Mostoslavsky Lab
@MostoslavskyLab
The Mostoslavsky lab at Harvard & Mass General Cancer Center. We study chromatin, cancer, metabolism, DNA repair, PTMs et al. Tweets are from anyone in the lab!
Really excited to share our new study, where we identified ZNF280A, a novel regulator of homologous recombination during DNA repair, linked to the human 22q11.2 distal deletion syndrome. A special shout out to @ThomasLClarke for leading the project! nature.com/articles/s4155…
FOR THE LOVE OF PURINES: We are truly excited to share our latest work @CellPressNews on mapping the routes of purine nucleotide synthesis in vivo-De novo and Salvage Purine Synthesis Pathways Across Tissues and Tumors.cell.com/cell/fulltext/…
We’re happy to share our new study out today @NatureCellBio We show that a chromatin factor, ZNF280A, is required for DNA double strand break repair, linking its absence to clinical features in 22q11.2 distal deletion syndrome. @MostoslavskyLab nature.com/articles/s4155…
Excited to share our new work on how DNAJB1-PRKACA drives cancer cell growth in Fibrolamellar Carcinoma. @CD_AACR Thanks to all our collaborators and funding support. @FibroFoundation @AICF_nyc @DonaBertarelli @ForbeckForums @AlexLemonade
Now online in @CD_AACR: DNAJB1-PRKACA Drives #Fibrolamellar Liver Cancer via Impaired SIK Signaling & CRTC2/p300-mediated Transcriptional Reprogramming - by @IlariaG32, @DoransRing6012, Taranjit Gujral, Nabeel Bardeesy, et al. doi.org/10.1158/2159-8… @fredhutch @MGHCancerCenter
New Research: Subcellular one carbon metabolism in cancer, aging and epigenetics frontiersin.org/articles/10.33… #FrontiersIn #Epigenetics #Epigenomics
Really happy to share our new mini Review on One Carbon Metabolism and chromatin (fantastic job by @Tiz_bernasocchi. Out in @FrontGenetics frontiersin.org/journals/epige…
New in @sciencemagazine! Our study reveals how mutant IDH1 inhibition activates tumor immunity by inducing dsDNA sensing. Read more: science.org/doi/10.1126/sc… #CancerResearch #Cholangiocarcinoma #IDH1 1/n
Thrilled to be a Keynote Speaker at the Center of Excellence in Chromosome Biology (CECB) Symposium in @theNCI. Thanks @WeyemiLab and @LabShalini for the honor!
Massive effort by Christina Ferrer @MostoslavskyLab! I am so happy to see this piece of work finally published!
Online now!! Really thrilled to share our latest work identifying a novel driver of metastasis, Gstt1, @NatureCellBio. A huge effort lead by Christina Ferrer and an incredible team of collaborators!! link.springer.com/article/10.103…
I am thrilled and honored to announce that I have been selected (together with the laboratory of Nabeel Bardeesy) as a 2023 Breakthrough Krantz Award recipient! Thank to our teams and the #KrantzCenter for their support and generosity! massgeneral.org/cancer-center/… #MassGeneral
I am really happy to share that our latest study was published today in Nature Metabolism! We discovered a new way by which cancer cells can adapt to proliferate under glutamine restricted conditions. Amazing work Sam and Tiz!!!! nature.com/articles/s4225…
María Belén Machin, PhD, was awarded the 2023 Pew Latin American Fellows postdoctoral fellowship! @pewtrusts
What a thrill! So proud of @YaaAmoh for being selected as a #GilliamFellows! It is such a unique opportunity, for her as a Fellow and for me as a mentor, to engage, network and be inspired by this community. Can't wait for the amazing science you will do as a Fellow. Congrats!!
🎉Happy Gilliam Day! 🎉We’re excited to announce the 50 new #GilliamFellows and their advisers who are committed to advancing equity and inclusion in science. hhmi.news/3rKsRPv
I’m thrilled to share that I will be joining the Boston University School of Medicine (@BUMedical) as an assistant professor! My lab will officially open on January 1, 2024, in the Department of Pathology and Laboratory Medicine.