Moritz Mall

What keeps cancer cells in check—and can we tame hem? In 2 collaborative preprints, we trace glioblastoma cell transitions in space and decode what regulates their plasticity 🧠👇 📍 Spatial & multi-omic atlas: biorxiv.org/content/10.110… 📍 Regulatory logic: biorxiv.org/content/10.110…

Diet/microbes place the gut epithelium as a nexus for evolutionary change. With @TheSpenceLab @genomeCraig, we use #organoids to explore how evolution prepared the developing human intestine for exposure to the environment. @ScienceMagazine #evodevo 🧵1/11 science.org/doi/10.1126/sc…

Great line of speakers in 12th International Heidelberg Symposium on Stem Cells and Cancer. #SCC2025 Register to meet the top experts in stem cells and cancer fields. More Info: stem-cells-cancer.de Abstract Deadline: 15 July 2025 Registration Deadline: 1 August 2025

Don't miss the Keynote Lecture by Prof. Andrew Wei from the Peter MacCallum Cancer Center at the 12th International Heidelberg Symposium on Stem Cells and Cancer. #SCC2025 Abstract Deadline: 15 July 2025 Registration Deadline: 1 August 2025 More Info: stem-cells-cancer.de

Registration still open! 🚨 Come and join us in the 12th International Heidelberg Symposium on Stem Cells and Cancer. Abstract Deadline: 15 July 2025 Registration Deadline: 1 August 2025 More Info: stem-cells-cancer.de

Don't miss the Keynote Lecture by Prof. Elaine Fuchs from the Rockefeller University at the 12th International Heidelberg Symposium on Stem Cells and Cancer. #SCC2025 Abstract Deadline: 15 July 2025 Registration Deadline: 1 August 2025 More Info: stem-cells-cancer.de

Job alert: Join us for a postdoc in AI in genetics at @EMBL Heidelberg! Great collaboration with @Adrian Cortes @GSK, aiming to develop new tools to elucidate genetic effects using population-scale cohorts and single-cell readouts. Please share! embl.wd103.myworkdayjobs.com/de-DE/EMBL/det…

Don't miss Keynote Lecture by Prof. Scott Armstrong from the Dana-Farber Cancer Institute at the 12th International Heidelberg Symposium on Stem Cells and Cancer. #SCC2025 Abstract Deadline: 15 July 2025 Registration Deadline: 1 August 2025 More Info: stem-cells-cancer.de

König Frederik X. von Dänemark überreichte gestern dem Neurologen Frank Winkler (DKFZ, @UniHeidelberg & @uniklinik_hd) den #brainprize 🏅für bahnbrechende Arbeiten zu Interaktionen des Nervensystems mit Krebstumoren.👏Winkler teilt sich den Preis mit Michelle Monje (@Stanford).

Andreas Meyer-Lindenberg, Chair of the Selection Committee, on awarding the 2025 Brain Prize: “For their groundbreaking contributions to our understanding of how neural mechanisms influence brain tumour biology—an entirely new field at the interface of neuroscience and oncology.”

Brain Prize winner Frank Winkler, Prof. of Neuro-Oncology at Heidelberg University, is delivering his Brain Prize Lecture: “Neural influences on adult brain tumors: from bench to bedside” His groundbreaking research reveals how neurons drive brain tumour progression. #BrainPrize

Integrated Organoid Atlas benchmarks new protocols, even more impressive as a Highly Variable Cohort for comparison against perturbation and disease models: nature.com/articles/s4158… Lead by @_xuquan @HalleLennard Collaboration with @fabian_theis @TreutleinLab @IHB_Research

Maarten van den Hoogenhof found a specific way to improve cardiac function in RBM20 cardiomyopathy. CAMK2 inhibition might become the first tailored therapy for a Dilated Cardiomyopathy (after mavacamten for Hypertrophic Cardiomyopathy): biorxiv.org/content/10.110…

The Single-cell Analytics Innovation Lab @MSKCancerCenter is looking for ML-oriented computational biologists. Join our team based in NYC to work on cutting-edge single-cell & spatial transcriptomics methods in collaboration with leading research labs. bit.ly/4lTEr2t

Der Deutsche Preis für #Krebspräventionsforschung, gestiftet von der Manfred Lautenschläger-Stiftung, geht in diesem Jahr an Ute Mons vom DKFZ und Carolin Schneider von der @UniklinikAachen. Herzlichen Glückwunsch! 👏 ➡️t1p.de/10zwp

Sehr verdiente Preisträger - herzlichen Glückwunsch! Tolle und ausgesprochen wichtige Forschung um die Krebsprävention weiter voranzubringen!

Brain Prize winner @michelle_monje , Professor of Pediatric Neuro-Oncology at Stanford University, is giving her Brain Prize Lecture “The Neuroscience of Brain Cancer” at the University of Copenhagen. She is a leading voice in bridging neuroscience and oncology. #BrainCancer

Today is #EndangeredSpeciesDay! Dr. @SebastianDiecke's team is using iPSCs and #organoids to study and potentially rescue the highly endangered Sumatran rhinoceros. 🦏 Learn more in this episode from 2024: bit.ly/3FkQyox

There are many implications & LOTS of detail in the preprints (e.g. mesenchymal cancer states is really a gliosis/hypoxia response & GB tumour subtypes are likely confounded) bit.ly/4mkrWgs bit.ly/3FbI6Ic

How does tumour heterogeneity arise? How can we predict cancer cell plasticity? In 2 studies, we trace #glioblastoma heterogeneity to a spatial cancer cell trajectory w. atlassing bit.ly/4mkrWgs & predict plasticity w. snRNA/ATAC+deep learning bit.ly/3FbI6Ic 🧵

🧠 Excited to share my main PhD project! We mapped the regulatory rules governing Glioblastoma plasticity using single-cell multi-omics and deep learning. This work is part of a two-paper series with @bayraktar_lab , @OliverStegle and @MoritzMall groups. Preprint at end🧵👇