Rezwan Siddiquee
@RezwanSidd
PhD Candidate in Synthetic Biology #Proteins #seekRNA @Sydney_Uni. Other half of @TaylorSzyszka https://scholar.google.com/citations?hl=en&user=nZ8TDHcAAAAJ
Out now in @NatureComms! We've discovered a programmable #seekRNA that can mediate the insertion of any cargo DNA into any target DNA sequence it seeks! This brings forth a new era of gene editing technology. nature.com/articles/s4146…
Congratulations to A/Prof @YuHengLau for receiving a 2024 Career Development Fellowship from @cancerNSW for his project ‘Developing targeted therapies for gliomas by peptide-assisted fragment optimisation.’! Read more: tinyurl.com/5n9x9896
I am once again pitching my romantic comedy: - two academics start dating - discover they are each other's terrible reviewer - hijinks ensue Working title: Love is Double-Blind
🧬Happy Transposon Day! 🎉Each year on the 16th of June we commemorate the birthdate of the founder of transposable element research, Barbara McClintock (1902-1992). Check out quotes from editors and popular content on our #TransposonDay2025 page 👉mobilednajournal.biomedcentral.com/transposonday2…
Employing engineered split inteins to replace the internal regions of target proteins in a single reaction. science.org/doi/10.1126/sc… #NBThighlight
Oh my goodness, I feel like I have made it as a scientist! @paperperday just retweeted our paper (accepted to @angew_chem like 2 days ago!) Thank you so much for boosting our discovery! ❤️☺️🧪
High-fidelity in vitro packaging of diverse synthetic cargo into encapsulin protein cages "Fluorescent dyes, proteins and cytotoxic drug molecules can all be selectively packaged via a peptide-mediated targeting process." onlinelibrary.wiley.com/doi/10.1002/an…
We are hiring 2 chemistry postdocs in the lab of Dr Yu Heng Lau! One synthetic chemist/med chem and one chemical biologist to contribute to our drug discovery pipeline. Details below:
We're hiring!🚨Our lab @SydneyChemistry is looking for two new #chempostdoc for our drug discovery program: 1) Synthetic/Med Chem (small molecule hit-to-lead)🧪 usyd.wd3.myworkdayjobs.com/en-US/USYD_EXT… 2) Chemical Biology (peptide inhibitors)🦠 usyd.wd3.myworkdayjobs.com/en-US/USYD_EXT… Pls spread the word!🙏
In 2000, a physicist made bacteria blink. He did so by stitching together individual pieces of DNA to build a "genetic circuit," called the repressilator. We recently published an interactive article explaining how the repressilator works, and how one can tune its dynamics. 🧵
Excited to share our review on applications of cell free expression towards natural product research. Done in collaboration with @sjmoore505, @NigelJMouncey, and Doug Mitchell pubs.rsc.org/en/Content/Art…
Protein power couple and Centre members from our @Sydney_Uni node @taylorszyszka and @RezwanSidd have been selected to be part of Raising the Bar! 👏👏👏 This unique outreach initiative features 20 academics visiting 10 bars across Sydney to deliver talks about their research,…
Banayes
"the non-browning bananas [..] are yet to be given a name" >>> what shall we call them? theguardian.com/science/2025/m…
Here we go. Next next generation of long read sequencing technology.
Sequencing by Expansion (SBX) — a novel, high-throughput single-molecule sequencing technology biorxiv.org/content/10.110…
Thanks to JAMS for the chance to speak about seekRNA technology! It was a great turnout! A great place for microbiology talks in Sydney!
Rezwan is on the seek for precision! Discovering a programmable 'seekRNA' that guides site-specific #DNAintegration 🧬 #RNA
We have PhD scholarships @SydneyChemistry available to work on a range of drug discovery and chemical biology projects in my lab, applications close Feb 21 Please let any potentially interested candidates know! sydney.edu.au/scholarships/d…
Yup. Best way to get stuff done nowadays. Design large experiments that test multiple possible hypotheses at once. Then rigorous data analysis.
First we had hypothesis-driven research. But our measurement techniques have become so high-throughput that investigating one hypothesis at a time seems poorly suited to the task. So then we had hypothesis-free research. But without knowing the hypothesis, you can never be sure…
Had such a wonderful time at #Coesb2024! Got to meet like minded synthetic biologists and learn about their successes and challenges. And huge thanks to @ARC_CoESB for an award for Outreach Excellence!
Mesmerising stuff! Holliday junction in action! Part of the hall of fame of Australian Science.
youtube.com/watch?v=Xe-83t… Incredible to watch. Got so much more respect now for the yeast cells that dutifullyintegrate the random stuff we design for them to put into their genome by homologous recombination.
Progress on open-source T7 expression vector. Work done by @Cammiebacter and Sahana tinyurl.com/4nx396rx. thanks to @AusBiofoundry for hosting and funding the work (and paying my salary haha). @ARC_CoESB meeting. Wollongong, 2024
Arrived at the Centre of Excellence in Synthetic Biology 2024 conference with Lau Lab! Ready to learn about some super cool science! Check out the amazing view from our room!
It seems easy to make fun of basic science – for example why would you want to study bacterial immune systems? But then you would have to admit that that’s exactly what led to the discovery of using CRISPR as an insanely good technology for genome engineering.
For those yet to seek bluer skies, check out our latest preprint on encapsulin protein cages! We can now assemble them beautifully in vitro, without all the ugly defects you get from using acid/base or denaturants. This lets us put any synthetic cargo into these cages.
🚨New preprint alert! What if you could put *anything* inside of a protein cage? Our new in vitro encapsulin assembly system is easy to use and enables the packaging of any synthetic or biological cargo. @SydneyChemistry biorxiv.org/content/10.110…