Nathaniel David
@NathanielEDavid
drug hunter, baker, biochemistry & Bach
cool result. turns out you need the right sugar coating on your blood vessels as your age to keep them from leaking into your brain.
Excited to share our new study in @Nature! We uncover how the vascular glycocalyx—a carbohydrate-rich coating on blood vessels—plays a crucial role in brain health and aging. A @wysscoray & @CarolynBertozzi labs collaboration. 🍭🧠 #glycotime (1/12) nature.com/articles/s4158…
our educational system is extremely unfun. you're forced in a classroom metabolizing lifespan for 8 hours a day, cramming homework, memorizing lists... we want creative project-based learning. 1:1 tutoring. personalized, self-paced lesson plans. joy and mastery drive discipline!
Magnus Carlsen gives a great explanation of the extraordinary power of what @DavidDeutschOxf has coined the 'fun criterion'... and the perils of its negation.
This is like AlphaFold, but for protein localisation rather than folding It's a deep learning model that predicts a protein's subcellular compartment based on its amino acid sequence alone:
CAR T cells have shown efficacy in blood cancers and autoimmune disease. In my lab’s recent preprint, we developed CAR Tregs to tackle the #1 cause of human mortality - heart disease. biorxiv.org/content/10.110…
cool
In my 40 years of biotech, I was waiting to see this result. Never before have transplanted cells survived normal immune response without immunosuppression. Excited for patients, many whom I know see hope today for a possible cure for many diseases. globenewswire.com/news-release/2…
In my 40 years of biotech, I was waiting to see this result. Never before have transplanted cells survived normal immune response without immunosuppression. Excited for patients, many whom I know see hope today for a possible cure for many diseases. globenewswire.com/news-release/2…
2024's top 10 advances in medicine (🧵) 1. The numerous benefits of GLP1R agonists As well as causing weight loss, GLP1s can prevent complications of obesity (diabetes, liver fibrosis, kidney disease, osteoarthritis), treat heart failure, and even slow down Parkinson's:
This is what the internet was made for
GDF15 positioned as a dynamic biomarker of psychosocial stress accessible in human blood and saliva, pointing towards a shared psychobiological pathway linking mental and mitochondrial energetic stress. biorxiv.org/content/10.110…
have to do it manually now alas
Someone needs to make some kind of extension or forked version of Promethease that can suck in 23andme or any full genome sequence in VCF file format or something else standard & spit out status for all important-to-aging/longevity SNPs. Rhonda Patrick has a tool but it (a) only…
You can check out your foxo3 status using your 23&me raw data.
Genetic variants associated with longevity in long-living Indians @anuacharya2007 nature.com/articles/s4151… More: Unveiling the Secrets of Longevity in India go.nature.com/4eHaY6K
brawhaha. DOSE!!! @Aiims1742 @LifeSciVC @matthewherper
A missed opportunity to name this D.O.S.E. (Department Of Startup Efficiency). 🐕 Good luck to @nes047 and @NathanielEDavid!
A missed opportunity to name this D.O.S.E. (Department Of Startup Efficiency). 🐕 Good luck to @nes047 and @NathanielEDavid!
yay, bruce! @LifeSciVC
"Capital excess… is death" "the best decisions are made when you are under capital constraint” - Ned David. Agree 💯 Former NCI chief and serial biotech entrepreneur raise $70 million to start companies that fail fast statnews.com/2024/11/19/jup… via @statnews
🧬What are protein language models (PLMs) actually learning about biology? Our paper introduces InterPLM - a framework that reveals interpretable features in PLMs using sparse autoencoders, giving us a window into how these models represent protein structure and function. 🧵(1/9)
so then the bartender asks…. the regular? endpts.com/jupiter-bioven…
so 2 guys named Ned walk into a bar . . . statnews.com/2024/11/19/jup…
Molecular dynamics simulations in mixed reality! With @labriataphd and @lucien_krapp we’re scaling our multi-user WebXR platform to enable immersive molecular simulations, fully based on web technologies. Stay tuned, lots of cool stuff coming soon! @threejs #WebXR #Quest3
i’ve always been puzzled as to the mechanism that might explain why glucose drives aspects of aging. This paper shows a totally new way in which glucose exerts biology. Could elevated glucose be driving pathological cell fate decisions?
Our latest out today @Nature! We revisit a century-old theory and show that metabolic gradients work hand-in-hand with genetic&signalling instructions to shape the embryo. Glucose isn't just an energy source, it acts as a major conductor of the body plan🍬 nature.com/articles/s4158…
nytimes.com/2024/10/07/sci… Comb jellies (cute jellyfish that blink like xmas lights) do something bonkers. Cut two of them in half . . . and put the halves of two DIFFERENT jellies together, and they fuse into one creature. two nervous systems become one! Holy shit