Eider Valle-Encinas (She/her)
@ValleEncinasE
Scientist at HUB Organoids. Organoids, stem cells and in vitro systems. Open Science💛Views are my own
To celebrate my last week in Cardiff, my birthday and the week of @TalksWnt, my second modest contribution to the Wnt and liver fields is alredy available in @BioRxiv biorxiv.org/content/10.110…
An interesting article tackling how we can bring #organoids to industry. Thanks for sharing!
Our opinion piece: "Bridging the academia-to-industry gap: organ-on-a-chip platforms for safety and toxicology assessment" is now out in @TrendsinPharma. Full paper: bit.ly/3w5R4wb Ty @shrikezhang @66mh & Yi-chin for the opportunity and guidance!
We engineer peptides to sense targeted enzyme activity in cancer tissue! Published in @NatureComms: ✅ nanoscale + noninvasive ✅ high-fidelity cancer monitoring ✅ multi-scale resolution sensing from single cell 🦠 - to tissue 🫁 - to whole organism🧍 👉nature.com/articles/s4146…
Online Now: The therapeutic window of antibody drug conjugates: A dogma in need of revision dlvr.it/SbM3Ks
I am a 2022 Schmidt Science Fellow! Fortunate to join an incredible community of interdisciplinary young scientists, congratulations to all the 29 new fellows around the world! Thanks @MIT @jababi @peko23 for the nomination! And to @SchmidtFutures @SchmidtFellows @rhodestrust!
Tonight we celebrated the start of the @SchmidtFellows Five Year Anniversary and welcomed our fifth cohort - we are now 113 Fellows from 30 nationalities supported by a strong community of interdisciplinary science friends.
Excited to assist the virtual @embl symposium Microbial Infections and Cancer on behalf of #HUBOrganoids
Lymphoid follicles on a chip 🤯 wyss.harvard.edu/news/the-immun… via @wyssinstitute
The only thing we love more than a cool organoid paper is a cool organoid paper with an awesome video! 📹
📢Out in Cell Reports📢 The Competition is on!!! Active elimination of intestinal cells drives oncogenic growth in #organoids Congratulations @SasSuijk, Ana Krotenberg Garcia and co for this beautiful paper! 🔬 cell.com/cell-reports/f…
Proud to share this @NatureGenet publication. By integrating live-cell imaging of tumor organoid outgrowth and single cell #sequencing we could reconstruct evolving tumor cell karyotypes. Congrats to the team! doi.org/10.1038/s41588… #Organoids #cancergenomics #bioinformatics
Featuring parasitic worms inside organoids (mini-guts!) Great models for studying specific livestock host-pathogen interactions in vitro - in line with 3Rs principles and making livestock biology accessible to researchers without large animal facilities.
The development of ovine gastric and intestinal organoids for studying ruminant host-pathogen interactions biorxiv.org/cgi/content/sh… #biorxiv_micrbio
You've gotta be kidney-ing me! 😂 Seriously, though, a huge round of kudos to everyone who contributed!
Check our new research progress @NatureComms. Congrats to Zipeng and Biao. Many thanks to Drs. McMahon, Hallows, Pastor-Soler and Grubbs, and the support from @USCStemCell @ukrocharity @keckkidneys. We are now one step closer to a synthetic kidney✌️. disq.us/t/3y58ir6
Korea Institute of Toxicology scientists present a quantitative method to directly quantify the physiological changes in complex 3D #intestinal organoid structures based on impedance spectroscopy. 👩🔬👨🔬 bit.ly/3cReZZA
Sometimes science takes a wee while, but very pleased to introduce our new paper, stke.sciencemag.org/content/14/688… a collaboration between our lab @mrc_hgu and the Forbes lab @crm_edinburgh investigating how Notch regulates #stemcell behaviour in the liver. Here’s a science 🧵
Great project, great lab. What more could you want?
📌 We are looking for a Postdoctoral Scientist to join @owen_sansom lab and support investigations into cell competition and cell-cell communication in the intestinal stem cell niche in the context of colorectal cancer. 📅Apply by 9th July More detail: beatson.gla.ac.uk/Postdoctoral-F…
Elated to share our work highlighting the role of tissue-resident macrophages in early lung cancer. Just out @Nature @SinaiImmunol @HFSP @AACR #macrophages #Immunotherapy. nature.com/articles/s4158… A tweetorial! 1/5
Have you ever wondered exactly what happens when Cas9 creates a double-strand break? We're excited to share Repair-seq, an approach for screening how thousands of genetic perturbations change the mutations that cells make when they repair DNA damage. biorxiv.org/content/10.110…
This just dropped 👇Couldn't be happier that it is out. Thanks @ohyilmaz and all the wonderful authors. High-fat diet-activated fatty acid oxidation mediates intestinal stemness and tumorigenicity cell.com/cell-reports/f…
Thrilled that our review on in vitro gut-microbe interaction modelling with #organoids and #organ-on-a-#chip is just out in @cellhostmicrobe (cell.com/cell-host-micr…). Once again great to work with my partner in (detecting microbial) crime @Cayetanopm and @HansClevers on this!
Promotion committees still want to see papers accepted (no Biorxiv). Even with good reviews, everything is taking months longer to complete due to restrictions & shortages. Added complications of being a junior PI during COVID.
We have learned so much from conditional mouse knockouts, but single Cre drivers have limitations. Now in @CellStemCell: a suite of new Dre recombinase drivers opens up new possibilities in genetic targeting 🧬 sciencedirect.com/science/articl…
Our work is out in @nature! We reconstructed ancient microbial genomes from paleofeces and found 61 previously undescribed species. Massive thanks to @adkostic for believing in me to take on this challenge. Thanks to co-authors, referees, friends & family. nature.com/articles/s4158…