Kadoch Lab
@kadochlab
The Kadoch Lab at Dana-Farber Cancer Institute, Harvard Medical School, and the Broad Institute — studying chromatin regulation in human disease.
Great to have our annual @kadochlab -@MuirLab think tank collaboration meeting, this time up in Boston!
A happiest time for the @kadochlab at our annual holiday party!!! Let’s go, 2025!! 🎉🎉🎉
Happy Holidays from the @kadochlab !! Wishing all of our colleagues, collaborators, and friends near and far a most happy holiday season and a terrific 2025 New Year!
@kadochlab happy hour on the beautiful @harvardmed quad this evening! So proud of our amazing team!
Congratulations to our @kadochlab graduate student, now officially Dr. Ajinkya Patil @ajinkyapatil00 on his graduation from @VirologyHarvard @harvardmed !! And to past computational biologist and @BBS_Harvard student Dr. John Pulice @JohnPulice !!!
Congratulations, Dr. @ajinkyapatil00 on your official graduation from @harvardmed and an honor to hood you and meet your family!! So many amazing achievements in your PhD! And thrilled to watch past @kadochlab member Dr. @JohnPulice also walk across the stage! Congratulations!!!
Congratulations to @whit_lieberman in our lab who had just been officially awarded an NIH F31 fellowship to support her exciting graduate studies! We are thrilled!! @kadochlab @chemical_phd
Thrilled to watch @Jstlaurent_MD from our @kadochlab and supported by @RsdpScholars present her fantastic new work on mechanistically dissecting and targeting mSWI/SNF #BAF complex remodelers in aggressive endometrial #cancers @AACR #AACR24 #aacr here in San Diego!
Thanks to Arena investor @stevepagliuca, Arena scientist @JKeithJoung, LabCentral's @JFruehauf, Dana-Farber's @CKadoch, Arcadia's @seemaychou, and several others for talking to me about the evolving landscape between academia and industry for this story.
Congrats to @BBS_Harvard graduate student Kevin So and computational biologist Alex Ying from the lab on their collaborative work on SCLC with the @Oser_Lab , now posted as a pre-print on @biorxivpreprint !
Excited to share our latest, a wonderful collaboration with @CKadoch @kadochlab, using positive-selection CRISPR screening to show that Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer biorxiv.org/content/10.110….
As we roll into 2024 in full gear, a picture of our fun and talented group at the end-of-year Kadoch Lab holiday party! #LetsGo #research #Science #CancerResearch #chromatin #generegulation #humandisease
Thank you, @wendywenderski !! @ajinkyapatil00 @CKadoch
Another day, another beautiful mechanistic study on BAF chromatin remodeling from @kadochlab!
New work from @ajinkyapatil00 in the lab out this week in @CellCellPress -- a wonderful collaboration with @DNAmyStrom @brangwynnelab and @PappulabWashU to define the contributions of #disordered #proteins (#IDRs)to #chromatinremodeling!
Now online! A disordered region controls cBAF activity via condensation and partner recruitment dlvr.it/Swwyy7
Huge congratulations to @ajinkyapatil00 from the @kadochlab on this exciting paper published this week in @CellCellPress! Beautiful work with @DNAmyStrom @brangwynnelab @PappulabWashU to dissect the sequence grammar of IDRs and their role in #mSWISNF #BAF #chromatin complexes!
Excited to have the final part of my graduate work from the @Kadochlab @DanaFarber @DanaFarberNews out today in @CellCellPress, where we dissect the (exciting!) role of ARID1A and ARID1B, two of the most mutated mSWI/SNF complex subunits! cell.com/cell/fulltext/…
Chromatin remodelers 🤝 Precision medicine Aided by CUTANA CUT&RUN/Library Prep, Politi and @kadochlab show SWI/SNF inhibition reverses #drugresistance in EGFR-mutant lung cancers - highlighting the potential of epigenetics to advance precision therapies hubs.la/Q01-nfrf0
Congratulations to @DanaFarber's Cigall Kadoch, Ph.D., and Eric S. Fischer, Ph.D., who've ranked among the 2023 @BlavatnikAwards finalists. The award recognizes America's most inventive faculty-ranked scientists and engineers under 42. dana-farber.org/newsroom/news-…
Latest from @kadochlab, co-led by the amazing @claudiagentile_ and @CKadoch! Reversing TKI resistance is bound to be extremely useful in the clinic!
Excited to share that my postdoc work is now published in Cancer Cell! This work, co-led by @fdemiguelsdp and myself, reveals that mSWI/SNF complexes promote TKI resistance in #EGFR-mutant lung cancer. @DanaFarber @kadochlab @DanaFarberNews sciencedirect.com/science/articl… Tweetorial ⬇️
Congratulations to @DanaFarber’s Cigall Kadoch, PhD, and Eric S. Fischer, PhD, finalists for the 2023 Blavatnik National Awards for Young Scientists which honor outstanding scientists and engineers under the age of 42. @blavatnikawards @Nyasciences dana-farber.org/newsroom/news-…