The Human Pancreas Analysis Program - HPAP

In the new series by Diabetes Care highlighting 75 years of NIH NIDDK research, the groundbreaking TEDDY Study is featured. This pioneering study is helping better understand the environmental determinants of Type 1 Diabetes in youth and includes UFDI faculty investigators — Dr.…

HPAP now has CODEX data available from 148 donors on PANC-DB! Check it out here: hpap.pmacs.upenn.edu/explore/downlo…

Please check out our @HIRN_CC webinar “Introduction to the New Islet Function Portal on PANC-DB" here: youtube.com/watch?v=UdcauF…

New research published in Nature Communications with UFDI collaborators Dr. Melanie Shapiro, Dr. Mark Atkinson, and Dr. Todd Brusko reveals immune cell disruptions in pancreatic lymphatic tissues may precede Type 1 Diabetes onset—offering key insights into early detection and…

🚨New work from our lab with important clinical implications. Thanks to our collaborators in ⁦@TheHPAP⁩. Spatial transcriptomics from pancreas and local draining lymph node tissue reveals a lymphotoxin-β signature in human type 1 diabetes | bioRxiv biorxiv.org/content/10.110…

Two new, NIH funded postdoc positions are available! (1) Somatic mutations as primary causes of autoimmune disease and (2) Epigenetic drivers of diabetes in humans - please send CV and names of references to: [email protected]

The new interactive HPAP perifusion data dashboard is now live on PANC-DB! Check it out here: hpap.pmacs.upenn.edu/explore/perifu…

HPAP recently added 49 new single-cell multiome data sets to PANC-DB! Access the data here: hpap.pmacs.upenn.edu

The January/February Issue of the HIRN newsletter is available online. Information about a recent @TheHPAP publication, @PanKbase launch, meetings/webinars and job postings! View at: conta.cc/4idBgjj

Please check out the new preprint from HPAP: Single-cell multiome analysis supports α-to-β transdifferentiation in human pancreas biorxiv.org/content/10.110…

*Job Alert* The Integrative Immunology and Cell Design Laboratory led by Dr. Mo Haj Dezfulian at the University of Pennsylvania is recruiting postdoctoral fellows! For more information: med.upenn.edu/apps/my/index.…

Looking forward to a great PANC-DB demo at the @HIRN_CC meeting!

G6PC2 controls glucagon secretion by defining the set point for glucose in pancreatic α cells ft. @13ah1_V, Eric Waite @CatherineLeeMay Elisabetta Manduchi, @bvoight28 @Michelle_YY_Lee Mark Tigue, Nicholas Manuto & @KlausKaestner (@PennIDOM/ @PennGenetics) science.org/doi/10.1126/sc…

This Thursday 12/12 come join us for Carmella Evans-Molina @cevansmo on ER regulation of beta cell function!

Yi and Eizirik re‐analyzed scRNA‐seq data from @TheHPAP database to further investigate the β‐cell stress signatures (e.g, inflammation, autophagy, apoptosis, and ER stress) potentially present in individuals living with #type1diabetes and #type2diabetes. onlinelibrary.wiley.com/doi/10.1111/17…

Don't wait - register now for the 2025 HIRN Annual Meeting to learn & discuss the state of the diabetes research & future direction of T1D research. Preliminary agenda posted on the website. Register at: niddk.nih.gov/news/meetings-…… All welcome to attend! Please share

We welcome investigators to submit their abstracts to present orally or at our poster session during the 17th Annual Scientific Meeting! Deadline is November 18th at 5PM: npod.org/abstracts

AnnoSpat annotates cell types & quantifies cellular arrangements from spatial proteomics ft. Aanchal Mongia, Noah Burget, @YeqiaoZhou, @bfariabi (@PennPathLabMed/ @PennEpiInst), Yue Wang, @KlausKaestner & @golnaz_v (@PennGenetics) & Ali Naji (@PennIDOM) tinyurl.com/3ffj3rey

The latest HIRN Newsletter is available online! Information about our upcoming meeting, new publications, meetings and funding opportunities! View at: conta.cc/3Xi2D2

A review of progress in cell replacement therapies for #T1D #diabetes #stemcells #islets @NatureRevEndo nature.com/articles/s4157…