Alicia Pickrell

Excited that our work revealing the regulation of PINK1 by ISR pathway, is out now! A new regulatory axis in mitophagy and mitochondrial quality control. science.org/doi/10.1126/sc… #pink1 #mitophagy #isr #hri #neurodegeneration @mrcppu @dundeeuni @miratul_neuro

Modelling POLG mutations in mice unravels a critical role of POLγΒ in regulating phenotypic severity nature.com/articles/s4146…

Specific targeting of brain endothelial cells using enhancer AAV vectors: Neuron cell.com/neuron/fulltex… (pleased to know that AAV8-P3-Alb-mScarlet was effectively used: addgene.org/183461/)

STING deletion protects against amyloid β–induced Alzheimer's disease pathogenesis alz-journals.onlinelibrary.wiley.com/doi/10.1002/al…

Silencing mitochondrial gene expression in living cells | Science science.org/doi/10.1126/sc…. Wonderful that our paper is out now in Science. A big thanks to LD Cruz-Zaragoza and the team, @warscheidlab & @JakobsLab .

The #mitophagy receptors BNIP3 and NIX mediate tight attachment and expansion of the isolation membrane to #mitochondria, say Shun-ichi Yamashita, Ritsuko Arai, Tomotake Kanki, Satoshi Waguri and colleagues hubs.la/Q03mdl7C0 #Autophagy

Here comes our @NatImmunol N&V on a recent @Nature paper by the Chi lab @StJude on #mitochondria in the regulation of #IFN signaling in #cancer. Kudos to Katia Cosentino and Joost Verduijn! @RicercaUnimore @FoxChaseCancer Available at rdcu.be/emD1n

BREAKING: Your brain’s connective tissue isn’t just glue: It’s a switchboard for neuromodulation. We used to think that astrocytes (the beautiful star-shaped glial cells) were the brain’s 'support staff.' But thanks to exciting new work from Guttenplan and colleagues this week in…

Metin Özdemir, Sven Dennerlein and colleagues define a TOM complex interactome, revealing diverse interaction partners that include the new interactors MAPL, ATAD1 and TRABD. journals.biologists.com/jcs/article/13… #JCSMitoSI #Mitochondria

Neuronal activity influences the growth of #myelin sheaths along axons by signalling through metabotropic glutamate receptor 5 (mGluR5) on oligodendrocytes nature.com/articles/s4159…

Shun-ichi Yamashita, Ritsuko Arai, Tomotake Kanki, Satoshi Waguri et al. show that the #mitophagy receptors BNIP3 and NIX are required for tight attachment & expansion of the isolation membrane along the mitochondrial surface hubs.la/Q03mdcwr0 #Autophagy #Mitochondria

Excited to share our latest paper in @ScienceAdvances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵 science.org/doi/10.1126/sc…

ZBP1 senses splicing aberration through Z-RNA to promote cell death dlvr.it/TKWfn0

Scientists have identified extensive interactions between T and B cells in the meninges that promote CNS inflammation in mouse models of Multiple Sclerosis. Read more in @SciImmunology: scim.ag/44c3qaG

Nature research paper: Human de novo mutation rates from a four-generation pedigree reference go.nature.com/3ECWGs2

Mitochondria are social organelles and they don’t discriminate The Mitochondrial Information Processing System (MIPS) collaborates with all other organelles for the greater good of the cell and organism cell.com/action/showPdf…

Active control of mitochondrial network morphology by metabolism-driven redox state | PNAS pnas.org/doi/10.1073/pn…

Cells have a clever way of flagging damaged DNA so it can be fixed. New research shows they use tiny chemical tags—called m6A—to mark trouble spots and call in repair tools. buff.ly/Ttwi5SX

Astrocytic RNA editing regulates the host immune response to alpha-synuclein | Science Advances science.org/doi/10.1126/sc…

Happy to share a recent publication from our lab @CBM_CSIC_UAM describing a novel unconventional autophagic pathway that inhibits ATP secretion during apoptosis by sequestering it into atypical LC3-positive vesicles rdcu.be/ehdHq