Marco Pignatelli
@Pignatelli_Lab
PI at @WUSTLmed, physician-scientist, synaptic physiologist interested in affective disorders. Personal, unaffiliated, account.
Why do individuals with late-stage cancer sometimes struggle with motivation and experience profound apathy? In this multi lab effort @KepecsLab @JanowitzTobias and my lab we are tackling this question 👇🏻 😊 science.org/doi/10.1126/sc…
Norepinephrine signals through astrocytes to modulate synapses | Science Congrats @papouinlab and co-authors 🥳 science.org/doi/10.1126/sc…
👇🏻
Please Share! Nominations are open for the Peter Gruss Young Investigator Award! This award celebrates early-career scientists who have made outstanding contributions to the scientific community through collaboration, creativity, and curiosity-driven research. Know someone doing…
This chart made by Peter Gleick shows the proposed cuts to science graphically. This is bad for America. Please ask Congress to save science. #FundingScienceSavesLives
This budget proposes to cut the NIH by nearly half, a 40% reduction. The NIH has been responsible for an extraordinary number of lifesaving cures and has been an economic power engine unitedformedicalresearch.org/nih-in-your-st… Ask Congress to save science. #FundingScienceSavesLives
Prefrontal encoding of an internal model for emotional inference | Nature nature.com/articles/s4158…
Nice!
🎉Thrilled that the lab’s first paper is out today in @Nature! Credit to the amazing @cesca_gst, @HernyMV and @YviJohansson. Thank you to everyone involved in this massive effort! nature.com/articles/s4158…
Cancer muscle wasting-associated apathy is result of tumour-induced inflammation & brain circuitry interaction 📷 Xiaoyue Aelita Zhu & Sarah Starosta et al @KepecsLab @Pignatelli_Lab @JanowitzTobias @WashUMedNeuro in @ScienceMagazine ➡️ bpod.org.uk/archive/2025/5… + @rooph
Very proud to see this beautiful artwork, highlighting @FedeLucantonio's paper, made by our talented former lab member @qwinkledink on the cover of @NeuroCellPress ! 🤩 Aleesha is now launching her career as a digital illustrator aleeshashi.com please, check her work!
Our latest issue is out: cell.com/neuron/current The cover is for the study by Lucantonio et al. on ketamine's anti-anhedonic action. Artist credit: Aleesha Shi. Read the paper here: cell.com/neuron/fulltex… And a preview of this work by Colleen McClung: cell.com/neuron/fulltex…
In a new Science study, researchers describe a neural circuit underlying cachexia-related apathy in a mouse model of cancer. Learn more ⬇️ 📄: scim.ag/42KkEe6 #SciencePerspective: scim.ag/4lA4BqQ
Very nice study 😊
This study identified a common brain circuit centered on the hippocampus's posterior subiculum linked to lesions causing secondary psychosis. ja.ma/4cfRA15 @fredschaper_ @shansiddiqi
Very interesting ☺️
New issue in Am J Psych @APA_Publishing focusing on schizophrenia. We report a decrease in synapse loss in schizophrenia-derived organoids by inhibiting KAT enzymes @KynexisTx psychiatryonline.org/doi/10.1176/ap…
Important study. 😊
A multi-institutional investigation of psilocybin's effects on mouse behavior biorxiv.org/content/10.110… #biorxiv_neursci
Synapses drive local mitochondrial ATP synthesis to fuel plasticity biorxiv.org/content/10.110… #biorxiv_neursci
Cool !
Online now: An integrated microfluidic and fluorescence platform for probing in vivo neuropharmacology dlvr.it/TK4kNv
Beautifully written. Must read 👇 Check out this article: cnn.com/2025/04/09/hea…
Nice !
DELTA: a method for brain-wide measurement of synaptic protein turnover reveals localized plasticity during learning nature.com/articles/s4159…
Cool ! EPSILON: a method for pulse-chase labeling to probe synaptic AMPAR exocytosis during memory formation | Nature Neuroscience nature.com/articles/s4159…
Very important body of work😍 Glutamate gating of AMPA-subtype iGluRs at physiological temperatures | Nature nature.com/articles/s4158…
1/9: Delighted to announce that our faculty cluster hire for the newly established Noel Drury, M.D. Institute for Translational Depression Discoveries at UC Irvine is now live. The submission deadline is April 9, 2025.