Tal Nuriel, PhD

🚨 In this paper in @NatureCommuniations, we find that Down syndrome #Alzheimer exhibits unique pathological features compared with sporadic late-onset and autosomal dominant AD with important implications for treatment strategies. nature.com/articles/s4146…

X certainly has its place in the social media ecosystem, and I appreciate being able to read and engage with opinions so radically different than my own. But also, I’m so happy that this place is no longer the only “digital town square” that people have available to them.

Very excited to share the results of this collaborative work in young adults with spina bifida. APOE4 carriers showed smaller left amygdala volumes —suggesting early neurodegeneration risk. Can MRI help identify vulnerable SB subgroups? #APOE4 #MRI doi.org/10.1002/cns3.7…

Sitting for hours daily shrinks your brain, even if you exercise. New 7-year study (n=404): → Faster hippocampal atrophy → Worse memory performance → Slower processing speed 87% met exercise guidelines but STILL declined.

Got a research grant. 🤓 My lab at Weizmann Institute now has more PhD student and postdoctoral researcher positions available - send me an email if you are interested (there are no geographical restrictions and virtually no visa formalities).

Serious question. Are there any innovative ways to increase the paylines at NIH aside from increasing funding levels or decreasing the number of applicants? It’s such a wasteful process to keep submitting grants that only have a 7-17% chance of being awarded.

Deliriously excited to share our new Neuron Perspective on transformative neuropathology—a roadmap to accelerate brain health discoveries through broader support of brain banks with tech-enabled, team-science approaches to tissue. 🧠 Perspective article: cell.com/neuron/fulltex……

Largest-ever tau-PET studies confirm ties between tangles and cognitive decline. ApoE4 carriers and women get tangles earliest. @_michael_scholl @AlexisMoscoso9 @amsterdamumc ow.ly/k8O750WqRix

Grant terminations have grabbed the headlines and have seen legal action, but even more damaging to the US research enterprise has been the massive decrease in research grants issued by federal agencies NIH: -57% in the number of awards and -63% in value compared to FY24

I like this idea, but I’m not seeing what the cap amount is? Also, could you please send me our NOA so that we can do our research??

My lab’s 5-year NIH R01 grant, awarded to study gene therapy for hearing loss, was abruptly terminated. I want to share how this action has been incredibly harmful and disruptive, not just to my lab, but to the scientific process itself. 1/15

In this new research article, our colleague, Dr. Sean J. Miller and our lab show that COVID virus can induce Alzheimer’s disease beta-amyloid further confirming the role of the amyloid beta protein as an antimicrobial peptide. pubmed.ncbi.nlm.nih.gov/40614201/

I love this thread with people getting angry at Grok for fact checking a post, and Grok just continuing to respond to each person with more valid data.

On the bright side, at least now I won’t keep getting confused about why everyone is talking about the blood brain barrier.

Same here. And most smaller lab like mine don't have sufficient discretionary funds to run the lab more than a few months. This is going to end up with mass layoffs in academia. I know it has already started many places from new applicants I get.

I’m in the same situation. Many of us are. A non-competitive renewal should be a smooth process. It’s previously unheard of for the paperwork to be so slow that we face such a funding crisis. This is an intentional breaking of the system, with a goal of undermining research.

Yes same here. We were expecting non-competing continuations on Feb 1, March 1, and April 1, and none of them came. Attempts to ask anyone go into a black hole, generally no reply. In one case they said "we are awaiting new instructions". I think it's a ploy to run the clock out…

NIH is slow to send funds for non-competing renewals. This is disrupting research in many labs, including mine. I was expecting payment for one NINDS grant 2 months ago, but I'm still waiting. I don't understand exactly why this is happening. It'd be impossible for us to…

Is it your first time (or even your 10th time) giving a talk at a big conference like #AAIC25? Timing is important for your confidence, and out of respect for the audiovisual team, your co-chairs, and hybrid audience. 10-minute presentation tips: Sketch out 10 slides on paper…

I agree! But also, the NIH should actually fund the grants that have already been awarded, so that we can perform the science that will then be freely accessible to the public.