RehlingLab

Online Now: Structural basis for promoter recognition and transcription factor binding and release in human mitochondria dlvr.it/TM5SKN

Ein starkes Signal für Wissenschaft und Innovation! Vielen Dank an den Freistaat Bayern, @Markus_Soeder und @MarkusBlume für die Unterstützung beim Ausbau der #Spitzenforschung und der Life-Sciences in Bayern.

Our story about FASTKD5 is now published at @NAR_Open. It was an amazing collaboration with @hauke_hillen and @Antonio41949078 labs. doi.org/10.1093/nar/gk… FASTKD5 processes mitochondrial pre-mRNAs at non-canonical cleavage sites

Interaction with AK2A links AIFM1 to cellular energy metabolism dlvr.it/TLlYRd

Our study on how mitochondrial methylation shapes gene expression is now out. Using long-read RNAseq and cryo-EM, we uncover two methylation-dependent checkpoints in ribosome biogenesis. Read all about it at: rdcu.be/etk12

Online now - Discussing the future of mitochondrial biochemistry dlvr.it/TLWD7C

SMIM20 promotes complex IV biogenesis and Ca2+ signaling in mice heart: Cell Reports cell.com/cell-reports/f…. Great collaboration with @niels_voigt, @CZphenogenomics, D. Katschinski, & H. Urlaub. Thanks to Angela Boshnakovska, Laura Kremer and our lab!

Silencing mitochondrial gene expression in living cells | Science science.org/doi/10.1126/sc…. Wonderful that our paper is out now in Science. A big thanks to LD Cruz-Zaragoza and the team, @warscheidlab & @JakobsLab .

Great collaboration with @hauke_hillen and @RehlingLab. Thank you very much to everyone involved.

If you’re curious about the intricate control of human mitochondrial translation, take a look at our latest review - just out!

Understanding mitochondrial protein import: a revised model of the presequence translocase: Trends in Biochemical Sciences cell.com/trends/biochem…. New review, describing current advances regarding the TIM23 complex. Great work by Naintara Jain together with Agnieszka Chacinska.

In situ architecture of the human prohibitin complex nature.com/articles/s4155…

We recruit leaders on different stages and offer unique atmosphere of a vibrant an open research community. Strenghtening interdyscyplinarity is well seen! Also for: - Scientists with commercialization interests and/or targeted projects !!! - US based scientists !!!

A microscopy-based screen identifies cellular kinases modulating mitochondrial translation: Cell Reports cell.com/cell-reports/f…. a great end of the year. Thanks to our collaborators @RDennerlein_Lab, @RizzoliSilvio @DavidPacheu and Henning Urlaub

Valenti, David, Schuldiner et al. @WeizmannScience created a proteome-wide yeast degron library for rapid in vivo protein depletion. This tool enables dynamic protein function studies with minimal cellular rewiring, advancing beyond prior collections. hubs.la/Q0302VkW0

Wir freuen uns mit @yourUMG und @moser_tmoser über die Bewilligung eines neuen SFB. Ziel ist es, vorhandene Therapien für Patient*innen mit Sinnes- und Bewegungseinschränkungen zu verbessern und neue Behandlungsansätze zu finden. Mehr unter s.gwdg.de/g6snF5 @dfg_public

Welcome on X @RizzoliSilvio! Silvio is the speaker of our SFB!

PhD students—Do this and 90% of your paper problems will disappear. The secret to getting your papers accepted isn't what you think. It's about... 10 rules to structure your papers like you mean business. I wish I knew these when I started my PhD. Here they are:

Super excited to share our latest work on the native in-cell organization of the mitochondrial respiratory chain 🥳 Using cryo-electron tomography🔬, we show how the respiratory complexes (and other complexes) are organized inside native mitochondria!  biorxiv.org/content/10.110…