REVIVED

There was no difference in the primary outcome at a median of 3.4 years, despite a high event rate in both arms.

🚨@REVIVED_BCIS2 scar analysis🫀 ➡️Scar volume & pattern highly associated with death and arrhythmia ➡️Scar assessment should be routine, particularly in those at borderline risk Out now @JACCJournals CVI🔗 jacc.org/doi/10.1016/j.… 📺Watch our summary👇 youtu.be/-eMrPRPToM0

What better way to launch our @YouTube channel youtube.com/@ukheartresear… than with a brilliant summary of the SERIAL trial by @mattlkw! youtu.be/xqCdxL-pUiQ?fe…

Cardiac Cycle 2017 was our first ride to raise funds to fight heart disease - 750km of coastal Sri Lanka for littlehearts.lk and @TheBHF with @DrPeterOKane @MassivelyMike and other friends. Cardiac Cycle 2025 on 15 Jun is for @TheBHF. Thank you for your generous support

Our IPD analysis of @REVIVED_BCIS2 and STICH is out in print today! Did PCI fail to match CABG, or did medical therapy move the goalposts? Exciting implications for @BCIS4Trial, which will complete the circle. doi.org/10.1093/eurhea…

Exciting that @CHIP_BCIS3 is now in the follow-up phase! The question of elective perc LV unloading to improve patient outcomes in high-risk PCI remains as pertinent now as when this RCT started in 2021. doi.org/10.1161/CIRCIN… Whatever the result, it’ll be worth the wait⏳

Survival better with current medical+ device therapy than STICH-era MT (+/- CABG) if LVEF<35%! ➡️ are lessons from all RCTs with a OMT control arm time-limited? ➡️ is PCI better than CABG (or vice versa)? These two trials can’t answer this. Await STICH3 trials @BCIS4Trial

📢 Exciting milestone! Guy’s and St Thomas’ NHS Foundation Trust has now randomised its 1st and 2nd participants, bringing us to 3 randomisations study-wide! 🎉 Huge thanks to the St Thomas' Hospital team for their hard work and commitment to research! @divaka_perera #BCIS4 #GSTT

‼️Ischaemia does not predict prognosis or response to PCI 📣patients enrolled in @REVIVED_BCIS2 had LVEF<35% extensive ischaemia and scar++ Paper by @hollymorgs @achir76 @divaka_perera et al out in @ehj_ed @ESC_Journals today @TheBHF @NIHRresearch doi.org/10.1093/eurhea…

Still more evidence that ischaemia doesn’t identify stable CAD patients who benefit from revascularisation: #ISCHEMIA trial and now @REVIVED_BCIS2 ❓do plaque events relate to total atheroma burden more than critical lesions ❓is arrhythmia driven by scar more than ischaemia

Does ischaemia predict clinical outcomes and response to PCI? 📣 breaking data from REVIVED in @EHJ_ed today 🚨 Patients had extensive ischaemia (mean 31% of LV) and scar (mean 18% of LV) 🚨 Ischaemic burden did NOT predict outcomes, or response to PCI academic.oup.com/eurheartj/arti…

Deep dive into completeness of revascularisation in REVIVED, ISCHEMIA and other trials @OPCILive by @divaka_perera @JWMoses @djc795 @ziadalinyc and @PaulSap9. 🎬 opci.live/opci-lives/rev… 📖 @JACCJournals bit.ly/44JRcV0 @kingscardio @NIHRresearch @BCIS_uk

Fascinating talks using pooled data from REVIVED (R) + STICH (S) ➡️ R patients had higher baseline surgical risk ➡️ No difference in tx effect in either trial by surgical risk ➡️ S-OMT arm had worse outcomes than R-OMT ➡️ R-OMT arm had better outcomes than S-CABG! #ESCCongress

How do we reconcile STICH and REVIVED? Would CABG offer survival benefit with contemporary medical therapy? ➡️ Answers at late breaking science session #ESCCongress2024 this morning! Results from the first pooled individual patient level analyses from these two RCTs

Ischemia analysis of REVIVED #ESCCongress 💜 approx 20% of LV scarred 30% ischemic on CMR 🏥 very high rates of death or aborted sudden death 📈 amount of ischemia not associated with risk of events 📈 no benefit of PCI whether ischemia extensive or mild/moderate

Fantastic today that 2 landmark RCTs our centre @UHD_NHS recruited patients for impacted ESC guidelines to direct future care: @OctoberTrial pushing IC imaging toward 1A @REVIVED_BCIS2 shifting PCI in ICM down to 2bB Great CI leadership @NielsRHolm & @divaka_perera #researchwin🏆

ESC guidelines for PCI in severe LV impairment changed from 2a LoE C (should be done in most patients, based on consensus) to 2b LoE B (may be done in selected patients, based on randomised data).#ESCCongress 🙏🏽@REVIVED_BCIS2 investigators for providing the supporting evidence

Join us this Friday 30th at the #ESCCongress for the final piece of the REVIVED puzzle! 🧩 ➡️ How ischaemic were the patients enrolled in REVIVED? ➡️ Did ischaemic burden identify patients most likely to benefit from PCI? 12:15pm @ Science Box 4!

We have to challenge dogma and firmly held views with data. REVIVED surprised us all. Severe disease. Extensive revasc. Struggling to find benefit for patients. More trials underway..@JJheart_doc @hvanspall @divaka_perera @elmir1omerovic @mbmcentegart @roxy143hearts