Perrimon Lab
@PerrimonLab
Dr. Norbert Perrimon's lab at Harvard Medical School researches functional genomics, cell circuitry, and tissue homeostasis in Drosophila melanogaster.
New paper: Multi-omic mapping of Drosophila protein secretomes reveals tissue-specific origins and inter-organ trafficking Bosch et al. doi: doi.org/10.1101/2025.0…
Qadiri, e (2025) FlyPhoneDB2: A Computational framework for analyzing cell-cell communication in Drosophila scRNA-seq data integrating AlphaFold-Multimer predictions. Comput Struct Biotechnol J. 27:2814-2822. doi: 10.1016/j.csbj.2025.06.032.
New paper: Song, Y., Hu, Y., Dow, J., Perrimon, N. and Papatheodorou, I. (2025) ScGOclust: leveraging gene ontology to find functionally analogous cell types between distant species. Bioinformatics. 4:i571-i579. doi: 10.1093/bioinformatics/btaf195. PMID: 40662793
New Paper: Viswanatha , Entwisle, Hu, Kim, Reap, Butnaru, Qadiri, Mohr, Perrimon. Higher resolution pooled genome-wide CRISPR knockout screening in Drosophila cells using integration and anti-CRISPR (IntAC) Nature Communications doi.org/10.1038/s41467…
New paper: Cholinergic Signaling Modulates Intestinal Pathophysiology in a Drosophila Model of Cystic Fibrosis Elizabeth Lane, Afroditi Petsakou, Ying Liu, Weihang Chen, Mujeeb Qadiri, Yanhui Hu, Norbert Perrimon doi: doi.org/10.1101/2025.0…
New paper: Ben Ewen-Campen, Weihang Chen, Sudhir Gopal Tattikota, Ying Liu, Yanhui Hu, Norbert PerrimonThe Drosophila proventriculus lacks stem cells but compensates for age-related cell loss via endoreplication-mediated cell growth doi: doi.org/10.1101/2025.0…
Protein folding stress transcriptionally reprograms muscle metabolism Jacob Paiano, Mujeeb Qadiri, Suhasini Sharma, Yanhui Hu, Norbert Perrimon doi: doi.org/10.1101/2025.0…
Kang et al. (2025) NF-κB-mediated developmental delay extends lifespan in Drosophila PNAS. 122(19):e2420811122. doi: 10.1073/pnas.2420811122.
Xiao, G. et al. (2025). Intratumor HIF-1a modulates production of a cachectic ligand to cause host wasting. Cell Insight. doi: 10.1016/j.cellin.2025.100247. PMID: 40336592
TF2TG: an online resource mining the potential gene targets of transcription factors in Drosophila. Hu Y, Rodiger J, Liu Y, Gao C, Liu Y, Qadiri M, Veal A, Bulyk ML, Perrimon N. Genetics. 2025 doi: 10.1093/genetics/iyaf082. PMID: 40314147
Hepatic gluconeogenesis and PDK3 upregulation drive cancer cachexia in flies and mice. Liu, Dantas, Ferrer, Miao, Qadiri, Liu, Comjean , Davidson, Perrier, Ahmed, Hu, Goncalves, Janowitz, Perrimon. Nat Metab. 2025 doi: 10.1038/s42255-025-01265-2. PMID: 40275022
Lipid metabolism of hepatocyte-like cells supports intestinal tumor growth by promoting tracheogenesis Kerui Huang, Ting Miao, Ezequiel Dantas, Myeonghoon Han, Yanhui Hu, Keven Wang, Jack Sanford, Marcus Goncalves, Norbert Perrimon doi: doi.org/10.1101/2025.0…
Simonian, Meyer, Guo, Sha, Wohlschlegel, Droujinine, Perrimon, McMahon (2025) Sex and depot specific adipocyte proteome profiling in vivo via intracellular proximity labeling. Comprehensive Physiology. 15(2):e70007. doi: 10.1002/cph4.70007. PMID: 40181252
TF2TG: an online resource mining the potential gene targets of transcription factors in Drosophila. Hu, Rodiger, Liu, Gao, Liu, Qadiri, Veal, Bulyk, Perrimon biorxiv.org/content/10.110…
The epigenetic factor Zrf1 regulates intestinal stem cell proliferation during midgut regeneration Joshua Shin Shun Li, Liu, Kim, Qadiri, Xu, Xia, Binari, Asara, Hu, Perrimon bioRxiv 2025.01.16.633419; doi: doi.org/10.1101/2025.0…
events.cancer.gov/dcb/beyond-mam… Virtual seminar series that the US National Cancer Institute (NCI) is holding on non-mammalian models of cancer.
Cell-death induced immune response and coagulopathy promote cachexia in Drosophila. Ankita Singh, Yanhui Hu, Raphael Fragoso Lopes, Liz Lane, Hilina Woldemichael, Charles Xu, Namrata D. Udeshi, Steven A. Carr, Norbert Perrimon doi: doi.org/10.1101/2025.0…
