleting their transcriptomes? biorxiv.org/content/10.110…
From Silver to Gold🥇 Our advanced version of Gemini Deep Think has achieved the gold-medal standard at the 2025 International Mathematical Olympiad. It perfectly solved 5/6 problems in natural language with no expert intervention and that too within 4.5 hours!
An advanced version of Gemini with Deep Think has officially achieved gold medal-level performance at the International Mathematical Olympiad. 🥇 It solved 5️⃣ out of 6️⃣ exceptionally difficult problems, involving algebra, combinatorics, geometry and number theory. Here’s how 🧵
A method for synthesis and assembly of megabase-scale DNA, along with an approach to deliver it into mouse embryos, offers a valuable tool for investigating de novo epigenetic regulation. nature.com/articles/s4159…
I'm super excited to share that I will be joining the Department of Biology at @Stanford as an Assistant Professor in October 2025! I’ll also be a member of the Stanford Stem Cell Institute @CellStanford. Incredibly grateful to be starting my dream job!🧠🧬🖥️
Our scMicro-C paper is out in @NatureGenet! Huge thanks to the reviewers for their valuable insights, to @XieSunney for unwavering support, and to fantastic collaborators @JiankunZhang21 & @tanlongzhi. Thrilled to share this work!
Very excited to share our work on high-resolution single-cell Micro-C, which is on bioRxiv now. Here we reveal that cohesin-mediated loop extrusion participates in transcription with kilobase-resolution single-cell 3D structures. biorxiv.org/content/10.110…
I’m relocating to NYC in early July 2025! Excited to catch up with old and new friends and chat about science. Let’s connect! ☕️
Beautiful works🤩🤩
If heterochromatin is really a liquid-like condensate, why is it not spherical? We investigated whether mechanical interactions between a condensate and a fiber network can explain the variety of morphologies seen in phase-separated nuclear compartments. biorxiv.org/content/10.110…
1/14 On behalf of the amazing team in @JswLab, we’re excited to share PEtracer (biorxiv.org/content/10.110…) a prime editing-based evolving lineage recorder compatible with both scRNA-seq and high-resolution imaging readouts in intact tissue. By applying PEtracer in a syngeneic mouse…
Targeting DNA damage in ageing: towards supercharging DNA repair nature.com/articles/s4157… This new Review discusses approaches to pharmacologically mitigate the adverse effects of DNA damage to prevent mutation-driven cancers and mitigate age-related degenerative diseases
We are looking for talented postdocs/visiting students to join our team @MITdeptofBE and @kochinstitute to innovate spatial multi-omics technologies, map clinical samples, and integrate AI/ML models to advance next-generation cancer immunotherapy. Please help to spread!!
Introducing Neuropixels Ultra, a new probe with >10x site density: an implantable voltage camera capturing complete planar images of neurons' electrical fields in vivo! ⬆️ spike sorting yield, ⬆️ detection of small fields and ⬆️ cell type identification.🧵 biorxiv.org/content/10.110…
This level of disrespect towards international talent is not really new. I vividly remember how humiliating my student visa appointment interview was many years ago. Now it's just being said out loud by the VP of the USA.
Vance is so good: "The American Space Program, the first program to put a human being on the moon, was built by American citizens. This idea that American citizens don't have the talent to do great things, that you have to import a foreign class of servants, I just reject that."
The peer-reviewed version of expansion in situ genome sequencing is now out in Science! The news is bittersweet – when we first revealed this last September, I never guessed it would be my final paper in academia, but a lot has changed. A few parting thoughts:
insane😡
Breaking News: The Trump administration halted Harvard’s ability to enroll international students, a major escalation in its battle with the school. nyti.ms/3SLG7gW
A triumph of perseverance from twitterless Tom Weber, Christine Biben and the team, our in vivo barcoding "LoxCode mouse" used to resolve epiblast fate to fetal organs is finally published in @CellCellPress and available to import through @jacksonlab sciencedirect.com/science/articl…
Today in @Nature, we report a spatial single-cell atlas of human cortical development, revealing surprisingly early specification of human cortical layers and areas. We built an interactive browser to explore the spatial data: walshlab.org/research/corte… Paper link below👇
We are looking for a research assistant to join the lab and work on spatial genomics. Please help spread the word—thanks! careersearch.stanford.edu/jobs/life-scie…
The preprint of our liver paper is up! We profiled 86 human livers with single cell sequencing assays for gene expression, chromatin accessibility, histone modification, and chromatin contact to understand liver gene regulation and fatty liver disease. medrxiv.org/content/10.110…
Two new studies examining cell type-specific genomic changes in (i) liver in MASLD and (ii) heart chambers in heart failure from our group and many great collaborators @WestonElison @Xieeee4 @ChangLei0821 @CEpigenomics medrxiv.org/content/10.110…, medrxiv.org/content/10.110…