The Muir Lab
@MuirLab
The Muir lab investigates the physiochemical basis of protein function in complex systems of biomedical interest.
The final version of our protein transposition manuscript is now published in @ScienceMagazine science.org/doi/10.1126/sc… We’ve added a few new things since our preprint /1
Ever wanted to swap out an entire internal region of a folded protein for functional biochemical studies? Check out our preprint that has been 5 years in the making, in which we establish a protein editing platform via protein transposition, enabling the insertion of functional…
Yesterday, we announced the close of a $135M Series B financing to support clinical development of SB-007 for #StargardtDisease, including the ongoing Phase 1/2 ASTRA and POLARIS studies. Stay tuned as we advance our broader pipeline of genetic medicines. bit.ly/3ZpxYmi
The @SpliceBio platform is based on technology developed in @MuirLab at @Princeton.
Yesterday, we announced the close of a $135M Series B financing to support clinical development of SB-007 for #StargardtDisease, including the ongoing Phase 1/2 ASTRA and POLARIS studies. Stay tuned as we advance our broader pipeline of genetic medicines. bit.ly/3ZpxYmi
Employing engineered split inteins to replace the internal regions of target proteins in a single reaction. science.org/doi/10.1126/sc… #NBThighlight
Congratulations to our trailblazing leader!
Proud to announce that Tom Muir has been awarded the 2025 Bristol Myers Squibb Award in Enzyme Chemistry and Chemical Biology from the ACS Division of Biochemistry and Chemical Biology. Congratulations Tom! Announcement: bit.ly/4dBxNtM
Congratulations to our second years Alan and Chuqi for passing their general exams and officially becoming PhD candidates!
That’s a wrap for our 3rd year seminars, who all did a fantastic job presenting updates on their research progress!
A new protein editing technology from @MuirLab at @PrincetonChem could give scientists a new tool to combat disease in the human body: bit.ly/435Ok4j
"Native nucleosomes know where to go!” Our Condense-seq paper is now published in Nature! 📄 nature.com/articles/s4158… I’m deeply grateful to my PhD advisor @taekjip and our incredible collaborators @MuirLab , @binzmit , Erika Pearce, and Ben Garcia lab!!
Check out our latest review in Accounts of Chemical Research showcasing how integrating chemical biology, biochemistry, and genetics tools can enable deep interrogation of biological pathways involved in bacterial quorum sensing. Congrats @StevenPBodine! pubs.acs.org/doi/full/10.10…
Congratulations @MuirLab on their groundbreaking method for protein editing recently out in @ScienceMagazine and featured in @Nature. Great work Yi, Nick, Xuanjia, Jeremy, Robert, and Tom! Enjoy our story on the details behind the science: bit.ly/44W8MqQ
Sincere thanks to these wonderful young chemists, Kaylee and Caitlin, who’ve given their time to the @PrincetonChem ChemSTEM outreach program, presenting virtual talks to high school chemistry students on #gradstudentlife. Looking forward to more ChemSTEM programs next fall!
Be a part of the Chandler Medal Lecture ft Prof Tom Muir @MuirLab and hosted by Prof Ann McDermott This talk will explore innovations in harnessing inteins for protein engineering, don’t miss this deep dive into synthetic biology! Join this Thursday 3/13 @ 4:30p, Havemeyer 209
Great to have our annual @kadochlab -@MuirLab think tank collaboration meeting, this time up in Boston!
Check out our most recent work published today in JPCC! @MuirLab @ACSPublications pubs.acs.org/doi/10.1021/ac…
PRESS RELEASE: EXCITED to share NEW STUDY from @themazelab! Findings from collaborative effort between @IcahnMountSinai & @MSKCancerCenter could eventually guide dvlpmnt of targeted therapies for conditions involving #CircadianRhythm disruptions. mountsinai.org/about/newsroom…