Nacho Molina 🇪🇺

🚨 New method alert! We developed HiddenFoot, a physics-inspired approach to decode single-molecule footprinting data and infer TF, nucleosome, and RNA Pol II binding profiles on individual DNA molecules. One molecule at a time! biorxiv.org/content/10.110…

Carrying on with Session 4 on #EMBLSingleMolecule Day 3 🤓💪🏼 ➡️ 'Decoding Gene Regulation at the Single-Molecule Level through Biophysical Modeling of DNA Footprinting Data' 🎙️ Nacho Molina – Institute of Genetics and Molecular and Cellular Biology, France

Just in case you missed this and it’s something that might interest you. #SingleMoleculeBiology, #Chromatin, #Transcription, #TF, #Nucleosome, #PolII, #Biophysics, #MachineLearning, #ComputationalBiology 👇

Happy to see published on @cddpress the result of an @AIRC_it funded study, coordinated with the tireless Alessandra Agresti and led by Federica Colombo on the role of NF-κB in multiple myeloma (MM), and its interaction with stromal cells (MSCs) nature.com/articles/s4141…🧵

After a massive team effort leaded by the incomparable @NicolaFestuccia I am really happy to share our freshly published @ScienceMagazine ms where we elevate Nr5a2 to the top of gene regulation in the morula. 🔥🔥🔥 Take a look at Nicola's description 👇! science.org/doi/10.1126/sc…

Excited to share the latest story from the @arnaud_kr lab @embl ! Together with @ChristineMoene we used Single Molecule Footprinting to reveal that RNA Pol II occupancy occurs at surprisingly low-frequency at mammalian promoters! Thread below (⬇️) 1/11

Hey, interested in discovering the molecular mechanisms behind our puzzling observations on gene-specific RNA buffering? We need you. Apply now! 👇#PostdocPosition #RNAbiology #scRNAseq @longchrom @molina_lab

A heads up to all post-docs - the Genome Biology dept @EMBL is recruiting - independent group leader (PI) position. Outstanding colleagues, students, world-leading core facilities in a very supportive, collaborative and family environment, #jobs. Ad will be posted in next days

Indeed, looking forward to this collaboration with you @molina_lab! @epflSV @cziscience

I am very happy that @cziscience has selected our research project!

Deep learning advancements change how we address challenges & bottlenecks in #SingleCell biology. See how researchers are transforming what's possible using existing data to understand health + disease with cutting edge computational approaches bit.ly/3y7EB1X

Come do your postdoc in beautiful Strasbourg @IGBMC! Collaborative project in #RNA biology between our lab and @molina_lab. Details below, please RT!

Thrilled to share the culmination of 4 years of #Fiberseq research enabling the accurate quantification of chromatin accessibility across the 6 Gbp diploid human genome with single-molecule and single-nucleotide precision. See thread for the main findings biorxiv.org/content/10.110…

Psst! An updated version of our paper is up biorxiv.org/content/10.110… 🤫We added perturbation of the ATAC coactivator, and we still find RNA buffering! Thanks to all who commented on the original version and🤞as we wait for journal peer reviews

Big congratulations to all laureates 🥳and amazing news for @IGBMC with two winners 🤩

📢 How can we identify cell lineages from any scRNA-seq dataset ? Check our paper: nature.com/articles/s4146…. Very proud of massive amount of beautiful work by @AlmutEisele, A. Dormann + fantastic collaboration with @MTarbier and @pelechanolab. A 🧵

Have you ever wondered what bacteria dream of as they sleep? Do you like quantitative approaches to single cell behavior? Time-lapse microscopy and microfluidics? Like to analyze your own data? Come join our lab!